scholarly journals On-the-Road Driving Performance the Morning after Bedtime Use of Suvorexant 20 and 40 mg: A Study in Non-Elderly Healthy Volunteers

SLEEP ◽  
2015 ◽  
Vol 38 (11) ◽  
pp. 1803-1813 ◽  
Author(s):  
Annemiek Vermeeren ◽  
Hong Sun ◽  
Eric F.P.M. Vuurman ◽  
Stefan Jongen ◽  
Cees J. Van Leeuwen ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Driving Performance ◽  
The Road ◽  
On The Road

scholarly journals On-the-road driving performance the morning after bedtime administration of lemborexant in healthy adult and elderly volunteers

SLEEP ◽  
2018 ◽  
Vol 42 (4) ◽  
Author(s):  
Annemiek Vermeeren ◽  
Stefan Jongen ◽  
Patricia Murphy ◽  
Margaret Moline ◽  
Gleb Filippov ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Lateral Position ◽  
Driving Performance ◽  
Symmetry Analysis ◽  
Double Blind ◽  
Clinical Trial Registration ◽  
Previous Night ◽  
The Road ◽  
On The Road ◽  
Mean Differences

Abstract Study Objectives To assess potential effects of lemborexant on next-morning driving performance in adult and elderly healthy volunteers. Methods Randomized, double-blind, double-dummy, placebo and active-controlled, four period incomplete crossover study in 48 healthy volunteers (22 females), 23–78 years old. Participants were treated at bedtime for eight consecutive nights with two of three dose levels of lemborexant (2.5, 5, or 10 mg), zopiclone 7.5 mg (on the first and last night with placebo on intervening nights), or placebo. Driving performance was assessed in the morning on days 2 and 9 using a standardized highway driving test in normal traffic, measuring standard deviation of lateral position (SDLP). Drug–placebo differences in SDLP >2.4 cm were considered to reflect clinically meaningful driving impairment. Results Mean drug–placebo differences in SDLP following lemborexant 2.5, 5, and 10 mg on days 2 and 9 were 0.74 cm or less. The upper bound of the 95% confidence intervals (CIs) for lemborexant treatment groups were all below 2.4 cm and the 95% CIs included zero, indicating that the effects were neither clinically meaningful nor statistically significant. Symmetry analysis further supported the lack of clinically meaningful impairment with lemborexant. Conclusions When assessed starting ~9 h after lemborexant administration at bedtime the previous night, there was no statistically significant or clinically meaningful effect on driving performance in healthy adults and elderly, as assessed by either mean differences in SDLP relative to placebo or symmetry analysis. In this study, lemborexant at doses up to 10 mg was well-tolerated. Clinical Trial Registration clinicaltrials.gov, NCT02583451. https://clinicaltrials.gov/ct2/show/NCT02583451.

scholarly journals Performance on the Road: Examining the Critical Role of Training Effectiveness Amongst the Blue-Collar Employees in Bahrain

2018 ◽  
Vol 8 (9) ◽  
pp. 342-351
Author(s):  
Umair Ahmed ◽  
Soleman Mozammel ◽  
Habib Ahmed
Keyword(s):  
Structural Equation ◽  
Training Programs ◽  
Employee Performance ◽  
Critical Role ◽  
Driving Performance ◽  
Training Effectiveness ◽  
Blue Collar ◽  
Equation Modeling ◽  
The Road ◽  
On The Road

The present study attempted to investigate the role or training effectiveness on the employee performance of blue-collar employees working in Bahrain Transportation sector. Therein, the study examined the effectiveness of five different training programs offered to large vehicle drivers serving in the transportation industry. A total of 135 bus drivers from Alsadiq transport company Bahrain were sampled for the study to outline the effectiveness of three major training programs that they were offered including Customer Handling & Passenger Safety, Health & Hygiene and Guide to traffic laws and driving in Bahrain on their driving performance. Structural equation modeling using smart PLS was used for the present study for data analysis and interpretation. The study found a significant relationship impact of two programs on their driving performance of the respondents. The study forwards theoretical and practical implications and scope for further studies.

