scholarly journals The Childhood Adenotonsillectomy Trial (CHAT): Rationale, Design, and Challenges of a Randomized Controlled Trial Evaluating a Standard Surgical Procedure in a Pediatric Population

SLEEP ◽  
2011 ◽  
Vol 34 (11) ◽  
pp. 1509-1517 ◽  
Author(s):  
Susan Redline ◽  
Raouf Amin ◽  
Dean Beebe ◽  
Ronald D. Chervin ◽  
Susan L. Garetz ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Surgical Procedure ◽  
Pediatric Population ◽  
Controlled Trial ◽  
Randomized Controlled

One‐ versus two‐stage crown lengthening surgical procedure for aesthetic restorative purposes: A randomized controlled trial

2020 ◽  
Vol 47 (12) ◽  
pp. 1511-1521
Author(s):  
Oscar González‐Martín ◽  
Georgina Carbajo ◽  
Marta Rodrigo ◽  
Eduardo Montero ◽  
Mariano Sanz
Keyword(s):  
Randomized Controlled Trial ◽  
Surgical Procedure ◽  
Controlled Trial ◽  
Two Stage ◽  
Randomized Controlled ◽  
Crown Lengthening

A randomized controlled trial of laparoscopic extraperitoneal hernia repair as a day surgical procedure

1996 ◽  
Vol 10 (5) ◽  
pp. 495-500 ◽  
Author(s):  
J. R. Bessell ◽  
P. Baxter ◽  
P. Riddell ◽  
S. Watkin ◽  
G. J. Maddern
Keyword(s):  
Randomized Controlled Trial ◽  
Hernia Repair ◽  
Surgical Procedure ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Octreotide Safety and Efficacy in Pediatric Non-variceal Upper Gastrointestinal Bleeding, A Randomized Controlled Trial

2020 ◽  
Author(s):  
Bahador Mirrahimi ◽  
Pejman Rohani ◽  
Omid Moradi ◽  
Azin Hemmati
Keyword(s):  
Clinical Trial ◽  
Randomized Controlled Trial ◽  
Pediatric Population ◽  
Controlled Trial ◽  
Control Group ◽  
Somatostatin Analogue ◽  
Gi Bleeding ◽  
Upper Gi Bleeding ◽  
Upper Gi ◽  
Randomized Controlled

Abstract Background: Octreotide as somatostatin analogue decrease the production of gastrointestinal (GI) peptides. Its consumption in pediatric population has been limited to control of bleeding episodes with variceal origin. In this randomized controlled trial, we aim to assess octreotide as an add-on therapy to conventional regimen of proton pump inhibitors in controlling upper GI bleeding in pediatric population.Methods: In a prospective randomized controlled clinical trial, in Mofid Children's Hospital, Tehran, Iran, pediatric patients with age of 0 to 15 years diagnosed with acute non-variceal upper GI bleeding allocated to receive Octreotide or placebo and pantoprazole concomitantly. Medication administration initiated after patient’s stabilization. Patients with hepatic failure, liver stigma, coagulopathy thrombocytopenia etc. were excluded. Demographic, clinical and preclinical data were recorded in prepared sheets. All patients were followed until therapy discontinuation.Results: Forty-three patients with the mean age of 4.98 ± 3.79 years with confirmed non-variceal upper GI bleeding included to the study. Most patients had no specific etiology for their bleeding episode. Patients in intervention and control group received pantoprazole in comparable doses. No differences in baseline hemoglobin values was observed but final hemoglobin values were higher in intervention group. No differences in bleeding duration observed. In regard of adverse drug reaction due to octreotide infusion, none was observed in any patient. Conclusions: Our study demonstrated that octreotide does not alter bleeding duration but need for transfusion in non-variceal upper GI bleeding but it may have effect on amount of blood loss.Trial registration: The study was registered in Iranian Registry of Clinical Trial by the code of IRCT20120415009475N6.

A randomized controlled trial of laparoscopic extraperitoneal hernia repair as a day surgical procedure

1996 ◽  
Vol 10 (5) ◽  
pp. 495-500 ◽  
Author(s):  
J. R. Bessell ◽  
P. Baxter ◽  
P. Riddell ◽  
S. Watkin ◽  
G. J. Maddern
Keyword(s):  
Randomized Controlled Trial ◽  
Hernia Repair ◽  
Surgical Procedure ◽  
Controlled Trial ◽  
Randomized Controlled

The Efficacy of Cap-Assisted Colonoscopy as Compared to Conventional in a Pediatric Population: A Randomized Controlled Trial

2020 ◽  
Vol 103 (5) ◽  
pp. 428-433
Keyword(s):  
Randomized Controlled Trial ◽  
Quality Indicators ◽  
Pediatric Population ◽  
Controlled Trial ◽  
Common Indication ◽  
Randomized Controlled ◽  
Colonoscopy Quality ◽  
Standard Colonoscopy ◽  
Ileal Intubation

