scholarly journals Using the Initial Systolic Time Interval to assess cardiac autonomic nervous function in Parkinson’s disease

2019 ◽  
Vol 2 (1) ◽  
pp. 98-101
Author(s):  
Jan H. Meijer ◽  
Eskeline Elbertse ◽  
Sanne Boesveldt ◽  
Henk W. Berendse ◽  
Rudolph M. Verdaasdonk
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Control Function ◽  
Regulatory Control ◽  
Mechanical Activity ◽  
Time Interval ◽  
Systolic Time Interval ◽  
Nervous Control ◽  
Autonomic Nervous ◽  
Systolic Time

Abstract The Initial Systolic Time Interval (ISTI) has been defined as the time difference between the peak electrical and peak mechanical activity of the heart. ISTI is obtained from the electro-cardiogram and the impedance cardiogram. The response of ISTI while breathing at rest and to a deep breathing stimulus was studied in a group of patients suffering from Parkinson’s disease (PD) and a group of healthy control subjects. ISTI showed substantial variability during these manoeuvres. The tests showed that the variability of RR and ISTI was substantially different between PD patients and controls. It is hypothesized that in PD patients the sympathetic nervous system compensates for the loss of regulatory control function of the blood-pressure by the parasympathetic system. It is concluded that ISTI is a practical, additional and independent parameter that can be used to assist other tests in evaluating autonomic nervous control of the heart in PD patients.

scholarly journals Assessing cardiac preload by the Initial Systolic Time Interval obtained from impedance cardiography

2019 ◽  
Vol 1 (1) ◽  
pp. 80-83 ◽  
Author(s):  
Jan H. Meijer ◽  
Annemieke Smorenberg ◽  
Erik J. Lust ◽  
Rudolf M. Verdaasdonk ◽  
A. B. Johan Groeneveld
Keyword(s):  
Inverse Relationship ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Pulse Transit Time ◽  
Clinical Parameter ◽  
Fluid Administration ◽  
Mechanical Activity ◽  
Time Interval ◽  
Systolic Time Interval ◽  
Systolic Time

Abstract The Initial Systolic Time Interval (ISTI), obtained from the electrocardiogram (ECG) and impedance cardiogram (ICG), is considered to be a measure for the time delay between the electrical and mechanical activity of the heart and reflects an early active period of the cardiac cycle. The clinical relevance of this time interval is subject of study. This paper introduces a method using ISTI to evaluate and predict the circulatory response to fluid administration in patients after coronary artery bypass graft surgery and presents preliminary results of a pilot study by comparing ISTI with cardiac output (CO) responsiveness. Also the use of the pulse transit time (PTT), earlier recommended for this purpose, was investigated. The results showed an inverse relationship between ISTI and CO at all moments of fluid administration and also an inverse relationship between the changes ΔISTI and ΔCO before and after full fluid administration. No relationships between PTT and CO or ΔPTT and ΔCO were found. It is concluded that ISTI is dependent upon preload, and that ISTI has the potential to be used as a clinical parameter assessing preload.

scholarly journals Systolic Time Interval (STI) in Hypothyroid Patients Receiving High Dose L-Thyroxine

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Nurul Aulia Zakaria ◽  
Hafizah Pasi ◽  
Mohammad Arif Shahar
Keyword(s):  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Lv Function ◽  
High Dose ◽  
Time Interval ◽  
Ejection Time ◽  
Systolic Time Interval ◽  
Systolic Time ◽  
Ventricular Ejection Time ◽  
Significant Increment

Introduction: Systolic Time Interval (STI) is a simple,noninvasive and precise technique to assess left ventricular (LV) function. It measures aortic Pre-Ejection Period (PEP) over Left Ventricular Ejection Time (LVET) from echocardiogram. Thyrotoxicosis will enhance LV function and cause reduction of STI.  This study was perform to measure the changes of STI after administration of high dose L-thyroxine and to determine the correlation between high dose L-thyroxine administration and STI. Materials and Method: A Total of 22 patients were screened. Those with cardiac diseases and high Framingham risk score were excluded. Nine patients were started on high dose L-thyroxine (7x their usual dose) once a week during the month of Ramadan.Thyroid hormones ( T3,T4,TSH)  and STI (PEP/LVET) were measured at baseline and within 24 hrs after high dose L-thyroxine ingestion. Results: All patients have normal thyroid hormones level and normal cardiac function at baseline. The median dose (mcg) of L-thyroxine was 600 (437.5,700) while the median level of fT4 (pmol/L) was 17.43(12.38,20.8). Despite the significant increment of fT4 after Lthyroxine ingestion [baseline 13.21(8.19,14.63) vs high dose 17.43(12.38,22.55) p; 0.011] there was no significant change in STI [baseline 0.3(0.2,0.4) vs high dose 0.28(0.26,0.45) p; 0.513]. There was no correlation found between the dose of Lthyroxine and STI (r=0.244 , p;0.526).  Conclusion: Administration of high dose Lthyroxine did not significantly alter STI despite significant increment of fT4 level unlike the naturally occurring thyrotoxicosis.Therefore ‘exogenous’ administration of high dose L-thyroxine is cardiac safe.

