scholarly journals Modulation of Cutaneous Fatty Acid-binding Protein mRNA Expression in Rat Adipose Tissues by Hereditary Obesity and Dietary Fats

2007 ◽  
Vol 56 (10) ◽  
pp. 533-541 ◽  
Author(s):  
Masayo Kushiro ◽  
Yoko Takahashi ◽  
Takashi Ide
Keyword(s):  
Fatty Acid ◽  
Mrna Expression ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Dietary Fats ◽  
Adipose Tissues ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Hereditary Obesity

Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease

2012 ◽  
Vol 302 (6) ◽  
pp. H1231-H1240 ◽  
Author(s):  
Aimin Xu ◽  
Paul M. Vanhoutte
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acid ◽  
Blood Vessels ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Biologically Active ◽  
Adipose Tissues ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Obesity And Diabetes

The heart and blood vessels are surrounded by epicardial and perivascular adipose tissues, respectively, which play important roles in maintaining cardiovascular homeostasis by secreting a number of biologically active molecules, termed “adipokines.” Many of these adipokines function as an important component of the ‘adipo-cardiovascular axis’ mediating the cross talk between adipose tissues, the heart, and the vasculature. On the one hand, most adipokines [including tumor necrosis factor-α, resistin, adipocyte fatty acid binding protein (A-FABP), and lipocalin-2] are proinflammatory and causally associated with endothelial and cardiac dysfunction by their endocrine/paracrine actions. On the other hand, adiponectin is one of the few adipokines that possesses multiple salutary effects on the prevention of cardiovascular disease, because of its pleiotropic actions on the heart and the blood vessels. The discordant production of adipokines in dysfunctional adipose tissue is a key contributor to obesity-related cardiovascular disease. This review provides an update in understanding the roles of adipokines in the pathogenesis of cardiovascular disorders associated with obesity and diabetes and focuses on the two most abundant adipokines, adiponectin and A-FABP. Indeed, data from both animal studies and clinical investigations imply that these two adipokines are prognostic biomarkers for cardiovascular disease and even promising therapeutic targets for its treatment.

scholarly journals Cardiac Surgery Increases Serum Concentrations of Adipocyte Fatty Acid-Binding Protein and Its mRNA Expression in Circulating Monocytes but Not in Adipose Tissue

2014 ◽  
pp. 83-94 ◽  
Author(s):  
T. KOTULAK ◽  
J. DRAPALOVA ◽  
M. LIPS ◽  
Z. LACINOVA ◽  
P. KRAMAR ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Cardiac Surgery ◽  
Fatty Acid ◽  
Mrna Expression ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Serum Concentrations ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Adipocyte fatty acid binding protein (A-FABP) is a novel adipokine involved in the regulation of lipid and glucose metabolism and inflammation. To evaluate its potential role in the development of postoperative hyperglycemia and insulin resistance we assessed A-FABP serum concentrations and mRNA expression in skeletal and myocardial muscle, subcutaneous and epicardial adipose tissue and peripheral monocytes in 11 diabetic and 20 age- and sex-matched non-diabetic patients undergoing elective cardiac surgery. Baseline serum A-FABP did not differ between the groups (31.1±5.1 vs. 25.9±4.6 ng/ml, p=0.175). Cardiac surgery markedly increased serum A-FABP in both groups with a rapid peak at the end of surgery followed by a gradual decrease to baseline values during the next 48 h with no significant difference between the groups at any timepoint. These trends were analogous to postoperative excursions of plasma glucose, insulin and selected proinflammatory markers. Cardiac surgery increased A-FABP mRNA expression in peripheral monocytes, while no effect was observed in adipose tissue or muscle. Our data suggest that circulating A-FABP might be involved in the development of acute perioperative stress response, insulin resistance and hyperglycemia of critically ill irrespectively of the presence of diabetes mellitus.

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