scholarly journals Cognitive Functions in Combat Posttraumatic Stress Disorder

2020 ◽  
Vol 44 (4) ◽  
pp. 199-207
Author(s):  
Ana Havelka Meštrović ◽  
Marina Domijan ◽  
Vlatko Mičković ◽  
Zoran Lončar

Posttraumatic stress disorder (PTSD) is associated with changes in cognitive functions. The aim of the study was to investigate differences in cognitive abilities between PTSD patients and healthy controls. As PTSD is often accompanied by comorbidity, the PTSD patients with comorbid diagnoses were also included in our study. The study participants included 254 Croatian combat veterans (60 PTSD and 194 PTSD plus comorbidity) and control group of 125 healthy Croatian military and civilian pilots. The diagnosis of PTSD was made by clinical scale for PTSD assessment (CAPS), while cognitive abilities were measured by Wechsler intelligence scale (WAIS-III-R) and Rey test (ROCFT). The study results have confirmed that there is a significant difference in cognitive functions between the PTSD patients and healthy controls regarding age and education. The PTSD patients (PTSD only and PTSD with comorbidity) have shown lower general intellectual abilities, reduced capacity of working, numerical and visual memory, and decreased executive functions when compared to healthy controls. These results are an additional contribution to a better understanding and determination of changes in cognitive functions that occur in combat PTSD as a result of traumatic stress.

2017 ◽  
Vol 41 (S1) ◽  
pp. S359-S360 ◽  
Author(s):  
D. Sabic ◽  
A. Sabic

The aim of this study was to analyse frequency of embitterment in war veterans with Posttraumatic stress disorder (PTSD) as well as the potential impact of embitterment on the development of chronic PTSD.Patients and methodsIt was analyzed 174 subjects (from Health Center Zivinice/mental health center) through a survey conducted in the period from March 2015 to June 2016, of which 87 war veterans with PTSD and control subjects 87 war veterans without PTSD. The primary outcome measure was the post-traumatic embitterment disorder self-rating scale (PTED Scale) who contains 19 items designed to assess features of embitterment reactions to negative life events. Secondary efficacy measures included the clinician-administered PTSD scale–V (CAPS), the PTSD checklist (PCL), the combat exposure scale (CES), the Hamilton depression rating scale (HAM-D), the Hamilton anxiety rating scale (HAM-A) and the World health organization quality of life scale (WHOQOL-Bref). All subjects were male. The average age of patients in the group war veterans with PTSD was 52.78 ± 5.99. In the control group, average age was 51.42 ± 5.98. Statistical data were analyzed in SPSS statistical program.ResultsComparing the results, t-tests revealed significant difference between group veterans with PTSD and control group (t = −21,21, P < 0.0001). War veterans group with PTSD (X = 51.41, SD = 8,91), control group (X = 14.39, SD = 13.61).ConclusionEmbitterment is frequent in war veterans with PTSD.Disclosure of interestThe authors have not supplied their declaration of competing interest.


2018 ◽  
Vol 53 (1) ◽  
pp. 37-47 ◽  
Author(s):  
Caroline J Bell ◽  
Chris M Frampton ◽  
Helen C Colhoun ◽  
Katie M Douglas ◽  
Virginia VW McIntosh ◽  
...  

Objectives: The primary aim of this study was to investigate neuropsychological function in patients with earthquake-related posttraumatic stress disorder, compared with earthquake-exposed but resilient controls. We hypothesised that individuals with posttraumatic stress disorder would have poorer neuropsychological performance on tests of verbal and visuospatial learning and memory compared with the earthquake-exposed control group. The availability of groups of healthy patients from previous studies who had been tested on similar neuropsychological tasks prior to the earthquakes allowed a further non-exposed comparison. Method: In all, 28 individuals with posttraumatic stress disorder and 89 earthquake-exposed controls completed tests of verbal and visuospatial learning and memory and psychomotor speed. Further comparisons were made with non-exposed controls who had been tested before the earthquakes. Results: No significant difference in performance on tests of verbal or visuospatial memory was found between the earthquake-exposed groups (with and without posttraumatic stress disorder), but the posttraumatic stress disorder group was significantly slowed on tests of psychomotor speed. Supplementary comparison with historical, non-exposed control groups showed that both earthquake-exposed groups had poorer performance on a test of visuospatial learning. Conclusion: The key finding from this study is that there were no differences in verbal or visuospatial learning and memory in individuals with posttraumatic stress disorder compared with similarly earthquake-exposed controls. Compared with non-exposed controls, both earthquake-exposed groups had poorer performance on a test of visuospatial (but not verbal) learning and memory. This offers preliminary evidence suggesting that it is earthquake (trauma) exposure itself, rather than the presence of posttraumatic stress disorder that affects aspects of neuropsychological functioning. If replicated, this may have important implications for how information is communicated in a post-disaster context.


QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A A Ashour ◽  
A M A Nassef ◽  
E M Awad ◽  
A M Hazzou ◽  
M A Nada ◽  
...  

Abstract Background Epilepsy is a serious common neurological disorder that can affect any age. Cognitive functions are highly prevalent in patients with epilepsy and is more likely to occur in patients with idiopathic generalized epilepsy (IGE). Associations were found between cognitive functions and brain volume loss in patients with epilepsy. Objective This work was carried out to assess the volumetric changes in brain of epileptic patients to use it as a biomarker for cognitive dysfunction in adult and adolescent patients with epilepsy. Patients and Methods A case control study was conducted to include 61 patients, 20 of which diagnosed with idiopathic generalized epilepsy (IGE), 21 with temporal lobe epilepsy (TLE) and 20 with frontal lobe epilepsy (FLE) who were selected from the epilepsy outpatient clinic in Ain Shams university hospitals along with 23 age and sex matched healthy controls. Both cases and control groups were subjected to Magnetic resonance imaging MRI brain volumetry and detailed cognitive testing. An informed consent was taken from each adult patient, guardian of adolescent patient and healthy control. Results Statistically significant difference in comprehension subcategory of the Wechsler adult intelligence scale (WAIS) between patients with IGE and healthy controls denoting poorer social judgment in the IGE group. The IGE group also showed poorer performance in digit symbol subcategory of the same test denoting worse psychomotor speed and sustained attention. Also, significant difference in similarities subcategory was found between TLE group and control group denoting poorer abstract thinking among the TLE group. The IGE and TLE groups also showed lower attention and concentration than control group in the mental control subcategory of the Wechsler memory scale (WMS) yet failed to show superiority over each other. No statistically significant difference was found on comparing the whole brain volume between cases and control groups. A statistically significant direct relationship was found between the arithmetic subcategory of WAIS and the whole brain volume of the patients among the patients of the FLE group. Conclusion Patients with IGE had worse psychomotor speed, sustained attention and concentration than healthy controls in addition to poorer social judgment. Also, patients with TLE showed lower attention and concentration together with poorer abstract thinking despite normal IQ. The study also concluded that increased whole brain volume in patients with frontal lobe epilepsy is associated with better mathematical problem solving.


2019 ◽  
Vol 50 (6) ◽  
pp. 956-963 ◽  
Author(s):  
Georgina Clifford ◽  
Caitlin Hitchcock ◽  
Tim Dalgleish

AbstractBackgroundThis study examined the structure of the self-concept in a sample of sexual trauma survivors with posttraumatic stress disorder (PTSD) compared to healthy controls using a self-descriptive card-sorting task. We explored whether individuals with PTSD possess a highly affectively-compartmentalized self-structure, whereby positive and negative self-attributes are sectioned off into separate components of self-concept (e.g. self as an employee, lover, mother). We also examined redundancy (i.e. overlap) of positive and negative self-attributes across the different components of self-concept.MethodParticipants generated a set of self-aspects that reflected their own life (e.g. ‘self at work’). They were then asked to describe their self-aspects using list of positive or negative attributes.ResultsResults revealed that, relative to the control group, the PTSD group used a greater proportion of negative attributes and had a more compartmentalized self-structure. However, there were no significant differences between the PTSD and control groups in positive or negative redundancy. Sensitivity analyses demonstrated that the key findings were not accounted for by comorbid diagnosis of depression.ConclusionFindings indicated that the self-structure is organized differently in those with PTSD, relative to those with depression or good mental health.


