scholarly journals Regulation of Plasma Phosphate Concentration and Diurnal Rhythm

Oleoscience ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 135-140
Author(s):  
Sawako TATSUMI ◽  
Shoji KUWAHARA ◽  
Hiroko SEGAWA ◽  
Ken-ichi MIYAMOTO
Keyword(s):  
Diurnal Rhythm ◽  
Phosphate Concentration ◽  
Plasma Phosphate

scholarly journals Relationships between phosphatemia/phosphaturia and EEG/HRV parameters in patients with chronic pyelonephritis

2021 ◽  
Vol 11 (2) ◽  
pp. 335-346
Author(s):  
Anatoliy Kushneruk ◽  
Anatoliy Gozhenko ◽  
Walery Zukow ◽  
Igor Popovych
Keyword(s):  
Kidney Disease ◽  
Canonical Correlation ◽  
Phosphate Concentration ◽  
Chronic Pyelonephritis ◽  
Plasma Phosphate ◽  
Wide Range ◽  
Daily Urine ◽  
Calcium Exchange ◽  
Causal Nature ◽  
Phosphate Exchange

Background. As part of the project "Relationships between parameters of electrolytes exchange and EEG&HRV in people without kidney disease and patients with chronic pyelonephritis" we have previously shown that parameters of calcium exchange and EEG/HRV are closely related. In this study, we analyzed the relationships between parameters of phosphate exchange and EEG/HRV in the same cohort of patients. Material and methods. The object of observation were 48 males and 15 females 24-76 years old, who came to the spa Truskavets’ (Ukraine) for the treatment of chronic pyelonephritis in remission. We recorded simultaneosly EEG (“NeuroCom Standard”) and electrocardiogram ("CardioLab+HRV") in II lead to assess the parameters of HRV. Phosphate concentration was determined in blood plasma and daily urine. Results. It was stated normal or moderately reduced plasma phosphate levels in combination with a very wide range of phosphate urinary excretion. A very strong canonical correlation was found between phosphatemia and EEG/HRV parameters (R=0,982). The correlations with the parameters of the beta and theta rhythms of the EEG and the HRV are positive, while with the parameters of the delta rhythm of the EEG are negative. The canonical correlation between phosphaturia and EEG parameters is also very strong (R=0,879). Conclusion. Parameters of phosphate exchange and EEG/HRV are closely related, however the question of the causal nature of correlations remains open.

Interrelations of arsenate and phosphate transport in the dog kidney

1963 ◽  
Vol 205 (4) ◽  
pp. 707-714 ◽  
Author(s):  
J. M. Ginsburg ◽  
W. D. Lotspeich
Keyword(s):  
Phosphate Transport ◽  
Tubular Secretion ◽  
Tubular Reabsorption ◽  
Urine Flow ◽  
Phosphate Concentration ◽  
Plasma Phosphate ◽  
Osmotic Diuresis ◽  
Competitive Mechanism ◽  
Dog Kidney

The relation between arsenate and phosphate transport in the dog kidney was studied by measuring the renal clearance of arsenate labeled with its radioactive isotope As74. The experiments were performed during osmotic diuresis induced by mannitol. The results demonstrate certain similarities in the transport of these ions. Arsenate undergoes a net tubular reabsorption which is inhibited as the plasma phosphate concentration is raised. The inverse relationship between arsenate transport and the plasma As:P ratio suggests a competitive mechanism for the interaction between the two ions Like phosphate, arsenate transport is inhibited by glucose and this effect is reversed by phlorizin. An important difference between arsenate and phosphate transport is the sensitivity of arsenate transport to urine flow. In vivo reduction of arsenate to arsenite and a net tubular secretion of arsenite has been observed. The results are discussed in terms of the known ability of arsenate to substitute for phosphate in biochemical reactions.

Metabolic Effects of CAPD in the Child

1983 ◽  
Vol 3 (1_suppl) ◽  
pp. 21-23 ◽  
Author(s):  
John Williamson Balfe
Keyword(s):  
Tube Feeding ◽  
Phosphate Concentration ◽  
Metabolic Effects ◽  
Phosphate Binders ◽  
Brain Growth ◽  
Plasma Phosphate ◽  
Failure Treatment ◽  
Supplemental Vitamin ◽  
Optimal Linear ◽  
Nasogastric Tube Feeding

CAPD can be used in children of all ages and sizes. Currently, it is the dialysis of choice at our center for young children. Even though a successful renal transplant is our ultimate goal, the best yardstick of successful renal failure treatment is optimal linear and brain growth. Proper and adequate nutrition are mandatory for growth. Nutrition should be approached aggressively in children who are receiving CAPD and yet have persistent anorexia. Nasogastric tube feeding or addition of nutrients to the dialysate may be necessary for such patients. Bone disease on CAPD can be prevented by providing the child with supplemental vitamin D, controlling the plasma phosphate concentration (dietary restriction or phosphate binders) and preventing hyperparathyroidism. Technical improvements will continue in the field of dialysis. Each new attempt at improved therapy should be approached carefully and should be assessed properly for its suitability in children.

