scholarly journals Paternal inheritance of mitochondrial DNA in Chlamydomonas reinhardtii and dynamic morphological changes in mitochondria, mitochondrial nucleoids, and the cell nucleus during its life cycle

2016 ◽  
Vol 28 (1) ◽  
pp. 35-42
Author(s):  
Soichi Nakamura
Keyword(s):  
Mitochondrial Dna ◽  
Life Cycle ◽  
Chlamydomonas Reinhardtii ◽  
Cell Nucleus ◽  
Morphological Changes ◽  
Paternal Inheritance ◽  
Mitochondrial Nucleoids

scholarly journals Experimental evolution of an alternating uni- and multicellular life cycle in Chlamydomonas reinhardtii

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
William C. Ratcliff ◽  
Matthew D. Herron ◽  
Kathryn Howell ◽  
Jennifer T. Pentz ◽  
Frank Rosenzweig ◽  
...  
Keyword(s):  
Life Cycle ◽  
Chlamydomonas Reinhardtii ◽  
Experimental Evolution

scholarly journals The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization

2007 ◽  
Vol 176 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Jiuya He ◽  
Chih-Chieh Mao ◽  
Aurelio Reyes ◽  
Hiroshi Sembongi ◽  
Miriam Di Re ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Uncharacterized Protein ◽  
Supercoiled Dna ◽  
Recombinant Fragment ◽  
Loop Region ◽  
Mitochondrial Nucleoids ◽  
Marked Preference ◽  
D Loop ◽  
Aaa Protein

Many copies of mammalian mitochondrial DNA contain a short triple-stranded region, or displacement loop (D-loop), in the major noncoding region. In the 35 years since their discovery, no function has been assigned to mitochondrial D-loops. We purified mitochondrial nucleoprotein complexes from rat liver and identified a previously uncharacterized protein, ATAD3p. Localization studies suggested that human ATAD3 is a component of many, but not all, mitochondrial nucleoids. Gene silencing of ATAD3 by RNA interference altered the structure of mitochondrial nucleoids and led to the dissociation of mitochondrial DNA fragments held together by protein, specifically, ones containing the D-loop region. In vitro, a recombinant fragment of ATAD3p bound to supercoiled DNA molecules that contained a synthetic D-loop, with a marked preference over partially relaxed molecules with a D-loop or supercoiled DNA circles. These results suggest that mitochondrial D-loops serve to recruit ATAD3p for the purpose of forming or segregating mitochondrial nucleoids.

Mitochondrial DNA of Chlamydomonas reinhardtii: the structure of the ends of the linear 15.8-kb genome suggests mechanisms for DNA replication

1993 ◽  
Vol 24 (3) ◽  
pp. 241-247 ◽  
Author(s):  
Carola Vahrenholz ◽  
Gudula Riemen ◽  
Elke Pratje ◽  
Bernard Dujon ◽  
Georg Michaelis
Keyword(s):  
Mitochondrial Dna ◽  
Dna Replication ◽  
Chlamydomonas Reinhardtii

scholarly journals Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation

2008 ◽  
Vol 181 (7) ◽  
pp. 1117-1128 ◽  
Author(s):  
Robert W. Gilkerson ◽  
Eric A. Schon ◽  
Evelyn Hernandez ◽  
Mercy M. Davidson
Keyword(s):  
Mitochondrial Dna ◽  
Protein Synthesis ◽  
Molecular Mechanism ◽  
Cell Lines ◽  
Mitochondrial Protein ◽  
Functional Complementation ◽  
Mitochondrial Protein Synthesis ◽  
Protein Assemblies ◽  
Mtdna Mutations ◽  
Mitochondrial Nucleoids

Mitochondrial DNA (mtDNA) is packaged into DNA-protein assemblies called nucleoids, but the mode of mtDNA propagation via the nucleoid remains controversial. Two mechanisms have been proposed: nucleoids may consistently maintain their mtDNA content faithfully, or nucleoids may exchange mtDNAs dynamically. To test these models directly, two cell lines were fused, each homoplasmic for a partially deleted mtDNA in which the deletions were nonoverlapping and each deficient in mitochondrial protein synthesis, thus allowing the first unequivocal visualization of two mtDNAs at the nucleoid level. The two mtDNAs transcomplemented to restore mitochondrial protein synthesis but were consistently maintained in discrete nucleoids that did not intermix stably. These results indicate that mitochondrial nucleoids tightly regulate their genetic content rather than freely exchanging mtDNAs. This genetic autonomy provides a molecular mechanism to explain patterns of mitochondrial genetic inheritance, in addition to facilitating therapeutic methods to eliminate deleterious mtDNA mutations.

Morphological changes during the life cycle ofAureobasidium pullulans (de Bary) Arnaud

1980 ◽  
Vol 25 (1) ◽  
pp. 56-67 ◽  
Author(s):  
A. Kocková-Kratochvílová ◽  
M. Černáková ◽  
E. Sláviková
Keyword(s):  
Life Cycle ◽  
Morphological Changes

scholarly journals Further evidence for paternal inheritance of mitochondrial DNA in the sheep (Ovis aries)

Heredity ◽  
2004 ◽  
Vol 93 (4) ◽  
pp. 399-403 ◽  
Author(s):  
X Zhao ◽  
N Li ◽  
W Guo ◽  
X Hu ◽  
Z Liu ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Ovis Aries ◽  
Paternal Inheritance

scholarly journals Life cycle control of Chlamydomonas reinhardtii

2003 ◽  
Vol 4 ◽  
pp. spotlight-20030423-01
Author(s):  
C L Bishop
Keyword(s):  
Life Cycle ◽  
Chlamydomonas Reinhardtii
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