scholarly journals Sex-specific Behavioral Features of Rodent Models of Autism Spectrum Disorder

2018 ◽  
Vol 27 (5) ◽  
pp. 321-343 ◽  
Author(s):  
Se Jin Jeon ◽  
Edson Luck Gonzales ◽  
Darine Froy N. Mabunga ◽  
Schley T. Valencia ◽  
Do Gyeong Kim ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Rodent Models ◽  
Behavioral Features

Brief Report: Association Between Behavioral Features and Gastrointestinal Problems Among Children with Autism Spectrum Disorder

2011 ◽  
Vol 42 (7) ◽  
pp. 1520-1525 ◽  
Author(s):  
Matthew J. Maenner ◽  
Carrie L. Arneson ◽  
Susan E. Levy ◽  
Russell S. Kirby ◽  
Joyce S. Nicholas ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Gastrointestinal Problems ◽  
Behavioral Features

scholarly journals W12. BEHAVIORAL MANIFESTATIONS IN GENETIC RODENT MODELS OF AUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW AND META-ANALYSES

2021 ◽  
Vol 51 ◽  
pp. e153-e154
Author(s):  
Alana Panzenhagen ◽  
Ana Paula Herrmann ◽  
Leandro Bertoglio ◽  
Amanda Cavalcanti ◽  
Dirson Stein ◽  
...  
Keyword(s):  
Systematic Review ◽  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Rodent Models ◽  
Meta Analyses

scholarly journals Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248771
Author(s):  
Zarazuela Zolkipli-Cunningham ◽  
Jane C. Naviaux ◽  
Tomohiro Nakayama ◽  
Charlotte M. Hirsch ◽  
Jonathan M. Monk ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Immune Activation ◽  
Purinergic Signaling ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Whole Body ◽  
Systemic Injection ◽  
Maternal Immune Activation ◽  
Behavioral Features ◽  
Rebound Increase

Since 2012, studies in mice, rats, and humans have suggested that abnormalities in purinergic signaling may be a final common pathway for many genetic and environmental causes of autism spectrum disorder (ASD). The current study in mice was conducted to characterize the bioenergetic, metabolomic, breathomic, and behavioral features of acute hyperpurinergia triggered by systemic injection of the purinergic agonist and danger signal, extracellular ATP (eATP). Responses were studied in C57BL/6J mice in the maternal immune activation (MIA) model and controls. Basal metabolic rates and locomotor activity were measured in CLAMS cages. Plasma metabolomics measured 401 metabolites. Breathomics measured 98 volatile organic compounds. Intraperitoneal eATP dropped basal metabolic rate measured by whole body oxygen consumption by 74% ± 6% (mean ± SEM) and rectal temperature by 6.2˚ ± 0.3˚C in 30 minutes. Over 200 metabolites from 37 different biochemical pathways where changed. Breathomics showed an increase in exhaled carbon monoxide, dimethylsulfide, and isoprene. Metabolomics revealed an acute increase in lactate, citrate, purines, urea, dopamine, eicosanoids, microbiome metabolites, oxidized glutathione, thiamine, niacinamide, and pyridoxic acid, and decreased folate-methylation-1-carbon intermediates, amino acids, short and medium chain acyl-carnitines, phospholipids, ceramides, sphingomyelins, cholesterol, bile acids, and vitamin D similar to some children with ASD. MIA animals were hypersensitive to postnatal exposure to eATP or poly(IC), which produced a rebound increase in body temperature that lasted several weeks before returning to baseline. Acute hyperpurinergia produced metabolic and behavioral changes in mice. The behaviors and metabolic changes produced by ATP injection were associated with mitochondrial functional changes that were profound but reversible.

scholarly journals Metabolic and Behavioral Features of Acute Hyperpurinergia and the Connection to Autism Spectrum Disorder

2020 ◽  
Author(s):  
Zarazuela Zolkipli-Cunningham ◽  
Jane C. Naviaux ◽  
Tomohiro Nakayama ◽  
Charlotte M. Hirsch ◽  
Jonathan M. Monk ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Purinergic Signaling ◽  
Krebs Cycle ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Whole Body ◽  
Systemic Injection ◽  
Functional Changes ◽  
Children With Asd ◽  
Behavioral Features

Abstract Background. Since 2012, studies in mice, rats, and humans have suggested that abnormalities in purinergic signaling may be a final common pathway for many genetic and environmental causes of autism spectrum disorder (ASD). The current study in mice was conducted to characterize the bioenergetic, metabolomic, breathomic, and behavioral features of acute hyperpurinergia triggered by systemic injection of the purinergic agonist and danger signal, extracellular ATP (eATP). Methods. Responses were studied in C57BL/6J mice with ASD-like behaviors in the maternal immune activation (MIA) model and controls. Basal metabolic rates, respiratory exchange ratios (RER = VCO2/VO2), and locomotor activity were measured in CLAMS cages. Plasma metabolomics measured 401 metabolites. Breathomics measured 98 volatile organic compounds. Results. A 0.5 µmol/g dose of ATP dropped whole body oxygen consumption by 74% ± 6% (mean ± SEM, 5,303 to 1,382 ml/kg/hr, p<0.0001) and rectal temperature by 6.2˚ ± 0.3˚C (p<0.0001) in 30 minutes. Over 200 metabolites from 37 different biochemical pathways where changed. MIA animals were hypersensitive to the metabolic and behavioral responses triggered by eATP and poly(IC). Breathomic and metabolomic analysis revealed changes in folate-methylation-1-carbon, purines, pyrimidines, acyl-carnitines, glycolysis, aromatic and branch-chain amino acids, Krebs cycle, glutathione, urea cycle, phospholipids, sphingolipids, eicosanoids, cholesterol, bile acids, vitamins, and microbiome metabolism similar to children with ASD. Limitations. The responses to ATP were studied in only a single genetic strain of mice (C57BL/6J). Although similar to metabolic results reported in FVB mice and a small clinical trial in children with ASD, the generalizability of these results to larger studies in humans is unknown. The chronic effects of repeated postnatal ATP exposures were not tested. Conclusions. Acute hyperpurinergia produced metabolic and behavioral changes in mice that were similar to those found in children with ASD. These behaviors and metabolic changes were associated with mitochondrial functional changes that were profound but reversible.

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