Circadian Changes in Plasma Phosphate Concentration, Urinary Phosphate Excretion, and Cellular Phosphate Shifts

1992 ◽  
Vol 38 (3) ◽  
pp. 400-402 ◽  
Author(s):  
G J Kemp ◽  
A Blumsohn ◽  
B W Morris
Keyword(s):  
Extracellular Fluid ◽  
Phosphate Concentration ◽  
Confidence Limits ◽  
Plasma Phosphate ◽  
Circadian Changes ◽  
Cosinor Analysis ◽  
Phosphate Excretion ◽  
Net Fluxes

Abstract The concentration of phosphate (Pi) in plasma, Pi excretion, and the tubular threshold of Pi resorption (TmP/GFR) all increase throughout the day from about 1100 to 0300 h. For plasma [Pi], cosinor analysis yielded the following estimates of the parameters of this pattern (with 95% confidence limits): amplitude = 0.17 (0.07-0.26) mmol/L, phase = peak at 0201 (1127-0342) h, and MESOR = 1.14 (1.11-1.18) mmol/L. The increase in TmP/GFR reflects an underlying change in renal Pi handling, which is not attributable to changes in parathyrin concentrations. The changes in Pi excretion work both for and against the changes in plasma [Pi], at different times. The calculated net nonrenal flux of Pi into the extracellular fluid increases in the morning and remains high until 0300 h, and neither it nor Pi excretion nor plasma [Pi] shows any relation to meals. This illustrates the importance of transient net fluxes of Pi between intracellular and extracellular spaces in the control of hour-to-hour changes of plasma [Pi].

The effect of variation in phosphorus intake on salivary phosphorus secretion, net intestinal phosphorus absorption and faecal endogenous phosphorus excretion in sheep

1985 ◽  
Vol 105 (2) ◽  
pp. 271-277 ◽  
Author(s):  
D. Scott ◽  
F. G. Whitelaw ◽  
W. Buchan ◽  
L. A. Bruce
Keyword(s):  
Continuous Infusion ◽  
Phosphate Concentration ◽  
Plasma Phosphate ◽  
Major Pathway ◽  
Phosphorus Balance ◽  
Phosphorus Excretion ◽  
Phosphorus Absorption ◽  
Phosphorus Intake

SUMMARYMature sheep fitted with rumen and duodenal cannulae, and fed a pelleted hay diet, were given supplementary phosphorus by continuous infusion into the rumen and the effects on salivary phosphorus secretion, net intestinal phosphorus absorption and faecal endogenous phosphorus excretion were studied. In control periods little phosphorus was excreted in the urine and little increase was seen in response to supplementation, the faeces being the major pathway for excretion. Increasing phosphorus intake led to an increase in net intestinal phosphorus absorption, a rise in plasma phosphate concentration, an increase in salivary phosphorus secretion and an increase in faecal endogenous phosphorus excretion. Overall net intestinal absorptive efficiency for phosphorus did, however, decrease as intake rose so that changes in faecal endogenous phosphorus excretion were in part due to increased salivary phosphorus secretion and in part to a reduction in overall absorptive efficiency. The significance of these changes in relation to the control of phosphorus balance in ruminants is discussed.

Absence of significant secretory flux of phosphate in the proximal convoluted tubule

1977 ◽  
Vol 232 (3) ◽  
pp. F235-F238 ◽  
Author(s):  
R. F. Greger ◽  
F. C. Lang ◽  
F. G. Knox ◽  
C. P. Lechene
Keyword(s):  
Parathyroid Hormone ◽  
Proximal Tubule ◽  
Renal Tubule ◽  
Phosphate Transport ◽  
Proximal Convoluted Tubule ◽  
Phosphate Concentration ◽  
Secretory Process ◽  
Plasma Phosphate ◽  
Sample Contamination ◽  
Intact Rats

