scholarly journals Relative Susceptibilities of Linoleates and Cholesterol to Oxidation Assessed by Total Hydroxyoctadecadienoic Acid and 7-Hydroxycholesterol

2008 ◽  
Vol 57 (7) ◽  
pp. 407-414 ◽  
Author(s):  
Yasukazu Yoshida ◽  
Etsuo Niki
Keyword(s):  
Hydroxyoctadecadienoic Acid

scholarly journals Linoleic acid-derived 13-hydroxyoctadecadienoic acid is absorbed and incorporated into rat tissues

2020 ◽  
pp. 158870
Author(s):  
Zhichao Zhang ◽  
Shiva Emami ◽  
Marie Hennebelle ◽  
Rhianna K. Morgan ◽  
Larry A. Lerno ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Rat Tissues ◽  
Hydroxyoctadecadienoic Acid

Dynamics of hydroxyoctadecadienoic acid in epilepsy patients treated with valproic acid

2015 ◽  
Vol 58 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Kohji Azumagawa ◽  
Makoto Mino ◽  
Noriko Ishida ◽  
Mototada Shichiri ◽  
Yasushi Shigeri ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Hydroxyoctadecadienoic Acid

scholarly journals Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis

2019 ◽  
Vol 20 (17) ◽  
pp. 4249 ◽  
Author(s):  
Piotr Wójcik ◽  
Michał Biernacki ◽  
Adam Wroński ◽  
Wojciech Łuczaj ◽  
Georg Waeg ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Psoriatic Arthritis ◽  
Stress Responses ◽  
Psoriasis Vulgaris ◽  
Mononuclear Cells ◽  
Leukotriene B4 ◽  
Cyclooxygenase 1 ◽  
Hydroxyoctadecadienoic Acid ◽  
Altered Lipid ◽  
Cox 1

The aim of this study was to investigate possible stress-associated disturbances in lipid metabolism in mononuclear cells, mainly lymphocytes of patients with psoriasis vulgaris (Ps, n = 32) or with psoriatic arthritis (PsA, n = 16) in respect to the healthy volunteers (n = 16). The results showed disturbances in lipid metabolism of psoriatic patients reflected by different phospholipid profiles. The levels of non-enzymatic lipid metabolites associated with oxidative stress 8-isoprostaglandin F2α (8-isoPGF2α) and free 4-hydroxynonenal (4-HNE) were higher in PsA, although levels of 4-HNE-His adducts were higher in Ps. In the case of the enzymatic metabolism of lipids, enhanced levels of endocannabinoids were observed in both forms of psoriasis, while higher expression of their receptors and activities of phospholipases were detected only in Ps. Moreover, cyclooxygenase-1 (COX-1) activity was enhanced only in Ps, but cyclooxygenase-2 (COX-2) was enhanced both in Ps and PsA, generating higher levels of eicosanoids: prostaglandin E1 (PGE1), leukotriene B4 (LTB4), 13-hydroxyoctadecadienoic acid (13HODE), thromboxane B2 (TXB2). Surprisingly, some of major eicosanoids 15-d-PGJ2 (15-deoxy-Δ12,14-prostaglandin J2), 15-hydroxyeicosatetraenoic acid (15-HETE) were elevated in Ps and reduced in PsA. The results of our study revealed changes in lipid metabolism with enhancement of immune system-modulating mediators in psoriatic mononuclear cells. Evaluating further differential stress responses in Ps and PsA affecting lipid metabolism and immunity might be useful to improve the prevention and therapeutic treatments of psoriasis.

IS THE ENDOTHELIAL EXTRACELLULAR MATRIX THROMBOGENIC OR THROMBORESISTANT? EFFECT OF PREPARATION AND 13-HODE LEVELS

1987 ◽  
Author(s):  
M R Buchanan ◽  
E Bastida ◽  
J Aznar-Salatti ◽  
P de Groot
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cell ◽  
Cellulose Acetate ◽  
Surface Area ◽  
Whole Blood ◽  
Hplc Analysis ◽  
Platelet Adhesion ◽  
Flow Conditions ◽  
Hydroxyoctadecadienoic Acid ◽  
Static Conditions

It is generally thought that the extracellular matrix (ECM) is thrombogenic.However,one of us (MRB) has reported that the ECM is thromboresistant,and postulated that this was due to the release of endothelial cell (EC) 13-hydroxyoctadecadienoic acid (13-HODE) into the ECM. To test this possibility, we measured platelet adhesion (PLT ADH) onto cultured ECs and their ECMs exposed by 3 methods. We also extracted the ECMs for HPLC analysis of 13-HODE.PLT ADH was expressed as i)adhesion of 3H-adenine labelled platelets/mm2 of ECs or ECMs under static conditions, and ii) % surface^ area coverage measured morphometrically following 5"perfusion with citrated whole blood at 1300 sec-1 in the flat chamber.ECMs were prepared by removing the EC monolayers by freeze thawing , cellulose acetate stripping or NH4OH treatment. PLT ADH to ECs under static and flow conditions were 4700±240/mm2 and 0.1%, respectively, and were associated with 12,6± 1 pg of 13-HODE/mm2 of EC surface (M+SEM). Removal of the ECs by freeze thawing or stripping, resulted in a 18% and 25% increase in PLT ADH to the ECM,under static and flow conditions respectively, and a 80% decrease in ECM associated 13-HODE level. Removal of the EC by NH4OH resulted in a 380% and 770% increase in PLT ADH to the ECM in static and flow conditions. 13-HODE was undetectable.These data support the hypothesis that 13-HODE released from ECs influences the ECM thrombogenecity, and indicate that the residual amounts of components present in the ECMs following EC removal is influenced by the method of ECM preparation.

scholarly journals G2A Plays Proinflammatory Roles in Human Keratinocytes under Oxidative Stress as a Receptor for 9-Hydroxyoctadecadienoic Acid

2008 ◽  
Vol 128 (5) ◽  
pp. 1123-1133 ◽  
Author(s):  
Tomoyasu Hattori ◽  
Hideru Obinata ◽  
Ai Ogawa ◽  
Mikiko Kishi ◽  
Kazuaki Tatei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Keratinocytes ◽  
Hydroxyoctadecadienoic Acid
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