2017 ◽  
Vol 63 (1) ◽  
pp. 37-43 ◽  
Author(s):  
John C. Markowitz ◽  
Tse-Hwei Choo ◽  
Yuval Neria

Objective: The Psychotherapies for Chronic PTSD randomised trial found that three 14-week psychotherapies acutely benefitted patients with chronic posttraumatic stress disorder (PTSD). Previous research has reported sustained follow-up benefits for prolonged exposure (PE) and relaxation therapy (RT), but few comparable data exist for interpersonal psychotherapy (IPT). We describe 3-month follow-up for acute responders to all 3 treatments. Method: Acute responders, defined a priori as ≥30% improved from baseline, were reevaluated after 3-month no-treatment follow-up by independent evaluators using the Clinician-Administered PTSD Scale (CAPS). Results: Fifty of 110 initial study entrants met acute responder status at week 14. Forty-three (86%) responders entered follow-up: 23 remitters (CAPS ≤20) and 20 responders. At week 26, 27 had achieved remission status, 10 remained responders, and 6 had relapsed. Of week 14 remitters, 8 of 9 PE, all 8 IPT, and 4 of 6 RT patients remained remitted. Relapse rates were 7% (1/9) for PE, 10% (2/20) for IPT, and 33% (3/9) for RT. At week 26, PE showed greater improvement on CAPS than RT ( P = 0.048) and a trend for superiority over IPT ( P = 0.098), with no significant difference between IPT and RT. Depressive symptoms remained low during follow-up. Conclusions: These are the first systematic data on follow-up responder status and persistence of acute treatment benefits in patients receiving individual IPT for chronic PTSD. Patients generally maintained gains across treatments, fluctuating most in RT. Study limitations include small sample size and brief follow-up interval. PTSD research should employ response and remission criteria.


2011 ◽  
Vol 26 (8) ◽  
pp. 525-531 ◽  
Author(s):  
M.C.W. Kroes ◽  
M.G. Whalley ◽  
M.D. Rugg ◽  
C.R. Brewin

AbstractObjectivePosttraumatic stress disorder (PTSD) is reliably associated with reduced brain volume relative to healthy controls, in areas similar to those found in depression. We investigated whether in a PTSD sample brain volumes in these areas were related to reporting specific symptoms of PTSD or to overall symptom severity.MethodStructural MRI scans were obtained from 28 participants diagnosed with PTSD according to DSM-IV-TR. Participants reported the extent of individual PTSD symptoms using the Posttraumatic Diagnostic Scale. Voxel-based morphometry applying the Dartel algorithm implemented within SPM5 was used to identify volumetric changes, related to PTSD total, symptom cluster, and individual symptom scores.ResultsBrain volume was unrelated to overall PTSD severity, but greater reexperiencing scores predicted reduced volumes in the middle temporal and inferior occipital cortices. Increased reports of flashbacks predicted reduced volume in the insula/parietal operculum and in the inferior temporal gyrus.ConclusionThe data illustrate the value of analyses at the symptom level within a patient population to supplement group comparisons of patients and healthy controls. Areas identified were consistent with a neurobiological account of flashbacks implicating specific abnormalities in the ventral visual stream.


2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Tomás Eduardo Ceremuga ◽  
Stephanie Martinson ◽  
Jason Washington ◽  
Robert Revels ◽  
Jessica Wojcicki ◽  
...  

Posttraumatic stress disorder (PTSD) is characterized by the occurrence of a traumatic event that is beyond the normal range of human experience. The future of PTSD treatment may specifically target the molecular mechanisms of PTSD. In the US, approximately 20% of adults report taking herbal products to treat medical illnesses. L-theanine is the amino acid in green tea primarily responsible for relaxation effects. No studies have evaluated the potential therapeutic properties of herbal medications on gene expression in PTSD. We evaluated gene expression in PTSD-induced changes in the amygdala and hippocampus of Sprague-Dawley rats. The rats were assigned to PTSD-stressed and nonstressed groups that received either saline, midazolam, L-theanine, or L-theanine + midazolam. Amygdala and hippocampus tissue samples were analyzed for changes in gene expression. One-way ANOVA was used to detect significant difference between groups in the amygdala and hippocampus. Of 88 genes examined, 17 had a large effect size greater than 0.138. Of these, 3 genes in the hippocampus and 5 genes in the amygdala were considered significant (P<0.05) between the groups. RT-PCR analysis revealed significant changes between groups in several genes implicated in a variety of disorders ranging from PTSD, anxiety, mood disorders, and substance dependence.


