Toward a new nosology for non-24-hour sleep-wake rhythm disorder

2021 ◽  
Author(s):  
Jonathan S. Emens ◽  
Elizabeth B. Klerman ◽  
Charles A. Czeisler
Keyword(s):  
Rhythm Disorder

CHALLENGES OF PATIENTS WITH PACEMAKER FOR IPSILATERAL BREAST CONSERVING SURGERY FOR CARCINOMA BREAST – A CASE SERIES

2021 ◽  
pp. 30-31
Author(s):  
Anita Kulkarni ◽  
Soumi Pathak
Keyword(s):  
Cancer Treatment ◽  
Case Series ◽  
Breast Conserving Surgery ◽  
Ipsilateral Breast ◽  
Carcinoma Breast ◽  
Rhythm Disorder

Pacemakers, implanted cardiac debrillators and ventricular assisted devices are frequently used for managing heart failures and patients with rhythm disorder. While managing such patients coming for oncosurgeries and cancer treatment, there are several issues related to equipment characteristic whose understanding is a must for the anaesthesiologist. There is a possibility of malfunctioning of these devices, however timely intervention can prevent catastrophic outcomes.

Management of insomnia and circadian rhythm sleep–wake disorders

2020 ◽  
pp. 1167-1178
Author(s):  
Simon D. Kyle ◽  
Alasdair L. Henry ◽  
Colin A. Espie
Keyword(s):  
Circadian Rhythm ◽  
Evidence Based ◽  
Sleep Wake Disorders ◽  
Insomnia Disorder ◽  
Cognitive Behavioural ◽  
Melatonin Administration ◽  
Evidence Based Treatments ◽  
Rhythm Disorder ◽  
Delayed Sleep ◽  
Behavioural Therapies

Insomnia disorder and circadian rhythm sleep–wake disorders (CRSWDs) are prevalent and impairing sleep disorders and often co-present with psychiatric disorder. Insomnia is characterized by difficulty with initiation and/or maintenance of sleep, driven primarily by cognitive behavioural processes. CRSWDs manifest because of alterations to the endogenous circadian clock (intrinsic) or as a consequence of environmental circumstances (extrinsic). This chapter reviews evidence-based treatments for the management of insomnia and intrinsic CRSWDs (delayed sleep–wake phase disorder, advanced sleep–wake phase disorder, non-24-hour sleep–wake disorder, irregular sleep–wake rhythm disorder). The chapter covers cognitive behavioural therapies, sleep-promoting hypnotics, phototherapy, and exogenous melatonin administration. The chapter also highlight gaps in the existing clinical science and reflects on emergent therapeutic approaches.

RESPONSE TO TREATMENT WITH LEMBOREXANT: SUBJECTS WITH IRREGULAR SLEEP-WAKE RHYTHM DISORDER AND ALZHEIMER’S DISEASE DEMENTIA

2019 ◽  
Vol 15 (7) ◽  
pp. P187 ◽  
Author(s):  
Stephen G. Thein ◽  
Mohammad Bsharat ◽  
Manuel Kemethofer ◽  
Gleb Filippov ◽  
Naoki Kubota ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Response To Treatment ◽  
Rhythm Disorder ◽  
Alzheimer’S Disease Dementia

scholarly journals Genetics of Atrial Fibrillation in 2020

2020 ◽  
Vol 127 (1) ◽  
pp. 21-33 ◽  
Author(s):  
Carolina Roselli ◽  
Michiel Rienstra ◽  
Patrick T. Ellinor
Keyword(s):  
Atrial Fibrillation ◽  
Complex Disease ◽  
Association Studies ◽  
Heart Rhythm ◽  
Genome Wide Association Studies ◽  
Future Directions ◽  
Genetics Research ◽  
Genome Wide ◽  
Increased Risk ◽  
Rhythm Disorder

Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic risk factors that contribute to the arrhythmia. Over the last decade, rapid progress has been made in identifying the genetic basis for this common condition. In this review, we provide an overview of the primary types of genetic analyses performed for atrial fibrillation, including linkage studies, genome-wide association studies, and studies of rare coding variation. With these results in mind, we aim to highlighting the existing knowledge gaps and future directions for atrial fibrillation genetics research.