Background: The use of cap-assisted colonoscopy (CAC) in adults reportedly shortens cecal and ileal intubation times (CIT and IIT, respectively) and improves cecal and ileal intubation rates (CIR and IIR, respectively) as compared with the standard colonoscopy (SC). However, no study to date has assessed the efficacy of CAC in children. Materials and Methods: Thirty-nine children were randomized to CAC (n=22) or SC (n=17) and 22 colonoscopy procedure were done per group. Quality indicators were evaluated. Results: The median ages of the CAC and SC groups were 9.5 years (range 4.3 to 16.0) and 9.7 years (range 3.9 to 13.5), respectively. The most common indication was hematochezia (38.6%). The median CIT in the CAC and SC groups were 13.5 (range 8 to 19) and 13.7 (range 10 to 18) minutes, respectively (p=0.621). The IIT in the CAC and SC group were 60 (range 55 to 95) and 59 (range 35 to 95) seconds, respectively (p=0.438). The overall CIR was 100% and did not differ between groups. The IIR of the CAC and SC groups were 100% and 95.5%, respectively (p>0.999). Good CIR and IIR were achieved and no complications occurred in either group. Conclusion: There were no intergroup differences in quality indicators. Keywords: Cap-assisted colonoscopy, Quality indicators for colonoscopy, Pediatric

Treatment Fidelity Procedures for an Aphasia Intervention Within a Randomized Controlled Trial: Design, Feasibility, and Results

2020 ◽  
Vol 29 (1S) ◽  
pp. 412-424
Author(s):  
Elissa L. Conlon ◽  
Emily J. Braun ◽  
Edna M. Babbitt ◽  
Leora R. Cherney
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Treatment Protocol ◽  
Treatment Fidelity ◽  
Protocol Adherence ◽  
Study Condition ◽  
Randomized Controlled ◽  
Aphasia Therapy ◽  
Percent Accuracy ◽  
Over Time

Purpose This study reports on the treatment fidelity procedures implemented during a 5-year randomized controlled trial comparing intensive and distributed comprehensive aphasia therapy. Specifically, the results of 1 treatment, verb network strengthening treatment (VNeST), are examined. Method Eight participants were recruited for each of 7 consecutive cohorts for a total of 56 participants. Participants completed 60 hr of aphasia therapy, including 15 hr of VNeST. Two experienced speech-language pathologists delivered the treatment. To promote treatment fidelity, the study team developed a detailed manual of procedures and fidelity checklists, completed role plays to standardize treatment administration, and video-recorded all treatment sessions for review. To assess protocol adherence during treatment delivery, trained research assistants not involved in the treatment reviewed video recordings of a subset of randomly selected VNeST treatment sessions and completed the fidelity checklists. This process was completed for 32 participants representing 2 early cohorts and 2 later cohorts, which allowed for measurement of protocol adherence over time. Percent accuracy of protocol adherence was calculated across clinicians, cohorts, and study condition (intensive vs. distributed therapy). Results The fidelity procedures were sufficient to promote and verify a high level of adherence to the treatment protocol across clinicians, cohorts, and study condition. Conclusion Treatment fidelity strategies and monitoring are feasible when incorporated into the study design. Treatment fidelity monitoring should be completed at regular intervals during the course of a study to ensure that high levels of protocol adherence are maintained over time and across conditions.

Phonomotor Versus Semantic Feature Analysis Treatment for Anomia in 58 Persons With Aphasia: A Randomized Controlled Trial

2019 ◽  
Vol 62 (12) ◽  
pp. 4464-4482 ◽  
Author(s):  
Diane L. Kendall ◽  
Megan Oelke Moldestad ◽  
Wesley Allen ◽  
Janaki Torrence ◽  
Stephen E. Nadeau
Keyword(s):  
Randomized Controlled Trial ◽  
Response Latency ◽  
Controlled Trial ◽  
Semantic Knowledge ◽  
Semantic Feature ◽  
Feature Analysis ◽  
Group Differences ◽  
Randomized Controlled ◽  
Confrontation Naming ◽  
Semantic Feature Analysis

Purpose The ultimate goal of anomia treatment should be to achieve gains in exemplars trained in the therapy session, as well as generalization to untrained exemplars and contexts. The purpose of this study was to test the efficacy of phonomotor treatment, a treatment focusing on enhancement of phonological sequence knowledge, against semantic feature analysis (SFA), a lexical-semantic therapy that focuses on enhancement of semantic knowledge and is well known and commonly used to treat anomia in aphasia. Method In a between-groups randomized controlled trial, 58 persons with aphasia characterized by anomia and phonological dysfunction were randomized to receive 56–60 hr of intensively delivered treatment over 6 weeks with testing pretreatment, posttreatment, and 3 months posttreatment termination. Results There was no significant between-groups difference on the primary outcome measure (untrained nouns phonologically and semantically unrelated to each treatment) at 3 months posttreatment. Significant within-group immediately posttreatment acquisition effects for confrontation naming and response latency were observed for both groups. Treatment-specific generalization effects for confrontation naming were observed for both groups immediately and 3 months posttreatment; a significant decrease in response latency was observed at both time points for the SFA group only. Finally, significant within-group differences on the Comprehensive Aphasia Test–Disability Questionnaire ( Swinburn, Porter, & Howard, 2004 ) were observed both immediately and 3 months posttreatment for the SFA group, and significant within-group differences on the Functional Outcome Questionnaire ( Glueckauf et al., 2003 ) were found for both treatment groups 3 months posttreatment. Discussion Our results are consistent with those of prior studies that have shown that SFA treatment and phonomotor treatment generalize to untrained words that share features (semantic or phonological sequence, respectively) with the training set. However, they show that there is no significant generalization to untrained words that do not share semantic features or phonological sequence features.

Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial

2001 ◽  
Vol 26 (1) ◽  
pp. 67-71 ◽  
Author(s):  
S. A. Ahmadi-Abhari ◽  
S. Akhondzadeh ◽  
S. M. Assadi ◽  
O. L. Shabestari ◽  
Z. M. Farzanehgan ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Side Effects ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled
Sign in / Sign up

Export Citation Format

Share Document