scholarly journals Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson^|^rsquo;s disease mouse model

2013 ◽  
Vol 62 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Hideaki Kabuto ◽  
Tomoko T. Yamanushi ◽  
Najma Janjua ◽  
Fusako Takayama ◽  
Mitsumasa Mankura
Keyword(s):  
Enzyme Activity ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Mouse Model ◽  
Antioxidant Enzyme ◽  
Acid Composition ◽  
Antioxidant Enzyme Activity

scholarly journals Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity

2020 ◽  
Vol 318 (6) ◽  
pp. E995-E1003
Author(s):  
Guillermo García-Eguren ◽  
Aleix Sala-Vila ◽  
Oriol Giró ◽  
Arturo Vega-Beyhart ◽  
Felicia A. Hanzu
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Mouse Model ◽  
Acid Composition ◽  
Visceral Adipose Tissue ◽  
Diet Induced Obesity ◽  
Visceral Adipose ◽  
Composition Changes

Glucocorticoids (GCs) play critical roles in adipose tissue metabolism. Here, we compare in a mouse model the effects of chronic glucocorticoid excess and diet-induced obesity on white adipose tissue mass and distribution, by focusing on visceral adipose tissue (VAT) fatty acid composition changes, the role of de novo lipogenesis (DNL) and the inflammatory state. We used a noninvasive mouse model of hypercortisolism to compare GC-induced effects on adipose tissue with diet-induced obesity [high-fat diet (HFD) 45%] and control mice after 10 wk of treatment. Subcutaneous adipose tissue (SAT) and VAT mass and distribution were measured by nuclear magnetic resonance imaging (NMRI). Fatty acid composition in VAT was analyzed by NMR spectroscopy and gas chromatography. Gene expression of key enzymes involved in DNL was analyzed in liver and VAT. Macrophage infiltration markers and proinflammatory cytokines were measured by gene expression in VAT. HFD or GC treatment induced similar fat mass expansion with comparable distribution between SAT and VAT depots. However, in VAT, GCs induce DNL, higher palmitic acid (PA), macrophage infiltration, and proinflammatory cytokine levels, accompanied by systemic nonesterified fatty acid (NEFA) elevation, hyperinsulinemia, and higher homeostatic model assessment for insulin resistance (HOMA-IR) levels compared with diet-induced obesity. Thus, chronic hypercortisolism induces DNL and fatty acid composition changes toward increased SFA and reduced polyunsaturated fatty acid (PUFA) levels in VAT, promoting macrophage recruitment and proinflammatory cytokines, suggesting a worse cardiometabolic profile even compared with HFD mice.

scholarly journals Pulicaria gnaphalodes powder in broiler diets: consequences for performance, gut health, antioxidant enzyme activity, and fatty acid profile

2019 ◽  
Vol 98 (6) ◽  
pp. 2577-2587 ◽  
Author(s):  
V. Shirani ◽  
V. Jazi ◽  
M. Toghyani ◽  
A. Ashayerizadeh ◽  
F. Sharifi ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Fatty Acid ◽  
Antioxidant Enzyme ◽  
Fatty Acid Profile ◽  
Antioxidant Enzyme Activity ◽  
Gut Health

scholarly journals Bisphenol A Alters n-6 Fatty Acid Composition and Decreases Antioxidant Enzyme Levels in Rat Testes: A LC-QTOF-Based Metabolomics Study

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44754 ◽  
Author(s):  
Minjian Chen ◽  
Bin Xu ◽  
Wenliang Ji ◽  
Shanlei Qiao ◽  
Nan Hu ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Bisphenol A ◽  
Antioxidant Enzyme ◽  
Acid Composition ◽  
Metabolomics Study
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