scholarly journals Genetic Association of the Porcine C9 Complement Component with Hemolytic Complement Activity

2015 ◽  
Vol 28 (9) ◽  
pp. 1354-1361 ◽  
Author(s):  
D. V. A. Khoa ◽  
K. Wimmers
Keyword(s):  
Genetic Association ◽  
Complement Component ◽  
Complement Activity ◽  
Hemolytic Complement Activity

Genetic Association Study of Schizophrenia Fisk Locus Complement Component 4 and Age at Onset of Psychosis

2020 ◽  
Vol 87 (9) ◽  
pp. S177-S178
Author(s):  
Jennie Pouget ◽  
Julia Woo ◽  
Cheng Chen ◽  
Natalie Freeman ◽  
Arun K. Tiwari ◽  
...  
Keyword(s):  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Age At Onset ◽  
Complement Component ◽  
Complement Component 4

Genetic association of complement component 2 variants with chronic hepatitis B in a Korean population

2018 ◽  
Vol 38 (9) ◽  
pp. 1576-1582 ◽  
Author(s):  
Suhg Namgoong ◽  
Joong‐Gon Shin ◽  
Hyun Sub Cheong ◽  
Lyoung Hyo Kim ◽  
Ji On Kim ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Genetic Association ◽  
Chronic Hepatitis B ◽  
Complement Component ◽  
Korean Population

Early Decrease in Total Hemolytic Complement Activity (CH100) after Fasting or Intestinal Bypass in the Rat

1986 ◽  
Vol 18 (1) ◽  
pp. 36-40
Author(s):  
M. Montanari ◽  
V. Violi ◽  
M. Muri ◽  
L. Roncoroni ◽  
G. Mora ◽  
...  
Keyword(s):  
Intestinal Bypass ◽  
Complement Activity ◽  
Hemolytic Complement Activity

scholarly journals Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity

2015 ◽  
Vol 194 (7) ◽  
pp. 3305-3316 ◽  
Author(s):  
Georgia Sfyroera ◽  
Daniel Ricklin ◽  
Edimara S. Reis ◽  
Hui Chen ◽  
Emilia L. Wu ◽  
...  
Keyword(s):  
Complement Component ◽  
Loss Of Function ◽  
Complement Activity ◽  
Complement Component C3 ◽  
Insight Into

scholarly journals Study of hemolytic activity and subfactors of complement in smokers intoxication

2019 ◽  
Author(s):  
Rojan Ghanim Al Allaf
Keyword(s):  
Hemolytic Activity ◽  
Normal Values ◽  
Control Group ◽  
Healthy Individuals ◽  
Complement Components ◽  
Complement Activity ◽  
Normal People ◽  
Hemolytic Complement Activity ◽  
Heavy Smokers

Abstract Heavy Smokers appeared to be less resistant to infection, such as bacteria, viruses, and parasites. Many studies have examined the complement components concentrations than compared with normal people and ignored the functional sequencing of complement components, our study included the determination of complement activity by using Sheep red blood cells (SRBCs) as antigen and extracting the hemolytic activity (50%) of complement compounds, and because of difficulty of this method we using statistical analysis program (SPSS 23) and derived the inverse equation which gives the decomposition percentage (1-100%) of complement components by using five serum dilutions only. The total hemolytic complement activity (CH50) and its C3 and C4 fractions were determined in 30 heavy smokers. The results were compared with a control group that contained 30 persons matched in age and sex. Generally, both C3 and C4 concentrations were increased in smoker's individual in compared with the control group. However, when the independent t-test has applied the differences in the C3 and C4 levels in the control group (healthy individuals) and in the smoker group were found to be statistically insignificant but the inverse equation showed a 7% reduction in CH50 in smokers compared with the control group, where 18% reduction was observed. Our current study suggests that the complement components of the heavy smokers suffer from a significant dysfunction in the function, although the concentration of the basic components in the serum is parallel with normal values.

Automated homogeneous liposome-based assay system for total complement activity

1995 ◽  
Vol 41 (4) ◽  
pp. 586-590 ◽  
Author(s):  
S Yamamoto ◽  
K Kubotsu ◽  
M Kida ◽  
K Kondo ◽  
S Matsuura ◽  
...  
Keyword(s):  
Serum Proteins ◽  
M Protein ◽  
Homogeneous Population ◽  
Complement Activity ◽  
Activity Test ◽  
Human Sera ◽  
Total Complement ◽  
Hemolytic Complement Activity ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract We developed an automated homogeneous immunoassay, based on immune lysis of dinitrophenyl (DNP)-labeled liposomes, for measuring total complement activity. Liposome lysis caused by complement activity was detected spectrophotometrically from entrapped glucose-6-phosphate dehydrogenase activity. Complement activity in human sera was quantified by comparison with a calibration curve. For ease of application to fully automated routine clinical analyzers, we adopted a two-reagent system, one reagent containing a homogeneous population of small DNP-labeled liposomes and one containing antibody/substrate. This system required calibration only once a week. Within-run and between-run CVs were 0.4-1.3% (n = 10) and 1.8-4.7% (n = 10), respectively. Serum results were linear upon dilution (with saline) over a twofold range. Bilirubin, hemoglobin, Intrafat, and serum proteins such as rheumatoid factor, M protein, IgG, and IgA did not affect the assay results. The results (y) correlated well with those from a hemolytic complement activity test (x): y = 1.05x - 1.14, r = 0.92, on 66 samples in the range < 10- > 50 kU/L. This method should therefore be of great use for the determination of complement activity.

scholarly journals INHIBITION OF 125I-C3 UPTAKE ANH HEMOLYTIC COMPLEMENT ACTIVITY BY IV IgG

1984 ◽  
Vol 18 ◽  
pp. 253A-253A
Author(s):  
Melvin Berger ◽  
Carmen Y Brown ◽  
Pnina Rosenkranz
Keyword(s):  
Complement Activity ◽  
Hemolytic Complement Activity
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