scholarly journals Erratum to: On-the-road driving performance the morning after bedtime administration of lemborexant in healthy adult and elderly volunteers

SLEEP ◽  
2020 ◽  
Vol 43 (7) ◽  
Author(s):  
Annemiek Vermeeren ◽  
Stefan Jongen ◽  
Patricia Murphy ◽  
Margaret Moline ◽  
Gleb Filippov ◽  
...  
Keyword(s):  
Healthy Adult ◽  
Driving Performance ◽  
The Road ◽  
On The Road

scholarly journals On-the-road driving performance and driving-related skills in older untreated insomnia patients and chronic users of hypnotics

2014 ◽  
Author(s):  
T. R. M. Leufkens ◽  
J. G. Ramaekers ◽  
A. W. de Weerd ◽  
W. J. Riedel ◽  
A. Vermeeren
Keyword(s):  
Driving Performance ◽  
The Road ◽  
On The Road

scholarly journals A psychological predictor of elders' driving performance: social-comparisons on the road

2013 ◽  
Vol 43 (3) ◽  
pp. 556-561 ◽  
Author(s):  
Becca R. Levy ◽  
Reuben Ng ◽  
Lindsey M. Myers ◽  
Richard A. Marottoli
Keyword(s):  
Social Comparisons ◽  
Driving Performance ◽  
The Road ◽  
On The Road ◽  
Psychological Predictor

scholarly journals Comparing objective wakefulness and vigilance tests to on‐the‐road driving performance in narcolepsy and idiopathic hypersomnia

2021 ◽  
Author(s):  
Denise Bijlenga ◽  
Bram Urbanus ◽  
Nick N. J. J. M. van der Sluiszen ◽  
Sebastiaan Overeem ◽  
Jan G. Ramaekers ◽  
...  
Keyword(s):  
Driving Performance ◽  
The Road ◽  
Idiopathic Hypersomnia ◽  
On The Road

Help on the road: Effects of vehicle manual consultation in driving performance across modalities

2015 ◽  
Vol 73 ◽  
pp. 19-29 ◽  
Author(s):  
Ignacio Alvarez ◽  
Hanan Alnizami ◽  
Jerone Dunbar ◽  
France Jackson ◽  
Juan E. Gilbert
Keyword(s):  
Driving Performance ◽  
The Road ◽  
Road Effects ◽  
On The Road

Medicinal Δ9-tetrahydrocannabinol (dronabinol) impairs on-the-road driving performance of occasional and heavy cannabis users but is not detected in Standard Field Sobriety Tests

Addiction ◽  
2012 ◽  
Vol 107 (10) ◽  
pp. 1837-1844 ◽  
Author(s):  
Wendy M. Bosker ◽  
Kim P. C. Kuypers ◽  
Eef L. Theunissen ◽  
Anke Surinx ◽  
Roos J. Blankespoor ◽  
...  
Keyword(s):  
Driving Performance ◽  
The Road ◽  
Standard Field ◽  
On The Road

Effects of Right Lower Limb Orthopedic Immobilization on Braking Function: An On-The-Road Experimental Study With Healthy Volunteers

2015 ◽  
Vol 54 (4) ◽  
pp. 554-558 ◽  
Author(s):  
Jean-Christophe Murray ◽  
Marc-André Tremblay ◽  
Hélène Corriveau ◽  
Mathieu Hamel ◽  
François Cabana
Keyword(s):  
Experimental Study ◽  
Healthy Volunteers ◽  
Lower Limb ◽  
The Road ◽  
On The Road

scholarly journals On-the-road driving performance of patients with central disorders of hypersomnolence

2021 ◽  
Vol 22 (2) ◽  
pp. 120-126
Author(s):  
N. N. J. J. M. van der Sluiszen ◽  
B. Urbanus ◽  
G. J. Lammers ◽  
S. Overeem ◽  
J. G. Ramaekers ◽  
...  
Keyword(s):  
Driving Performance ◽  
The Road ◽  
On The Road
Sign in / Sign up

Export Citation Format

Share Document