scholarly journals Sleep Architecture Following a Weight Loss Intervention in Overweight and Obese Patients with Obstructive Sleep Apnea and Type 2 Diabetes: Relationship to Apnea-Hypopnea Index

2014 ◽  
Vol 10 (11) ◽  
pp. 1205-1211 ◽  
Author(s):  
Ari Shechter ◽  
Marie-Pierre St-Onge ◽  
Samuel T. Kuna ◽  
Gary Zammit ◽  
Arindam RoyChoudhury ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Weight Loss ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Architecture ◽  
Apnea Hypopnea Index ◽  
Obese Patients ◽  
Weight Loss Intervention ◽  
Obstructive Sleep

scholarly journals Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Wanwan Wen ◽  
Haili Sun ◽  
Yunxiao Yang ◽  
Yifan Jia ◽  
Fang Fang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Fasting Blood Glucose ◽  
Area Under The Curve ◽  
Cathepsin S ◽  
Control Group ◽  
Apnea Hypopnea Index ◽  
Obstructive Sleep

Background. Obstructive sleep apnea (OSA) was highly prevalent in patients with type 2 diabetes (T2D). Cathepsin S (CTSS), a cysteine protease, is involved in the inflammatory activity in T2D and hypoxia conditions. The aim of the study was to evaluate whether CTSS could be involved in the inflammatory reaction of OSA in patients with T2D. Methods. We included 158 participants in this study matched for age, gender, and body mass index in 4 groups (control, non-OSA&T2D, OSA&non-T2D, and OSA&T2D). After overnight polysomnography, we collected the clinical data including anthropometrical characteristics, blood pressure, and fasting blood samples in the morning. Plasma CTSS concentration was evaluated using the human Magnetic Luminex Assay. Results. Compared with the control group, both the non-OSA&T2D group and the OSA&non-T2D group showed higher CTSS levels. Plasma CTSS expression was significantly increased in subjects with OSA&T2D compared to subjects with non-OSA&T2D. The OSA&T2D group had higher CTSS levels than the OSA&non-T2D group, but there were no statistically significant differences. Plasma CTSS levels showed significant correlation with the apnea-hypopnea index (AHI) (r=0.559, P<0.001) and plasma fasting blood glucose (r=0.427, P<0.001). After adjusting confounding factors, plasma CTSS levels were independently associated with the AHI (Beta: 0.386, 95% confidence intervals (CI): 21.988 to 57.781; P<0.001). Furthermore, we confirmed the higher pinpoint accuracy of plasma CTSS in the diagnosis of OSA (area under the curve: 0.868). Conclusions. Plasma CTSS expression was significantly elevated in the OSA&T2D group and was independently associated with the AHI; it could be a biomarker with a positive diagnostic value on diagnosing OSA among patients with T2D.

scholarly journals Nocturnal Oxygen Saturation Parameters as Independent Risk Factors for Type 2 Diabetes Mellitus among Obstructive Sleep Apnea Patients

2021 ◽  
Vol 10 (17) ◽  
pp. 3770
Author(s):  
Agata Gabryelska ◽  
Jędrzej Chrzanowski ◽  
Marcin Sochal ◽  
Piotr Kaczmarski ◽  
Szymon Turkiewicz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Oxygen Saturation ◽  
Cox Regression ◽  
Apnea Hypopnea Index ◽  
Cart Analysis ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) is a recognized independent risk factor for metabolic disorders, type 2 diabetes mellites (DM2) in particular. Therefore, the study aimed to assess the influence of nocturnal oxygen saturation parameters on the onset of DM2 among OSA patients. The study consisted of 549 participants, who underwent polysomnography examination. Based on apnea hypopnea index (AHI), 465 patients were diagnosed with OSA. One hundred and seven individuals had comorbid DM2. Cox regression models were used to assess the effect of oxygen saturation parameters on the onset of DM2. Classification and regression trees (CART) analysis was used to assess the onset of the DM2 in the study group in context of oxygen saturation variables. One-way Cox regression showed higher risk of earlier DM2 for increased values of BMI, AHI, decreased basal O2 and O2 nadir value, while lowered mean O2 desaturation has not shown statistical significance. In the CART analysis, the following cut-off points 92.2%, 81.7%, 87.1% were determined for basal O2, O2 nadir and mean O2 desaturation, respectively, with the first two parameters being statistically significant. Therefore, basal O2 is independent from AHI, BMI and age is a risk factor of DM2 among OSA patients.

scholarly journals Long-Term Effect of Weight Loss on Obstructive Sleep Apnea Severity in Obese Patients with Type 2 Diabetes

SLEEP ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. 641-649 ◽  
Author(s):  
Samuel T. Kuna ◽  
David M. Reboussin ◽  
Kelley E. Borradaile ◽  
Mark H. Sanders ◽  
Richard P. Millman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Weight Loss ◽  
Obstructive Sleep Apnea ◽  
Term Effect ◽  
Obese Patients ◽  
Long Term Effect ◽  
Obstructive Sleep Apnea Severity ◽  
Obstructive Sleep

scholarly journals Obstructive sleep apnea syndrome causes a pseudo-Cushing^|^rsquo;s state in Japanese obese patients with type 2 diabetes mellitus

2013 ◽  
Vol 60 (12) ◽  
pp. 1289-1294 ◽  
Author(s):  
Daisuke Tamada ◽  
Michio Otsuki ◽  
Susumu Kashine ◽  
Ayumu Hirata ◽  
Toshiharu Onodera ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Obstructive Sleep Apnea ◽  
Type 2 Diabetes Mellitus ◽  
Sleep Apnea ◽  
Sleep Apnea Syndrome ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Obstructive Sleep Apnea Among Obese Patients With Type 2 Diabetes

Diabetes Care ◽  
2009 ◽  
Vol 32 (6) ◽  
pp. 1017-1019 ◽  
Author(s):  
G. D. Foster ◽  
M. H. Sanders ◽  
R. Millman ◽  
G. Zammit ◽  
K. E. Borradaile ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obese Patients ◽  
Obstructive Sleep
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