scholarly journals Central Sleep Apnea With Sodium Oxybate in a Pediatric Patient

2019 ◽  
Vol 15 (03) ◽  
pp. 515-517 ◽  
Author(s):  
Arezou Heshmati
Keyword(s):  
Sleep Apnea ◽  
Pediatric Patient ◽  
Central Sleep Apnea ◽  
Sodium Oxybate

scholarly journals 1068 Severe Central Sleep Apnea in a Pediatric Patient with Klippel-Feil Syndrome

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A427-A428 ◽  
Author(s):  
L Goldman ◽  
F Hassan
Keyword(s):  
Sleep Apnea ◽  
Pediatric Patient ◽  
Central Sleep Apnea

scholarly journals 1238 Central sleep apnea with Cheyne Stokes breathing in a pediatric patient with heart failure

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A472-A472
Author(s):  
Weston T Powell ◽  
Maida Chen ◽  
Erin MacKintosh
Keyword(s):  
Heart Failure ◽  
Sleep Apnea ◽  
Heart Transplantation ◽  
Dilated Cardiomyopathy ◽  
Acute Heart Failure ◽  
Pediatric Patient ◽  
Central Sleep Apnea ◽  
Supplemental Oxygen ◽  
Adult Patients ◽  
Cheyne Stokes Breathing

Abstract Introduction Central sleep apnea due to Cheyne-Stokes breathing (CSA-CSB) commonly occurs in adult patients with chronic heart failure, but has rarely been described in children. We describe a case of CSA-CSB in a pediatric patient with dilated cardiomyopathy and acute heart failure. Report of Case A 12-year-old is admitted to the intensive care unit in the setting of new diagnosis of dilated cardiomyopathy leading to acute systolic and diastolic heart failure requiring inotropic infusions. After admission she is noted to have self-resolving desaturations on continuous pulse oximetry while asleep. Sleep medicine is consulted for further evaluation. She has desaturations during naps and night-time sleep that are not associated with any snoring, congestion, cough, choking, or gagging. She underwent adenotonsillectomy 7 years prior. Her father has dilated cardiomyopathy. Current medications are spironolactone, furosemide, ranitidine, loratadine, enoxaparin, milrinone and epinephrine infusion. Physical exam reveals an obese girl with absent tonsils, clear breath sounds, and tachycardia. Cardiac MRI showed severely dilated left ventricle with global hypokinesia and depressed function (EF 7%). Polysomnography reveals AHI 24.2/hr, with oAHI 0/hr and cAHI 24.2/hr. No snoring, flow limitation, or thoracoabdominal paradox is seen. Cheyne-Stokes respiration is present leading to diagnosis of CSA-CSB. Supplemental oxygen is provided to blunt desaturations. While waiting for titration PSG she underwent placement of a left ventricular assist device and orthotopic heart transplantation. Following heart transplantation she had resolution of desaturations while asleep without supplemental oxygen; family declined repeat polysomnography. Conclusion Central sleep apnea with Cheyne-Stokes breathing is associated with increased mortality in adult patients with heart failure and provides important prognostic information if identified. The prevalence of central sleep apnea and its implications are unknown in pediatric patients and our case highlights the need to consider sleep disordered breathing as a cause of desaturations in patients with acute heart failure.

scholarly journals 1144 Central Sleep Apnea in a Pediatric Patient With Acute Heart Failure

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A423-A423
Author(s):  
Sonal Malhotra ◽  
Goutham Gudavalli ◽  
Kevin Kaplan
Keyword(s):  
Heart Failure ◽  
Sleep Apnea ◽  
Acute Heart Failure ◽  
Pediatric Patient ◽  
Central Sleep Apnea

scholarly journals 1107 Central Sleep Apnea with Cheyne-Stokes Respiration Associated with Sodium Oxybate Use

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A411-A411 ◽  
Author(s):  
Alok Sachdeva ◽  
Abbey E Dunn ◽  
Neeraj Kaplish
Keyword(s):  
Sleep Apnea ◽  
Central Sleep Apnea ◽  
Sodium Oxybate

826 Central Sleep Apnea associated with Sodium Oxybate– A Case Series

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A322-A322
Author(s):  
Subhendu Rath ◽  
Lizabeth Binns ◽  
Neeraj Kaplish
Keyword(s):  
Sleep Apnea ◽  
Sleep Onset ◽  
Case Series ◽  
Central Sleep Apnea ◽  
Sodium Oxybate ◽  
Close Monitoring ◽  
Sleep Study ◽  
Adaptive Servo Ventilation ◽  
Obstructive Sleep ◽  
Titration Study

Abstract Introduction Sodium oxybate (SO) is indicated to treat cataplexy and excessive daytime sleepiness (EDS) in patients with narcolepsy. Only a handful of cases have been reported of new-onset Central Sleep Apnea (CSA) in the setting of SO use. We present 3 patients who developed CSA in the setting of use of SO. Report of case(s) Patient 1: A 25-y/o man presented with hypersomnolence. His diagnostic polysomnogram (PSG) showed moderate Obstructive Sleep Apnea (OSA), and he was placed on Continuous Positive Airway Pressure (CPAP) therapy. Due to persistent hypersomnia in the setting of effectively treated OSA, he had a Multiple Sleep Latency Test (MSLT), which revealed pathological sleepiness with a mean latency of 3.8 minutes with a sleep-onset REM on the overnight polysomnogram. SO was started for clinical diagnosis of Narcolepsy after he failed other stimulant medications. Hypersomnolence improved though data from his PAP device, home sleep studies, re-titration studies performed when he was on SO demonstrated CSA following 1st or 2nd dose of SO. Patient 2: A 17-y/o man was diagnosed to have Narcolepsy with Cataplexy, based on PSG followed by MSLT. 20 years later, he was diagnosed with OSA based on a PSG and was treated with CPAP. A few years later, he was started on SO for fragmented sleep and EDS. A home sleep study performed when he was on SO, revealed CSA. Later, an in-lab titration study showed CSA with Cheyne-Stokes respiration (CSR), treated with Adaptive Servo-Ventilation (ASV) therapy. Patient 3: A 15-y/o man initially presented after several cataplectic episodes and was diagnosed with Narcolepsy with Cataplexy. His initial PSG showed no evidence of sleep-disordered breathing. A few years later, for persistent cataplectic events, he was started on SO with improvement in the episodes’ frequency. Several years later, a baseline PSG demonstrated OSA and CSA, with frequent CSA events soon after taking SO. The CPAP titration study, performed following the PSG, also revealed frequent CSA following the second dose of SO. Conclusion Close monitoring is warranted with SO use, given some narcolepsy patients’ predisposition to develop CSA. Follow-up studies are needed to address the pathogenesis and management strategies. Support (if any) None

Central Sleep Apnea in Heart Failure

2009 ◽  
Vol 6 (2) ◽  
pp. 72-78 ◽  
Author(s):  
Rami Khayat ◽  
Andrew Pederzoli ◽  
William Abraham ◽  
◽  
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...  
Keyword(s):  
Heart Failure ◽  
Sleep Apnea ◽  
Central Sleep Apnea

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