scholarly journals Study on Adverse Effects of Methotrexate in Patients with Rheumatoid Arthritis (RA) and Efficacy of Folic Acid Supplementation in Reducing Toxicity of Methotrexate

2004 ◽  
Vol 30 (11) ◽  
pp. 705-712
Author(s):  
Yoko Ninomiya ◽  
Keiko Iwashita ◽  
Eiko Uchida ◽  
Keiko Hara ◽  
Masahiro Uchida
Keyword(s):  
Rheumatoid Arthritis ◽  
Folic Acid ◽  
Adverse Effects ◽  
Folic Acid Supplementation ◽  
Acid Supplementation

scholarly journals The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis

1990 ◽  
Vol 33 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Sarah L. Morgan ◽  
Joseph E. Baggott ◽  
William H. Vaughn ◽  
Peggy K. Young ◽  
Janet V. Austin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Folic Acid ◽  
Low Dose ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Dose Methotrexate

scholarly journals Effect of Folic Acid Supplementation for Reducing Methotrexate Side Effects in Patients with Rheumatoid Arthritis: an Evidence-based Case Report

2021 ◽  
Vol 12 (2) ◽  
pp. 274-278
Author(s):  
Athira Presialia ◽  
Bambang Setyohadi
Keyword(s):  
Rheumatoid Arthritis ◽  
Folic Acid ◽  
Side Effects ◽  
Liver Toxicity ◽  
Statistical Significance ◽  
Signs And Symptoms ◽  
Folic Acid Supplementation ◽  
Joint Disease ◽  
Acid Supplementation ◽  
Gastrointestinal Side Effects

Background: Rheumatoid arthritis is a chronic inflammatory joint disease,indicated by a symmetrical erosive synovitis. Disease-modifying anti-rheumaticdrugs (DMARDs) are known to interfere with signs and symptoms of RA, improvephysical function and therefore increase patient productivity. Methotrexate is ananchor drug for rheumatoid arthritis patients, however, its related mechanism ofaction with folate deficiency resulting in some side effects, includinggastrointestinal and liver toxicity. Folic acid supplementation may reduce theseside effects. Method: A search was conducted on Pubmed, Cochrane, EBSCOhost,and ProQuest. After the selection of title and abstract was done using inclusionand exclusion criteria, which led to one relevant article. The selected study wascritically appraised for its validity, importance, and applicability. Result: Inrheumatoid arthritis patient receiving methotrexate, there was a statisticallysignificant reduction in the incidence of abnormal transaminase elevation (RR:0.19, 95% CI: 0.10-0.36), but the reduction in gastrointestinal side effects did notreach statistical significance (RR: 0.76, 95% CI: 0.57-1.01) Conclusion: Folic acidsupplementation has an effect in reducing gastrointestinal and liver toxicity as sideeffects of methotrexate in rheumatoid arthritis patients.

Usefulness of daily folic acid supplementation during methotrexate treatment of Japanese patients with rheumatoid arthritis

2020 ◽  
Vol 31 (1) ◽  
pp. 108-113
Author(s):  
Keiichi Sasaki ◽  
Toshikazu Tsuji ◽  
Yasutaka Kimoto ◽  
Yuki Yanagihara ◽  
Ken Masuguchi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Folic Acid ◽  
Japanese Patients ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Methotrexate Treatment
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