Non-REM sleep predominant reversible paradoxical breathing effort indicating dysregulation of diaphragm movements in multiple system atrophy

2021 ◽  
Author(s):  
Jongmok Ha ◽  
Jaehong Park ◽  
Jinyoung Youn ◽  
Jin Whan Cho ◽  
Eun Yeon Joo
Keyword(s):  
Multiple System Atrophy ◽  
Rem Sleep ◽  
Paradoxical Breathing ◽  
Breathing Effort

Status dissociatus evolving from REM sleep behaviour disorder in multiple system atrophy

2009 ◽  
Vol 10 (2) ◽  
pp. 247-252 ◽  
Author(s):  
Roberto Vetrugno ◽  
Maria Alessandria ◽  
Roberto D’Angelo ◽  
Giuseppe Plazzi ◽  
Federica Provini ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Rem Sleep ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

scholarly journals REM Sleep Behaviour Disorder in Multiple System Atrophy: From Prodromal to Progression of Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Giulia Giannini ◽  
Federica Provini ◽  
Pietro Cortelli ◽  
Giovanna Calandra-Buonaura
Keyword(s):  
Multiple System Atrophy ◽  
Rem Sleep ◽  
Autonomic Failure ◽  
Disease Onset ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Disease Modifying Therapies ◽  
Rem Sleep Behaviour Disorder ◽  
Progression Of Disease

A higher frequency of motor and breathing sleep-related disorders in multiple system atrophy (MSA) populations is reported. REM sleep behaviour disorder (RBD) is one of the most robust markers of an underlying alpha-synucleinopathy. Although a large corpus of literature documented the higher prevalence of RBD in MSA, few studies have systematically investigated the prevalence of RBD as mode of disease onset and its role in disease progression. Moreover, there has been increasing interest in phenoconversion into synucleinopathies of cohorts of patients with isolated RBD (iRBD). Finally, some studies investigated RBD as predictive factor of conversion in isolated autonomic failure, a synucleinopathy presenting with autonomic failure as the sole clinical manifestation that could convert to a manifest central nervous system synucleinopathy. As the field of neurodegenerative disorders moves increasingly towards developing disease-modifying therapies, detecting individuals in the prodromal stage of these synucleinopathies becomes crucial. The aims of this review are to summarise (1) the prevalence of RBD during the course of MSA and as presenting feature of MSA (iRBD), (2) the RBD features in MSA, (3) MSA progression and prognosis in the subgroup of patients with RBD predating disease onset, and (4) the prevalence of MSA conversion in iRBD cohorts. Moreover, we summarise previous results on the role of RBD in the context of isolated autonomic failure as marker of phenoconversion to other synucleinopathies and, in particular, to MSA.

REM sleep behavior disorders in multiple system atrophy

Neurology ◽  
1997 ◽  
Vol 48 (4) ◽  
pp. 1094-1096 ◽  
Author(s):  
G. Plazzi ◽  
R. Corsini ◽  
F. Provini ◽  
G. Pierangeli ◽  
P. Martinelli ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Rem Sleep ◽  
Behavior Disorders ◽  
Sleep Behavior

Age related progression and homeostatic susceptibility of REM-sleep behavioral disorder symptoms in a mouse model for multiple system atrophy

2017 ◽  
Vol 40 ◽  
pp. e127
Author(s):  
L. Härtner ◽  
V. Leis ◽  
M. Kreuzer ◽  
G. Wenning ◽  
N. Stefanova ◽  
...  
Keyword(s):  
Mouse Model ◽  
Multiple System Atrophy ◽  
Rem Sleep ◽  
Behavioral Disorder ◽  
Age Related
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