scholarly journals The Consumption of a Structured Triacylglycerol Containing Behenic and Oleic Acids Increases Fecal Fat Excretion in Humans

2013 ◽  
Vol 62 (12) ◽  
pp. 997-1001 ◽  
Author(s):  
Makiko Kojima ◽  
Toshiharu Arishima ◽  
Ryoma Shimizu ◽  
Mitsutaka Kohno ◽  
Haruyasu Kida ◽  
...  
1967 ◽  
Vol 119 (6) ◽  
pp. 573-576 ◽  
Author(s):  
E. C. Raffensperger
Keyword(s):  

2007 ◽  
Vol 293 (2) ◽  
pp. G510-G516
Author(s):  
Karin E. R. Gooijert ◽  
Rick Havinga ◽  
Alida R. Oosterloo-Duinkerken ◽  
Enge E. A. Venekamp-Hoolsema ◽  
Folkert Kuipers ◽  
...  

Erythropoietic protoporphyria (EPP) is characterized by toxic accumulation of the hydrophobic compound protoporphyrin (PP). Ferrochelatase-deficient ( fch/ fch) mice are an animal model for human EPP. Recently, we have demonstrated that the accumulation of another hydrophobic compound, unconjugated bilirubin, could effectively be treated by stimulation of fecal fat excretion. We investigated whether stimulation of fecal fat excretion enhanced the disposal of PP in fch/ fch mice. Fch/ fch mice were fed for 8 wk with a high-fat diet (16 wt% fat; control) or with the high-fat diet mixed with either a nonabsorbable fat (sucrose polyester) or the intestinal lipase inhibitor orlistat. The effects of the treatments on fecal excretion of fat and PP and on hepatic PP concentrations were compared with control diets. Fecal fat excretion in fch/ fch mice on a high-fat diet was higher than in mice on a low-fat diet (+149%, P < 0.05). Sucrose polyesters and orlistat increased fecal fat excretion even more, up to sixfold of control values. However, none of the different treatments affected fecal PP excretion or hepatic PP concentration. Treatment of fch/ fch mice with a high-fat diet, a nonabsorbable fat diet, or with orlistat increased the fecal excretion of fat but did not increase fecal PP excretion or decrease hepatic PP concentration. The present data indicate that accumulation of PP is not amenable to stimulation of fecal fat excretion.


2014 ◽  
Vol 99 (5) ◽  
pp. 984-991 ◽  
Author(s):  
Karina V Soerensen ◽  
Tanja K Thorning ◽  
Arne Astrup ◽  
Mette Kristensen ◽  
Janne K Lorenzen

2018 ◽  
Vol 3 (3) ◽  
pp. 357-365
Author(s):  
Michael Korostensky ◽  
Steven R Martin ◽  
Mark Swain ◽  
Maitreyi Raman ◽  
Christopher T Naugler ◽  
...  

Abstract Background The 72-h quantitative fecal fat test has been mostly obsolete for many years. Our objective was to reduce and eliminate the use of this test, while providing suitable alternatives. Methods We assessed (2010–2016) utilization of the fecal fat test in Calgary, Central Alberta, and Southern Alberta, Canada. Alternatives were identified through literature review and consultation with gastroenterologist stakeholders. Logistic regression and ROC curves were used to characterize discrimination power of 72-h specimen weight on abnormal fat excretion. This was also examined in 91 subspecimens that were additionally tested for the presence of fat globules. Results As 69% of fecal fat tests (total, 106/year) were on adults (age ≥ 18), stakeholders agreed that adult specimens should not be tested until ordering physicians consulted with a clinical biochemist. This change reduced fecal fat testing by 81% to 20/year in 2015. The 72-h specimen weight was a significant predictor of abnormal fat excretion [P &lt; 0.001; area under curve (AUC) = 0.75–0.79, n = 115–417] in historic fecal fat data. A similar result was observed among subspecimens (AUC = 0.70), which improved when additionally considering the presence of fat globules (AUC = 0.74). Stakeholders consented to replacing fecal fat with a comparison of specimen weight to cutpoints with 80% specificity for abnormal fat excretion, and the test for fat globules. Conclusion Through stakeholder engagement, we implemented changes that eliminated 72-h quantitative fecal fat testing in a large geographic region in Alberta, Canada. Future fecal fat orders would be reflexed to an assessment of 72-h specimen weight and a qualitative test for fat globules in stool.


2014 ◽  
Vol 25 (3) ◽  
pp. 185-190 ◽  
Author(s):  
Ken-ichi Kobayashi ◽  
Yu Matsumoto ◽  
Misato Hirota ◽  
Takahumi Enda ◽  
Akiko Teramoto ◽  
...  
Keyword(s):  

2012 ◽  
Vol 47 (8-9) ◽  
pp. 1120-1121 ◽  
Author(s):  
Arnold Berstad ◽  
Mette Helvik Morken ◽  
Gülen Arslan Lied ◽  
Ragna Lind ◽  
Aud-Sissel Hjartholm ◽  
...  

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