scholarly journals Neutron Protein Crystallography : Evaluation of pKa of Polar Amino Acid Residues in Proteins

hamon ◽  
2013 ◽  
Vol 23 (4) ◽  
pp. 282-287
Author(s):  
Nobuo Niimura
Keyword(s):  
Amino Acid ◽  
Protein Crystallography ◽  
Amino Acid Residues ◽  
Polar Amino Acid ◽  
Neutron Protein Crystallography

scholarly journals New Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and Hydroxychloroquine

2020 ◽  
Vol 21 (16) ◽  
pp. 5856
Author(s):  
Davide Gentile ◽  
Virginia Fuochi ◽  
Antonio Rescifina ◽  
Pio Maria Furneri
Keyword(s):  
Hydrogen Bonding ◽  
Amino Acid ◽  
Hydroxyl Group ◽  
Simulation Methods ◽  
Quinoline Derivatives ◽  
Amino Acid Residues ◽  
Polar Amino Acid ◽  
Health Crisis ◽  
E Protein ◽  
Rapid Spread

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a severe global health crisis. In this paper, we used docking and simulation methods to identify potential targets and the mechanism of action of chloroquine (CQ) and hydroxychloroquine (HCQ) against SARS-CoV-2. Our results showed that both CQ and HCQ influenced the functionality of the envelope (E) protein, necessary in the maturation processes of the virus, due to interactions that modify the flexibility of the protein structure. Furthermore, CQ and HCQ also influenced the proofreading and capping of viral RNA in SARS-CoV-2, performed by nsp10/nsp14 and nsp10/nsp16. In particular, HCQ demonstrated a better energy binding with the examined targets compared to CQ, probably due to the hydrogen bonding of the hydroxyl group of HCQ with polar amino acid residues.

Functional analysis of polar amino-acid residues in membrane associated regions of the NHE1 isoform of the mammalian Na+ /H+ exchanger

2001 ◽  
Vol 268 (17) ◽  
pp. 4674-4685 ◽  
Author(s):  
Rakhilya Murtazina ◽  
Brenda J. Booth ◽  
Bonnie L. Bullis ◽  
Dyal N. Singh ◽  
Larry Fliegel
Keyword(s):  
Functional Analysis ◽  
Amino Acid ◽  
Amino Acid Residues ◽  
Polar Amino Acid

scholarly journals Functional role of polar amino acid residues in Na+/H+ exchangers

2001 ◽  
Vol 357 (1) ◽  
pp. 1 ◽  
Author(s):  
Christine A. WIEBE ◽  
Emily R. DiBATTISTA ◽  
Larry FLIEGEL
Keyword(s):  
Amino Acid ◽  
Functional Role ◽  
Amino Acid Residues ◽  
Polar Amino Acid

Isolated Polar Amino Acid Residues Modulate Lipid Binding in the Large Hydrophobic Cavity of CD1d

2016 ◽  
Vol 11 (11) ◽  
pp. 3132-3139 ◽  
Author(s):  
Shinsuke Inuki ◽  
Toshihiko Aiba ◽  
Natsumi Hirata ◽  
Osamu Ichihara ◽  
Daisuke Yoshidome ◽  
...  
Keyword(s):  
Amino Acid ◽  
Lipid Binding ◽  
Amino Acid Residues ◽  
Polar Amino Acid ◽  
Hydrophobic Cavity

scholarly journals Intrinsic contributions of polar amino acid residues toward thermal stability of an ABC-ATPase of mesophilic origin

2003 ◽  
Vol 12 (9) ◽  
pp. 2118-2120 ◽  
Author(s):  
Jyoti Sarin ◽  
Gajendra P.S. Raghava ◽  
Pradip K. Chakraborti
Keyword(s):  
Thermal Stability ◽  
Amino Acid ◽  
Amino Acid Residues ◽  
Polar Amino Acid ◽  
Thermal Stability Of

scholarly journals The Role of Some Polar Amino Acid Residues in Secretin

1977 ◽  
Vol 72 (4) ◽  
pp. 801-802 ◽  
Author(s):  
Miklos Bodanszky ◽  
Mary Lynn Fink ◽  
Guenther Boden
Keyword(s):  
Amino Acid ◽  
Amino Acid Residues ◽  
Polar Amino Acid
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