Determining NOEL/NOAEL in Repeated-dose Toxicity Studies, When the Low Dose Group Shows Significant Difference in Quantitative Data

2010 ◽  
Vol 26 (2) ◽  
pp. 133 ◽  
Author(s):  
Katsumi Kobayashi ◽  
K. Sadasivan Pillai ◽  
Mathews Michael ◽  
K.M. Cherian ◽  
Mariko Ohnishi
Keyword(s):  
Quantitative Data ◽  
Dose Group ◽  
Low Dose ◽  
Repeated Dose ◽  
Toxicity Studies ◽  
Repeated Dose Toxicity ◽  
Significant Difference

Oral Repeated-dose Toxicity Studies Especially in the Liver and Kidney of Rats Administered with Organic Germanium-fortified Yeasts

2006 ◽  
Vol 11 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Sung-Hee Lee ◽  
Kyeong-Nam Oh ◽  
Sook-Nyung Rho ◽  
Bok-Hee Lee ◽  
Hyun-Joo Lee
Keyword(s):  
Repeated Dose ◽  
Toxicity Studies ◽  
Repeated Dose Toxicity ◽  
Liver And Kidney

Comparative Analysis on Low- and Standard-Dose Regimes of Alteplase Thrombolytic Therapy for Acute Ischemic Stroke: Efficacy and Safety

2017 ◽  
Vol 79 (1-2) ◽  
pp. 68-73 ◽  
Author(s):  
Guangjian Zhao ◽  
Tingfen Huang ◽  
Mei Zheng ◽  
Yansen Cui ◽  
Yunyong Liu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Acute Ischemic Stroke ◽  
Dose Group ◽  
Low Dose ◽  
Standard Dose ◽  
Efficacy And Safety ◽  
Significant Difference ◽  
Symptomatic Intracranial Hemorrhage ◽  
Intravenous Alteplase

Objective: This study analyzed the efficacy and safety of low-dose and standard-dose alteplase intravenous thrombolytic therapy for acute ischemic stroke (AIS). Methods: Patients with AIS who underwent intravenous alteplase thrombolysis from July 2012 to December 2016 were retrospectively analyzed and correspondingly divided into low-dose (0.6–0.89 mg/kg) group and standard-dose group (0.9 mg/kg) according to alteplase dosage. The clinical outcome was evaluated by modified Rankin Scale (mRS) at 90 days after onset. The safety index was the mortality at 90 days after onset and the incidence of symptomatic intracranial hemorrhage (SICH) within 7 days. Results: A total of 1,486 patients were included (1,115 cases in low-dose group and 371 cases in standard-dose group). There were no significant differences in baseline data between the 2 groups. As mRS, good outcome rate as well as mortality rate in both groups had no significant difference (36.1 vs. 37.6%; χ2 = 10.882, p = 0.890; 5.5 vs. 7.3%; χ2 = 2.163, p = 0.076), but the incidence of SICH in low-dose group was significantly lower than that of the standard-dose group (2.2 vs. 5.9%; χ2 = 3.157, p = 0.001). Conclusion: The efficacy of low-dose alteplase intravenous thrombolytic therapy for AIS was equivalent to the standard-dose regimen but with higher safety.

scholarly journals A clinical comparison of high dose and low dose of Suxamethonium

2014 ◽  
Vol 9 (2) ◽  
pp. 1-8
Author(s):  
RK Yadav ◽  
PC Majhi ◽  
D Tiwari
Keyword(s):  
Intraocular Pressure ◽  
Dose Group ◽  
Low Dose ◽  
Cardiovascular Responses ◽  
High Dose ◽  
Clinical Effects ◽  
Duration Of Action ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Background: Suxamethonium having its rapid onset and short duration of action makes this drug unique amongst the neuromuscular blocking drugs described so far. However, use of suxamethonium is associated with a large number of undesirable side effects. Objective: To evaluate clinical effects of high and low dose of suxamethonium and to determine whether lower dose of suxamethonium can be used for any beneficial effects in terms of its various adverse effects e.g. cardiovascular responses, post-operative muscle pains and intraocular pressure. Methods: A total of 100 patients were included in this prospective study. All these patients on preoperative clinical evaluation were assessed to have adequate airway. All the patients were divided in two groups, low dose group (group I) and High dose group (group II) with 50 patients in each at random. A standard anesthetic technique was adhered to all the patients and following parameters were observed on comparative basis: a. Fasciculation and post operative myalgia. b. Cardiovascular effects, c. Intraocular pressure. Observation: The incidence of post Suxamethonium pain was significantly greater in group II. Increase in heart rate from baseline was significant in both groups. There was no significant difference between the two groups in the diastolic pressure but rise in systolic blood pressure was significant at all assessment times in both groups. This rise from control was statistically significant. Conclusion: Suxamethonium can be used in lower doses (0.5 mg/kg) in elective cases without airway compromise. It gives benefits of reduced muscle pains, cardiovascular responses and intraocular hypertension. Journal of College of Medical Sciences-Nepal, 2013, Vol-9, No-2, 1-8 DOI: http://dx.doi.org/10.3126/jcmsn.v9i2.9677

scholarly journals Oral repeated-dose toxicity studies of BIA 10–2474 in Wistar rat

2020 ◽  
Vol 111 ◽  
pp. 104540 ◽  
Author(s):  
A. Wallace Hayes ◽  
Jerry F. Hardisty ◽  
Stephen B. Harris ◽  
Yoshimasa Okazaki ◽  
Klaus Weber
Keyword(s):  
Wistar Rat ◽  
Repeated Dose ◽  
Toxicity Studies ◽  
Repeated Dose Toxicity

Acute and repeated dose toxicity studies of recombinant saxatilin, a disintegrin from the Korean snake (Gloydius saxatilis)

Toxicon ◽  
2008 ◽  
Vol 51 (3) ◽  
pp. 406-417 ◽  
Author(s):  
Young-Doug Sohn ◽  
Sung-Yu Hong ◽  
Kil-Sang Cho ◽  
Won-Seok Choi ◽  
Si-Whan Song ◽  
...  
Keyword(s):  
Repeated Dose ◽  
Toxicity Studies ◽  
Repeated Dose Toxicity

scholarly journals INTRAVENOUS SINGLE AND REPEATED DOSE TOXICITY STUDIES OF CIMADRONATE (YM175), A NOVEL BISPHOSPHONATE, IN RATS

1995 ◽  
Vol 20 (SupplementI) ◽  
pp. 15-26 ◽  
Author(s):  
Atsushi OKAZAKI ◽  
Hiroko SAKAI ◽  
Toshiaki MATSUZAWA ◽  
Chris J. PERKIN ◽  
Philip W. EAST
Keyword(s):  
Repeated Dose ◽  
Toxicity Studies ◽  
Repeated Dose Toxicity

Neurobehavioural and repeated-dose toxicity studies on the extractive from the decoction of a mixture of Alstonia boonei and Picralima nitida in mice

2019 ◽  
Vol 29 (2) ◽  
pp. 375-383
Author(s):  
Clement O. Ajayi ◽  
Anthony A. Elujoba ◽  
Awodayo O. Adepiti ◽  
Ronald A. Bejide ◽  
Oluwole I. Adeyemi
Keyword(s):  
Repeated Dose ◽  
Toxicity Studies ◽  
Repeated Dose Toxicity
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