scholarly journals Treatment of central disorders of hypersomnolence: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment

2021 ◽  
Author(s):  
Kiran Maski ◽  
Lynn Marie Trotti ◽  
Suresh Kotagal ◽  
Robert R Auger ◽  
James A Rowley ◽  
...  
Keyword(s):  
Systematic Review ◽  
American Academy ◽  
Meta Analysis ◽  
Sleep Medicine ◽  
Grade Assessment

scholarly journals Publisher Correction: Exercise for improving age-related hyperkyphosis: a systematic review and meta-analysis with GRADE assessment

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Matteo Ponzano ◽  
Nicholas Tibert ◽  
Symron Bansal ◽  
Wendy Katzman ◽  
Lora Giangregorio
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Age Related ◽  
Grade Assessment

Exercise for improving age-related hyperkyphosis: a systematic review and meta-analysis with GRADE assessment

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Matteo Ponzano ◽  
Nicholas Tibert ◽  
Symron Bansal ◽  
Wendy Katzman ◽  
Lora Giangregorio
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Age Related ◽  
Grade Assessment

scholarly journals The association between silica exposure, silicosis and tuberculosis: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rodney Ehrlich ◽  
Paula Akugizibwe ◽  
Nandi Siegfried ◽  
David Rees
Keyword(s):  
Systematic Review ◽  
Relative Risk ◽  
Pulmonary Tuberculosis ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Inclusion Criteria ◽  
Silica Exposure ◽  
Exposure Response ◽  
Increased Risk ◽  
Grade Assessment

Abstract Background While the association between occupational inhalation of silica dust and pulmonary tuberculosis has been known for over a century, there has never been a published systematic review, particularly of experience in the current era of less severe silicosis and treatable tuberculosis. We undertook a systematic review of the evidence for the association between (1) silicosis and pulmonary tuberculosis, and (2) silica exposure and pulmonary tuberculosis controlling for silicosis, and their respective exposure-response gradients. Methods We searched PUBMED and EMBASE, and selected studies according to a priori inclusion criteria. We extracted, summarised and pooled the results of published case-control and cohort studies of silica exposure and/or silicosis and incident active tuberculosis. Study quality was assessed on the Newcastle-Ottawa Scale. Where meta-analysis was possible, effect estimates were pooled using inverse-variance weighted random-effects models. Otherwise narrative and graphic synthesis was undertaken. Confidence regarding overall effect estimates was assessed using the GRADE schema. Results Nine studies met the inclusion criteria. Meta-analysis of eight studies of silicosis and tuberculosis yielded a pooled relative risk of 4.01 (95% confidence interval (CI) 2.88, 5.58). Exposure-response gradients were strong with a low silicosis severity threshold for increased risk. Our GRADE assessment was high confidence in a strong association. Meta-analysis of five studies of silica exposure controlling for or excluding silicosis yielded a pooled relative risk of 1.92 (95% CI 1.36, 2.73). Exposure-response gradients were observable in individual studies but not finely stratified enough to infer an exposure threshold. Our GRADE assessment was low confidence in the estimated effect owing to inconsistency and use of proxies for silica exposure. Conclusions The evidence is robust for a strongly elevated risk of tuberculosis with radiological silicosis, with a low disease severity threshold. The effect estimate is more uncertain for silica exposure without radiological silicosis. Research is needed, particularly cohort studies measuring silica exposure in different settings, to characterise the effect more accurately as well as the silica exposure threshold that could be used to prevent excess tuberculosis risk.

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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