Psichologija ◽  
2003 ◽  
Vol 27 ◽  
pp. 43-52 ◽  
Author(s):  
Evaldas Kazlauskas ◽  
Danutė Gailienė

Straipsnyje analizuojami ilgalaikio traumavimo, kurį patyrė išgyvenusieji politines represijas, psichologiniai efektai. 50 buvusių politinių kalinių, kurie buvo ištremti į Sibiro lagerius, lyginami su panašaus amžiaus kontroline grupe. Nors po traumavimo jau praėjo daugiau kaip 40 metų, nustatyti potrauminio streso sutrikimui būdingi požymiai, kurie parodė, kad ypač sunkaus ir ilgalaikio traumavimo klinikiniai psichologiniai padariniai išlieka ilgai. COMPLEXITY OF LONG-TERM PSYCHOLOGICAL EFFECTS OF POLITICAL REPRESSIONS IN LITHUANIAEvaldas Kazlauskas, Danutė Gailienė SummaryOBJECTIVE: This study examined long-term consequences of political repressions during the Soviet regime in Lithuania. Between 1940 and 1958 more than 300,000 Lithuanians were arrested and deported to Siberia (Anušauskas, 1996). Conditions of imprisonment in Gulag camps were extremely hard and mortality rate from exhaustion and disease was high. Victims who managed to return back to Lithuania suffered from persistent persecutions. Traumatic experiences of former political prisoners were neglected for decades; they had to keep in secret the fact of the imprisonment. Less than 5,000 survivors of political imprisonment still live in Lithuania. Since the introduction of posttraumatic stress disorder in DSM-III (1980) trauma effects have been studied mostly in terms of posttraumatic stress disorder (PTSD). But clinicians and trauma researchers acknowledge controversies in modern understanding of PTSD (Yahuda, MacFarlane, 1995). Severe impairments in personality of victims have been reported by clinicians working with survivors of holocaust, sexual abuse, and victims of torture, but these changes in personality are not accepted in current understanding of PTSD. The concept of PTSD receives more and more critics due to limitations in describing psychological effects after long term traumatic experiences that may lasts for years. Complex posttraumatic stress disorder has been introduced (Herman, 1992) in result of these discussions to describe variety of effects of long term trauma, and acceptance of this concept is growing in the field. There are only few studies on psychological effects of political repressions in former Soviet Union territory. This is the first study of psychological effects of political imprisonment in Lithuania. The goal of present study was to examine traumatic experiences and psychological effects among non-clinical sample of former Lithuanian political prisoners. METHOD: The group of former political prisoners (N=50), with a history of deportation to Gulag camps, was compared with an age and sex matched control group (N=50). Former political prisoners were imprisoned for 6.9 years on average. 43.1 years have passed since their return to Lithuania at a time of research. Semi-structured interviews were used to measure experiences during and after imprisonment. Posttraumatic effects were measured using Lithuanian versions of self-rating scales: Harvard Trauma Questionnaire (Mollica et al., 1992), Impact of Event Scale - Revised (Weiss, Marmar, 1996), Trauma Symptom Checklist (Briere, Runtz, 1989). CONCLUSIONS: Results suggest that traumatic experiences dealing with political imprisonment and exile have long-term complex posttraumatic effects on Lithuanian former political prisoners. Concept of complex posttraumatic disorder is partly supported by results of this study. Limitations of the study due to retrospective nature of the study, elderly age of participants and control group selection are discussed. Further research is required to assess the impact of political oppression during Soviet regime on population of former Soviet Republics.


2020 ◽  
Author(s):  
Ken Fowler ◽  
Nyissa Walsh ◽  
David Morgan

Abstract Background: Individuals with Posttraumatic Stress Disorder (PTSD) experience significant levels of psychological distress which is often moderated by social support. PTSD prevalence and symptomology gender differences tend to exist, and this may have important implications for the potential differential impact of social support. Objectives: The primary objectives of this study were to explore levels of psychological distress and social support in a sample of 364 Canadian adults reporting a PTSD diagnosis by a health professional, and to examine the link between specific social support types and psychological distress overall, and for males and females separately. Methods: Using a cross-sectional, national data file, 117 male and 247 female Canadian adults aged 20-64 reporting PTSD were profiled using the Social Provisions Scale – Short Form (SPS-SF), and the Kessler Psychological Distress Scale (K10), and compared to a sex, age and frequency matched control group without a PTSD diagnosis. Social support subtype scores were subsequently regressed onto psychological distress.Results: The PTSD sample had psychological distress scores that were more than double that of the matched control group, and were significantly lower in overall social support, and on each subscale. A diagnosis of PTSD was found to moderate the effect of social support on psychological distress, and while higher social integration and income predicted lower distress overall, higher reliable alliance scores, personal income, and lower age predicted lower distress for men, and higher social integration but lower guidance scores predicted lower distress for women.Conclusions: Social support subtypes were differentially associated with psychological distress experienced by those with PTSD depending on gender, and this may have important implications for clinical practice.


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