Non–24-hour Sleep-Wake Rhythm Disorder

2019 ◽  
Vol 37 (3) ◽  
pp. 545-552
Author(s):  
Sabra M. Abbott
Keyword(s):  
Rhythm Disorder

scholarly journals Circadian tau differences and rhythm associations in delayed sleep–wake phase disorder and sighted non-24-hour sleep–wake rhythm disorder

SLEEP ◽  
2020 ◽  
Author(s):  
Gorica Micic ◽  
Nicole Lovato ◽  
Sally A Ferguson ◽  
Helen J Burgess ◽  
Leon Lack
Keyword(s):  
Circadian Rhythm ◽  
Core Body Temperature ◽  
Sleep Onset ◽  
Phase Relationship ◽  
Biological Rhythms ◽  
Circadian Phase ◽  
Behavioral Rhythm ◽  
Rhythm Disorder ◽  
Dim Light ◽  
Delayed Sleep

Abstract Study Objectives We investigated biological and behavioral rhythm period lengths (i.e. taus) of delayed sleep–wake phase disorder (DSWPD) and non-24-hour sleep–wake rhythm disorder (N24SWD). Based on circadian phase timing (temperature and dim light melatonin onset), DSWPD participants were dichotomized into a circadian-delayed and a circadian non-delayed group to investigate etiological differences. Methods Participants with DSWPD (n = 26, 17 m, age: 21.85 ± 4.97 years), full-sighted N24SWD (n = 4, 3 m, age: 25.75 ± 4.99 years) and 18 controls (10 m, age: 23.72 ± 5.10 years) participated in an 80-h modified constant routine. An ultradian protocol of 1-h “days” in dim light, controlled conditions alternated 20-min sleep/dark periods with 40-min enforced wakefulness/light. Subjective sleepiness ratings were recorded prior to every sleep/dark opportunity and median reaction time (vigilance) was measured hourly. Obtained sleep (sleep propensity) was derived from 20-min sleep/dark opportunities to quantify hourly objective sleepiness. Hourly core body temperature was recorded, and salivary melatonin assayed to measure endogenous circadian rhythms. Rhythm data were curved using the two-component cosine model. Results Patients with DSWPD and N24SWD had significantly longer melatonin and temperature taus compared to controls. Circadian non-delayed DSWPD had normally timed temperature and melatonin rhythms but were typically sleeping at relatively late circadian phases compared to those with circadian-delayed DSWPD. Conclusions People with DSWPD and N24SWD exhibit significantly longer biological circadian rhythm period lengths compared to controls. Approximately half of those diagnosed with DSWPD do not have abnormally delayed circadian rhythm timings suggesting abnormal phase relationship between biological rhythms and behavioral sleep period or potentially conditioned sleep-onset insomnia.

scholarly journals Recommendations for participation in leisure-time physical activity and competitive sports of patients with arrhythmias and potentially arrhythmogenic conditions. Part 2: ventricular arrhythmias, channelopathies, and implantable defibrillators

EP Europace ◽  
2020 ◽  
Author(s):  
Hein Heidbuchel ◽  
Elena Arbelo ◽  
Flavio D’Ascenzi ◽  
Mats Borjesson ◽  
Serge Boveda ◽  
...  
Keyword(s):  
Physical Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Heart Rhythm ◽  
Competitive Sports ◽  
Supraventricular Arrhythmias ◽  
Preventive Cardiology ◽  
Structural Problems ◽  
Rhythm Disorder ◽  
Implanted Pacemaker

Abstract This paper belongs to a series of recommendation documents for participation in leisure-time physical activity and competitive sports by the European Association of Preventive Cardiology (EAPC). Together with an accompanying paper on supraventricular arrhythmias, this second text deals specifically with those participants in whom some form of ventricular rhythm disorder is documented, who are diagnosed with an inherited arrhythmogenic condition, and/or who have an implanted pacemaker or cardioverter defibrillator. A companion text on recommendations in athletes with supraventricular arrhythmias is published in the European Journal of Preventive Cardiology. Since both texts focus on arrhythmias, they are the result of a collaboration between EAPC and the European Heart Rhythm Association (EHRA). The documents provide a framework for evaluating eligibility to perform sports, based on three elements, i.e. the prognostic risk of the arrhythmias when performing sports, the symptomatic impact of arrhythmias while performing sports, and the potential progression of underlying structural problems as the result of sports.

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