scholarly journals Solubility Estimation for Drugs Treated with the Simple Suspension Method Using Available Dissolution Test Profiles

2015 ◽  
Vol 41 (8) ◽  
pp. 540-549
Author(s):  
Wataru Sakurada ◽  
Tetsuya Shimoyama ◽  
Kunihiko Itoh ◽  
Michiya Kobayashi
Keyword(s):  
Dissolution Test ◽  
Solubility Estimation ◽  
Test Profiles

The Use of the Defense Mechanism Test to Aid in Understanding the Personality of Senior Executives and the Implications for Their Careers

2009 ◽  
Vol 30 (1) ◽  
pp. 73-96 ◽  
Author(s):  
Olya Khaleelee
Keyword(s):  
Crisis Intervention ◽  
Defense Mechanisms ◽  
Defense Mechanism ◽  
Senior Executives ◽  
Ideal Types ◽  
The Individual ◽  
Test Profiles ◽  
Real Test

This paper describes the use of the Defense Mechanism Test as an aid in helping to assess senior executives in four areas: for selection, development, career strategy, and crisis intervention. The origins of this test, developed to measure the defense mechanisms used to protect the individual from stress, are described. The paper shows how it was used to predict the capacity of trainee fighter pilots to withstand stress and its later application to other stressful occupations. Finally, some ideal types of the test are shown followed by four real test profiles, two of them with their associated histories.

Preparation of Calcium Phosphate Glasses Containing Nb2O5 and TiO2

2018 ◽  
Vol 782 ◽  
pp. 47-52
Author(s):  
Patrícia Suemi Sato ◽  
Hirotaka Maeda ◽  
Akiko Obata ◽  
Toshihiro Kasuga
Keyword(s):  
Controlled Release ◽  
Calcium Phosphate ◽  
Calcium Titanate ◽  
Chemical Durability ◽  
Phosphate Glasses ◽  
Dissolution Test ◽  
Buffer Solution ◽  
High Chemical ◽  
Positive Effects ◽  
Tris Buffer Solution

60CaO-30P2O5-(10 ̶ x)Nb2O5-xTiO2 (x = 0 ~ 10, mol%) glasses were prepared in order to obtain biomaterials with high chemical durability and therapeutic ions releasability. Dissolution test of these glasses using Tris buffer solution showed the controlled release of niobate ions from Nb2O5-containing glasses and the formation of calcium titanate in some of them. These behavior might induce positive effects for bone regeneration.

Effects of Vessel Geometric Irregularity on Dissolution Test Results

2011 ◽  
Vol 100 (3) ◽  
pp. 1093-1101 ◽  
Author(s):  
Zongming Gao ◽  
Shafiq Ahadi ◽  
Terry W. Moore ◽  
William H. Doub ◽  
B.J. Westenberger ◽  
...  
Keyword(s):  
Dissolution Test ◽  
Test Results

scholarly journals Developing methods to compare tablet formulations of atorvastatin

2012 ◽  
Vol 48 (4) ◽  
pp. 801-810 ◽  
Author(s):  
Marcelo Antonio de Oliveira ◽  
Caroline Dutra Lacerda ◽  
André Fazôlo Bonella
Keyword(s):  
Rotation Speed ◽  
Pharmaceutical Formulations ◽  
Generic Product ◽  
Dissolution Test ◽  
Dissolution Medium ◽  
Differential Dissolution ◽  
Tablet Formulations ◽  
Biopharmaceutical Classification System ◽  
Paddle Apparatus ◽  
The Ideal

Atorvastatin (ATV) is an antilipemic drug of great interest to the pharmaceutical industry. ATV does not appear in the monographs of Brazilian pharmacopoeia, and analytical methodologies for its determination have been validated. The chromatographic conditions used included: RP-18 column-octadecylsilane (250 x 4.6 mm, 5 mm), detection at 238 nm, mobile phase containing 0.1% phosphoric acid and acetonitrile (35:65% v/v), flow at 1.5 mL min-1, oven temperature at 30ºC, and injection volume of 10 mL. ATV is classified as a class II product, according to the biopharmaceutical classification system. As such, a dissolution test was proposed to evaluate pharmaceutical formulations on the market today, under the following conditions: water as a dissolution medium, 1000 mL as a volume, paddle apparatus at a rotation speed of 50 rpm, 80% (Q) in 15 minutes with UV spectrophotometer readings at 238 nm. In the pattern condition proposed as the ideal dissolution test, which appropriately differentiates amongst formulations, the generic product was not considered pharmaceutically equivalent; however, in other less differential dissolution methods, which also fall within appropriate legal parameters, this product could come to be regarded as generic.

scholarly journals Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry

Química Nova ◽  
2010 ◽  
Vol 33 (2) ◽  
pp. 377-383 ◽  
Author(s):  
Rudy Bonfilio ◽  
Taciane Ferreira Mendonça ◽  
Gislaine Ribeiro Pereira ◽  
Magali Benjamim de Araújo ◽  
César Ricardo Teixeira Tarley
Keyword(s):  
Drug Release ◽  
Losartan Potassium ◽  
Uv Spectrophotometry ◽  
Dissolution Test
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