Utility of M-Mode Echocardiography for Early Identification of Infants with Persistent Pulmonary Hypertension of the Newborn

PEDIATRICS ◽  
1981 ◽  
Vol 68 (4) ◽  
pp. 515-525 ◽  
Author(s):  
Lilliam M. Valdes-Cruz ◽  
Golde C. Dudell ◽  
Angelo Ferrara ◽  
Barbara J. Nickles
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Disease ◽  
Early Identification ◽  
Clinical Deterioration ◽  
Persistent Pulmonary Hypertension ◽  
Time Interval ◽  
Ejection Time ◽  
Systolic Time Interval ◽  
Systolic Time ◽  
Ventricular Ejection Time

The clinical syndrome of persistent pulmonary hypertension of the newborn (PPHN) still carries high mortality in spite of improved neonatal care. The purpose of this prospective study was to assess the utility of M-mode echocardiography for the early identification of infants with PPHN prior to clinical deterioration. Echocardiograms of 51 infants who needed fractional inspiratory oxygen (FIO2) ≥0.25 to maintain adequate Pao2 within 36 hours of life were compared to those of 115 healthy full-term and preterm newborns. Of the 51 infants, ten had elevated systolic time interval ratios of both ventricles simultaneously (ventricular pre-ejection period to ventricular ejection time [RPEP/RVET ≤0.50, LPEP/LVET ≤0.38J]). All of these newbrns had PPHN that was manifest clinically by 11 to 30 hours of age. The echocardiographic findings preceded clinical deterioration by at least one to five hours in all cases. The other 41 infants had clinical courses consistent with uncomplicated pulmonary disease. These data indicate that systolic time interval ratios, although not accurate measures of pulmonary arterial pressure and/or pulmonary vascular resistance, permit early identification of infants with PPHN and separation from others with uncomplicated pulmonary disease.

Systolic Time Interval Characteristics in Children with Duchenne's Progressive Muscular Dystrophy

PEDIATRICS ◽  
1982 ◽  
Vol 70 (6) ◽  
pp. 958-964
Author(s):  
Shyamal K. Sanyal ◽  
Ralph C. Tierney ◽  
P. Syamasundar Rao ◽  
Samuel E. Pitner ◽  
Stephen L. George ◽  
...  
Keyword(s):  
Heart Rate ◽  
Muscular Dystrophy ◽  
Normal Control ◽  
Left Ventricular ◽  
Time Interval ◽  
Systolic Time Interval ◽  
Control Subjects ◽  
Systolic Time ◽  
Ventricular Ejection Time ◽  
Duchenne's Muscular Dystrophy

Systolic time interval (STI) characteristics of 17 boys with Duchenne's muscular dystrophy (DMD) were compared with those of 80 normal boys who served as control subjects. The heart rate decreased linearly with age in normal control subjects (r = -.47, P < .01). By contrast, heart rate was significantly higher in patients with DMD (P <.001) and tended to increase further with age. Each STI variable for normal control subjects increased significantly with age (P ≤ .01); QII, left ventricular ejection time (LVET), and pre-ejection period (PEP), in addition, decreased with increasing heart rate (P ≤ .05). In dystrophic patients QII and LVET decreased with increasing heart rate (P < .001) but were not influenced by age. None of the other STI values in dystrophic patients was significantly influenced by either age or heart rate. Mean QII, LVET, and QI were shorter and PEP, isometric contraction time (ICT), and PEP/LVET ratio were longer (P < .001) for DMD patients than for normal control subjects. In 13/17 patients, QII and LVET were below the 95% confidence interval of the normal mean, whereas PEP, ICT, and PEP/LVET exceeded the upper limits of normal in 8, 9, and 11 patients, respectively. For dystrophic patients, the difference (Δ) between the observed values and those predicted from regression equations for normal control subjects was lower for QII, LVET, and QI (P < .01) but higher for PEP (P < .04), ICT, and PEP/LVET ratio (P < .001). Δ QII and Δ LVET increased with age (P = .001 and .032, respectively). Duchenne's muscular dystrophy is thus documented to be associated with substantial alterations in STI characteristics that suggest a compromise of global left ventricular performance. Some of these abnormalities increase with age, probably reflecting the progressive cardiomyopathy characteristic of this disease.

SPONTANEOUS VARIATION IN SYSTOLIC TIME INTERVAL

The Lancet ◽  
1979 ◽  
Vol 313 (8112) ◽  
pp. 390-391
Author(s):  
M. Fromer ◽  
E.A. Raeder ◽  
R. Amrein ◽  
D. Burckhardt
Keyword(s):  
Time Interval ◽  
Systolic Time Interval ◽  
Systolic Time
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