scholarly journals Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient

2019 ◽  
Vol 28 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Junsung Woo ◽  
Young-Eun Han ◽  
Wuhyun Koh ◽  
Joungha Won ◽  
Min Gu Park ◽  
...  
Keyword(s):  
Optical Signal ◽  
Synaptic Activity ◽  
Functional Coupling ◽  
Intrinsic Optical Signal

scholarly journals Wave onset in central gray matter - its intrinsic optical signal and phase transitions in extracellular polymers

2001 ◽  
Vol 73 (3) ◽  
pp. 351-364 ◽  
Author(s):  
VERA M. FERNANDES-DE-LIMA ◽  
JOÃO E. KOGLER ◽  
JOCELYN BENNATON ◽  
WOLFGANG HANKE
Keyword(s):  
Phase Transition ◽  
Phase Transitions ◽  
Gray Matter ◽  
Action Potentials ◽  
Optical Signal ◽  
Excitable Media ◽  
Extracellular Polymers ◽  
Axon Membrane ◽  
Intrinsic Optical Signal ◽  
Volume Phase

The brain is an excitable media in which excitation waves propagate at several scales of time and space. ''One-dimensional'' action potentials (millisecond scale) along the axon membrane, and spreading depression waves (seconds to minutes) at the three dimensions of the gray matter neuropil (complex of interacting membranes) are examples of excitation waves. In the retina, excitation waves have a prominent intrinsic optical signal (IOS). This optical signal is created by light scatter and has different components at the red and blue end of the spectrum. We could observe the wave onset in the retina, and measure the optical changes at the critical transition from quiescence to propagating wave. The results demonstrated the presence of fluctuations preceding propagation and suggested a phase transition. We have interpreted these results based on an extrapolation from Tasaki's experiments with action potentials and volume phase transitions of polymers. Thus, the scatter of red light appeared to be a volume phase transition in the extracellular matrix that was caused by the interactions between the cellular membrane cell coat and the extracellular sugar and protein complexes. If this hypothesis were correct, then forcing extracellular current flow should create a similar signal in another tissue, provided that this tissue was also transparent to light and with a similarly narrow extracellular space. This control tissue exists and it is the crystalline lens. We performed the experiments and confirmed the optical changes. Phase transitions in the extracellular polymers could be an important part of the long-range correlations found during wave propagation in central nervous tissue.

scholarly journals Causal relationship between local field potential and intrinsic optical signal in epileptiform activity in vitro

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zsigmond Benkő ◽  
Kinga Moldován ◽  
Katalin Szádeczky-Kardoss ◽  
László Zalányi ◽  
Sándor Borbély ◽  
...  
Keyword(s):  
Causal Relationship ◽  
Local Field ◽  
Local Field Potential ◽  
Epileptiform Activity ◽  
Field Potential ◽  
Optical Signal ◽  
Intrinsic Optical Signal

Peri-infarct temporal changes in intrinsic optical signal during spreading depression in focal ischemic rat cortex

2007 ◽  
Vol 424 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Zhen Wang ◽  
Pengcheng Li ◽  
Weihua Luo ◽  
Shangbin Chen ◽  
Qingming Luo
Keyword(s):  
Spreading Depression ◽  
Optical Signal ◽  
Temporal Changes ◽  
Rat Cortex ◽  
Intrinsic Optical Signal

scholarly journals Intrinsic optical signal imaging 
of glucose-stimulated insulin secreting β-cells

2010 ◽  
Vol 19 (1) ◽  
pp. 99 ◽  
Author(s):  
Yi-Chao Li ◽  
Wan-Xing Cui ◽  
Xu-Jing Wang ◽  
Franklin Amthor ◽  
Rong-Wen Lu ◽  
...  
Keyword(s):  
Optical Signal ◽  
Β Cells ◽  
Intrinsic Optical Signal

Evaluation of a transparent cranial implant for multi-wavelength intrinsic optical signal imaging

2019 ◽  
Author(s):  
Nami Davoodzadeh ◽  
Mildred s. Cano-Velázquez ◽  
David L. Halaney ◽  
Carrie R. Jonak ◽  
Devin K. Binder ◽  
...  
Keyword(s):  
Optical Signal ◽  
Intrinsic Optical Signal ◽  
Multi Wavelength ◽  
Cranial Implant
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