scholarly journals Comparative Antileukemic Activity of a Tetranorditerpene Isolated from Polyalthia longifolia Leaves and the Derivative against Human Leukemia HL-60 Cells

2017 ◽  
Vol 66 (10) ◽  
pp. 1169-1174 ◽  
Author(s):  
Saheed Afolabi ◽  
Olufunke Olorundare ◽  
Masayuki Ninomiya ◽  
Abiola Babatunde ◽  
Hasan Mukhtar ◽  
...  
Keyword(s):  
Human Leukemia ◽  
Antileukemic Activity ◽  
Polyalthia Longifolia

scholarly journals Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

2013 ◽  
Vol 62 (10) ◽  
pp. 843-848 ◽  
Author(s):  
Dina Permata Sari ◽  
Masayuki Ninomiya ◽  
Mai Efdi ◽  
Adlis Santoni ◽  
Sanusi Ibrahim ◽  
...  
Keyword(s):  
Human Leukemia ◽  
Clerodane Diterpenes ◽  
Polyalthia Longifolia

scholarly journals Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Saheed O. Afolabi ◽  
Olufunke E. Olorundare ◽  
Abiola Babatunde ◽  
Ralph M. Albrecht ◽  
Mamoru Koketsu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Er Stress ◽  
Antioxidant Properties ◽  
Human Leukemia ◽  
Inhibition Of Tumor Growth ◽  
Induced Apoptosis ◽  
Polyalthia Longifolia

Plant-based therapies are being explored to prevent or treat several cancer types. The antioxidant properties of Polyalthia longifolia plant are well established. In our previous work, we demonstrated the presence of cytotoxic compounds in the methanol extract of Polyalthia longifolia (MEP) with potent activity against human leukemia cells. In the present study, we evaluated the efficacy of MEP against prostate cancer (PCa) and established the molecular basis of its effect in in vitro and in vivo models. We observed that MEP treatment resulted in a significant decrease in the growth and viability of PCa cells, associated with arrest in the G1/S phase of the cell cycle. Apoptosis was confirmed as the primary mode of MEP-induced cell death through activation of the intrinsic apoptotic machinery. Proteomic and biochemical studies identified BiP as an important target of MEP with the activation of the ER stress pathway, as a potential mechanism driving MEP-induced apoptosis. The extract exhibited strong efficacy in the PCa xenograft mouse model with significant inhibition of tumor growth and reduced tumor burden. Taken together, our findings indicate that MEP-induced apoptosis in PCa cells concomitant with the activation of the ER stress pathways results in the inhibition of tumor growth, in vitro and in vivo. Our studies provide initial evidence of the efficacy of MEP against PCa and advocate for in-depth studies in other preclinical models for its possible use in clinical settings.

Antileukemic Activity of Selected Natural Products in Taiwan

2003 ◽  
Vol 31 (01) ◽  
pp. 37-46 ◽  
Author(s):  
Lien-Chai Chiang ◽  
Win Chiang ◽  
Mei-Yin Chang ◽  
Lean-Teik Ng ◽  
Chun-Ching Lin
Keyword(s):  
Medicinal Plants ◽  
Cell Lines ◽  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Lymphoma Cell ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Antileukemic Activity ◽  
Lymphoma Cells ◽  
Strong Activity

The aim of the present study was to evaluate the antileukemic activity of six chemical classes of pure compounds present in commonly used medicinal plants in Taiwan – such as the genus Plantago. Studies were conducted on a series of human leukemia and lymphoma cell lines. Results showed that water soluble compounds (aucubin, caffeic acid, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid) exhibited a weak antileukemic activity (IC50: 26–56 μg/ml, SI: 2–11). On the other hand, water insoluble compounds such as triterpenoids (oleanolic acid and ursolic acid), monoterpene (linalool) and flavonoid (luteolin) possessed strong activity against human leukemia and lymphoma cell lines. Among them, linalool showed the strongest activity against histiocytic lymphoma cells U937 (IC50: 3.51 μg/ml, SI: 592.6) and Burkitt lymphoma cells P3HR1 (IC50: 4.21 μg/ml, SI: 494.1). Ursolic acid was effective against P3HR1 cells (IC50: 2.5 μg/ml, SI: 262.6) and chronic myelogenous leukemia cells K562 (IC50: 17.79 μg/ml, SI: 36.91), whereas oleanolic acid inhibited the growth of P3HR1 cells (IC50: 26.74 μg/ml, SI: 11.37). Luteolin exhibited effective activity against K562 cells (IC50: 18.96 μg/ml, SI: 5.14) and P3HR1 cells (IC50: 18.99 μg/ml, SI: 5.13). We conclude that terpenes and flavonoid in commonly used medicinal plants possess strong activity against lymphoma and leukemia cells, especially human lymphoma cells, suggesting the potential use of these compounds for treatment of lymphoma.

In Vitro Anti-proliferative Effects on NB4 Human Leukemia Cells and Physicochemical Screening of Pleurotus sp. (Higher Basidiomycetes) Mycelia from Cuba

2014 ◽  
Vol 16 (3) ◽  
pp. 239-245 ◽  
Author(s):  
Humberto J. Morris ◽  
Edgar Hernandez ◽  
Gabriel Llaurado ◽  
Maria Cristina Tejedor ◽  
Pilar Sancho ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells
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