scholarly journals Effects of Spacer Chain Length of Amino Acid-Based Gemini Surfactants on Wormlike Micelle Formation

2014 ◽  
Vol 63 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Kenichi Sakai ◽  
Kazuyuki Nomura ◽  
Rekha Goswami Shrestha ◽  
Takeshi Endo ◽  
Kazutami Sakamoto ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chain Length ◽  
Gemini Surfactants ◽  
Micelle Formation ◽  
Wormlike Micelle ◽  
Spacer Chain Length

Solvation dynamics and rotational relaxation of coumarin 153 in mixed micelles of Triton X-100 and cationic gemini surfactants: effect of composition and spacer chain length of gemini surfactants

2016 ◽  
Vol 18 (3) ◽  
pp. 1551-1563 ◽  
Author(s):  
Sonu Sonu ◽  
Sunita Kumari ◽  
Subit K. Saha
Keyword(s):  
Chain Length ◽  
Gemini Surfactant ◽  
Mixed Micelles ◽  
Gemini Surfactants ◽  
Rotational Relaxation ◽  
Solvation Dynamics ◽  
Cationic Gemini Surfactants ◽  
Coumarin 153 ◽  
Spacer Chain Length ◽  
Triton X

To demonstrate simultaneously how the solvation dynamics and rotational relaxation in nonionic micelles change with the composition of a gemini surfactant and how this change depends on spacer chain length of gemini surfactants.

scholarly journals Biological and Physico-Chemical Characteristics of Arginine-Rich Peptide Gemini Surfactants with Lysine and Cystine Spacers

2021 ◽  
Vol 22 (7) ◽  
pp. 3299
Author(s):  
Damian Neubauer ◽  
Maciej Jaśkiewicz ◽  
Marta Bauer ◽  
Agata Olejniczak-Kęder ◽  
Emilia Sikorska ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Cationic Surfactants ◽  
Antimicrobial Agents ◽  
Gemini Surfactants ◽  
Antimicrobial Activities ◽  
Critical Aggregation Concentration ◽  
Cytotoxic Activities ◽  
Candida Sp ◽  
Enhanced Selectivity

Ultrashort cationic lipopeptides (USCLs) and gemini cationic surfactants are classes of potent antimicrobials. Our recent study has shown that the branching and shortening of the fatty acids chains with the simultaneous addition of a hydrophobic N-terminal amino acid in USCLs result in compounds with enhanced selectivity. Here, this approach was introduced into arginine-rich gemini cationic surfactants. L-cystine diamide and L-lysine amide linkers were used as spacers. Antimicrobial activity against planktonic and biofilm cultures of ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) strains and Candida sp. as well as hemolytic and cytotoxic activities were examined. Moreover, antimicrobial activity in the presence of human serum and the ability to form micelles were evaluated. Membrane permeabilization study, serum stability assay, and molecular dynamics were performed. Generally, critical aggregation concentration was linearly correlated with hydrophobicity. Gemini surfactants were more active than the parent USCLs, and they turned out to be selective antimicrobial agents with relatively low hemolytic and cytotoxic activities. Geminis with the L-cystine diamide spacer seem to be less cytotoxic than their L-lysine amide counterparts, but they exhibited lower antibiofilm and antimicrobial activities in serum. In some cases, geminis with branched fatty acid chains and N-terminal hydrophobic amino acid resides exhibited enhanced selectivity to pathogens over human cells.

Synthesis, surface adsorption and micelle formation of a class of morpholinium gemini surfactants

2017 ◽  
Vol 54 ◽  
pp. 226-233 ◽  
Author(s):  
Caili Dai ◽  
Sisi Fang ◽  
Mei Hu ◽  
Xiaojuan He ◽  
Mingwei Zhao ◽  
...  
Keyword(s):  
Gemini Surfactants ◽  
Surface Adsorption ◽  
Micelle Formation

Effect of charged amino acid side chain length on lateral cross-strand interactions between carboxylate- and guanidinium-containing residues in a β-hairpin

Amino Acids ◽  
2015 ◽  
Vol 47 (5) ◽  
pp. 885-898 ◽  
Author(s):  
Hsiou-Ting Kuo ◽  
Shing-Lung Liu ◽  
Wen-Chieh Chiu ◽  
Chun-Jen Fang ◽  
Hsien-Chen Chang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chain Length ◽  
Side Chain ◽  
Amino Acid Side Chain ◽  
Side Chain Length

Adsorption and aggregation properties of amino acid-based N-alkyl cysteine monomeric and -dialkyl cystine gemini surfactants

2007 ◽  
Vol 308 (2) ◽  
pp. 466-473 ◽  
Author(s):  
Tomokazu Yoshimura ◽  
Ayako Sakato ◽  
Koji Tsuchiya ◽  
Takahiro Ohkubo ◽  
Hideki Sakai ◽  
...  
Keyword(s):  
Amino Acid ◽  
Gemini Surfactants
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