scholarly journals Effect of Dietary Alpha-Linolenic Acid on Vascular Reactivity in Aorta of Spontaneously Hypertensive Rats

2009 ◽  
Vol 58 (5) ◽  
pp. 221-225 ◽  
Author(s):  
Akiko Ogawa ◽  
Yo Suzuki ◽  
Toshiaki Aoyama ◽  
Hiroyuki Takeuchi
Keyword(s):  
Linolenic Acid ◽  
Spontaneously Hypertensive Rats ◽  
Vascular Reactivity ◽  
Hypertensive Rats ◽  
Alpha Linolenic Acid ◽  
Spontaneously Hypertensive

Effects of high-cholesterol and atherogenic diets on vascular relaxation in spontaneously hypertensive rats

1997 ◽  
Vol 273 (2) ◽  
pp. H647-H654 ◽  
Author(s):  
M. Cappelli-Bigazzi ◽  
S. Rubattu ◽  
C. Battaglia ◽  
R. Russo ◽  
I. Enea ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Function ◽  
Spontaneously Hypertensive Rats ◽  
Vascular Reactivity ◽  
Male Rats ◽  
Standard Diet ◽  
High Cholesterol ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Endothelium Dependent Relaxation

Hypercholesterolemia is associated with more rapid development of atherosclerosis, and hypertension is frequently associated with abnormal vascular function. Therefore, to investigate the role of hypercholesterolemia and hypertension on vascular function, we studied three groups of male rats (aged 6 wk): normotensive Wistar-Kyoto rats (WKY) as a control group and spontaneously hypertensive rats (SHR) receiving either standard diet (SD; SHR-SD) or high-cholesterol (1%) diet (ChD; SHR-ChD). Vascular reactivity was tested on isolated aortic rings at 4 wk and at 3 and 6 mo of diet. At 3 mo, endothelium-dependent relaxation to acetylcholine (ACh) and ADP was significantly reduced in SHR-ChD but not in SHR-SD compared with WKY. At 6 mo, relaxations to ACh were further impaired in both SHR groups compared with WKY. Endothelium-independent vasodilation to nitroglycerin (NTG) was not different in the three groups of animals throughout 6 mo of diet. In additional experiments, we evaluated vascular reactivity in rats fed with ChD enriched with an excess of vitamin D [atherogenic diet (AD)] capable of producing vascular atherosclerotic lesions. In particular, we studied three additional groups of WKY and SHR rats fed with SD, AD, or AD plus a nonhypotensive dose of the calcium antagonist nitrendipine (Nit). Vasodilation to ACh and ADP was significantly blunted in WKY-AD compared with WKY-SD, whereas it was partially improved in WKY-Nit. There were no differences in endothelium-independent relaxation to NTG in the three WKY groups. In contrast, SHR-AD showed a marked reduction of endothelium-dependent and -independent vasodilation, but only endothelium-dependent vasodilation was preserved by addition of Nit to the diet. These data suggest that the development of vascular dysfunction in rat genetic hypertension is accelerated by ChD, in absence of detectable vascular lesions. Our study also shows that AD alters both vascular smooth muscle and endothelium-dependent relaxation. Low doses of Nit partially preserve endothelium-dependent vasodilation but do not affect the impairment of smooth muscle function in these rats.

Bile acids are able to reduce blood pressure by attenuating the vascular reactivity in spontaneously hypertensive rats

Life Sciences ◽  
1988 ◽  
Vol 42 (19) ◽  
pp. 1861-1868 ◽  
Author(s):  
Takehiko Tominaga ◽  
Hiromichi Suzuki ◽  
Yasuhide Ogata ◽  
Toshio Imafuku ◽  
Takao Saruta
Keyword(s):  
Blood Pressure ◽  
Bile Acids ◽  
Spontaneously Hypertensive Rats ◽  
Vascular Reactivity ◽  
Reduce Blood Pressure ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

COMPARATIVE EFFECTS OF TRAMADOL ON VASCULAR REACTIVITY IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

2008 ◽  
Vol 35 (10) ◽  
pp. 1197-1203 ◽  
Author(s):  
Juliana M Raimundo ◽  
Luana B Pontes ◽  
Fernanda Antunes ◽  
Roberto T Sudo ◽  
Margarete M Trachez ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Vascular Reactivity ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Renal Vascular Reactivity to P2-Purinoceptor Activation in Spontaneously Hypertensive Rats

Pharmacology ◽  
2000 ◽  
Vol 60 (1) ◽  
pp. 47-50 ◽  
Author(s):  
Oscar Fernández ◽  
Rosemary Wangensteen ◽  
Antonio Osuna ◽  
Félix Vargas
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Vascular Reactivity ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Renal Vascular
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