The presence of phosphate secretion by the renal tubule in mammals has been controversial. Recently, in a micropuncture and microperfusion study, net secretion of phosphate was reported for the proximal tubule of rats which were infused with parathyroid hormone (PTH) and phosphate. Since the finding of net secretion of phosphate by the proximal tubule is in contradiction to other reports, the question was reinvestigated with the use of microperfusion techniques that were modified to allow identification of sample contamination. Studies were performed in intact dogs, phosphate- and PTH-loaded intact rats, and phosphate-loaded, acutely thyroparathyroidectomized rats. After exclusion of contaminated samples, no significant influx of phosphate was found in any of the three groups. Neither increased plasma phosphate concentration nor the infusion of parathyroid hormone unmasked a secretory process for phosphate. It is concluded that phosphate transport in the proximal tubule is essentially a unidirectional phenomenon, i.e., reabsorption is not opposed by significant backflux of phosphate.

scholarly journals Phosphate concentrations and modifying factors in healthy children from 12 to 24 months of age

2021 ◽  
Author(s):  
Laura Koljonen ◽  
Maria Enlund-Cerullo ◽  
Helena Hauta-alus ◽  
Elisa Holmlund-Suila ◽  
Saara Valkama ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Repeated Measurements ◽  
Phosphate Concentration ◽  
Healthy Children ◽  
Plasma Phosphate ◽  
Time Points ◽  
Modifying Factors ◽  
Healthy Infants ◽  
Vitamin D3 Supplementation

Abstract Context Phosphate homeostasis and its modifiers in early childhood are inadequately characterized. Objective To determine physiological plasma phosphate concentration and modifying factors in healthy infants at 12 to 24 months of age. Design This study included 525 healthy infants (53% girls), who participated in a randomized vitamin D intervention (VIDI) trial and received daily vitamin D3 supplementation of either 10 or 30 μg from age two weeks to 24 months. Biochemical parameters were measured at 12 and 24 months. Dietary phosphate intake was determined at 12 months. Main Outcome Measures Plasma phosphate concentrations at 12 and 24 months of age. Results Mean (SD) phosphate concentration decreased from 12 months (1.9±0.15 mmol/L) to 24 months (1.6±0.17 mmol/L) of age (p<0.001 for repeated measurements). When adjusted by covariates, such as body size, creatinine, 25OHD, intact and C-terminal FGF23, mean plasma phosphate was higher in boys than girls during follow-up (p=0.019). Phosphate concentrations were similar in the vitamin D intervention groups (p>0.472 for all). Plasma iron was associated positively with plasma phosphate at both time points (B, 0.006 and 0.005, 95% CI 0.004 to 0.009 and 0.002 to 0.008, p<0.001 at both time points, respectively). At 24 months of age, the main modifier of phosphate concentration was plasma creatinine (B, 0.007, 95% CI 0.003 to 0.011, p<0.001). Conclusion Plasma phosphate concentration decreased from age 12 to 24 months. In infants and toddlers, the strongest plasma phosphate modifiers were sex, iron, and creatinine, whereas vitamin D supplementation did not modify phosphate concentrations.

Effect of respiratory alkalosis on renal phosphate excretion

1982 ◽  
Vol 243 (5) ◽  
pp. F471-F475 ◽  
Author(s):  
A. Hoppe ◽  
M. Metler ◽  
T. J. Berndt ◽  
F. G. Knox ◽  
S. Angielski
Keyword(s):  
Parathyroid Hormone ◽  
Phosphate Uptake ◽  
Respiratory Alkalosis ◽  
Phosphate Transport ◽  
Phosphate Concentration ◽  
Dibutyryl Camp ◽  
Plasma Phosphate ◽  
Phosphate Reabsorption ◽  
Phosphate Excretion ◽  
Renal Phosphate Excretion

Respiratory alkalosis induced hypophosphatemia and hypophosphaturia in intact animals. The present studies evaluated the effect of respiratory alkalosis on tissue phosphate distribution and renal phosphate transport in the presence and absence of parathyroid hormone (PTH). Respiratory alkalosis decreased plasma phosphate concentration and increased phosphate concentrations in muscle and liver. It decreased fractional phosphate excretion (FEPi) from 6.1 +/- 1.4 to 0.6 +/- 0.2%. In thyroparathyroidectomized (TPTX) rats infused with 20 mM phosphate, respiratory alkalosis decreased FEPi from 15.0 +/- 0.9 to 5.5 +/- 0.1%. PTH or dibutyryl cAMP administration produced a phosphaturia that was blunted by respiratory alkalosis. The phosphaturic response to PTH was also blunted in hypocapnic rats in which alkalosis was prevented by infusion of HCl. We conclude that respiratory alkalosis increases phosphate uptake by muscle, which largely accounts for the hypophosphatemia. The kidney response with increased phosphate reabsorption independent of plasma and kidney phosphate concentrations and with refractoriness to the phosphaturic effect of PTH. This refractoriness to the phosphaturic effect of PTH is due to decreased PCO2 rather than to the concomitant extracellular alkalosis.

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