scholarly journals The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning

2018 ◽  
Vol 27 (3) ◽  
pp. 139-154 ◽  
Author(s):  
Hyun Geun Shim ◽  
Yong-Seok Lee ◽  
Sang Jeong Kim
Keyword(s):  
Motor Learning ◽  
Purkinje Cells ◽  
Intrinsic Excitability ◽  
Intrinsic Plasticity ◽  
Cerebellar Purkinje Cells ◽  
Activity Dependent

scholarly journals Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells

Cell Reports ◽  
2016 ◽  
Vol 14 (11) ◽  
pp. 2546-2553 ◽  
Author(s):  
Giorgio Grasselli ◽  
Qionger He ◽  
Vivian Wan ◽  
John P. Adelman ◽  
Gen Ohtsuki ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Dependent Plasticity ◽  
Cerebellar Purkinje Cells ◽  
Activity Dependent

scholarly journals Motor learning of mice lacking cerebellar Purkinje cells

2013 ◽  
Vol 7 ◽  
Author(s):  
M. Elena Porras-García ◽  
Rocío Ruiz ◽  
Eva M. Pérez-Villegas ◽  
José Á. Armengol
Keyword(s):  
Motor Learning ◽  
Purkinje Cells ◽  
Cerebellar Purkinje Cells

scholarly journals mGlu1 receptor mediates homeostatic control of intrinsic excitability through Ih in cerebellar Purkinje cells

2016 ◽  
Vol 115 (5) ◽  
pp. 2446-2455 ◽  
Author(s):  
Hyun Geun Shim ◽  
Sung-Soo Jang ◽  
Dong Cheol Jang ◽  
Yunju Jin ◽  
Wonseok Chang ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Neuronal Activity ◽  
Metabotropic Glutamate Receptor ◽  
Activity Level ◽  
Network Activity ◽  
Firing Rates ◽  
Metabotropic Glutamate ◽  
Gated Channel ◽  
Intrinsic Plasticity ◽  
Cerebellar Purkinje Cells

Homeostatic intrinsic plasticity is a cellular mechanism for maintaining a stable neuronal activity level in response to developmental or activity-dependent changes. Type 1 metabotropic glutamate receptor (mGlu1 receptor) has been widely known to monitor neuronal activity, which plays a role as a modulator of intrinsic and synaptic plasticity of neurons. Whether mGlu1 receptor contributes to the compensatory adjustment of Purkinje cells (PCs), the sole output of the cerebellar cortex, in response to chronic changes in excitability remains unclear. Here, we demonstrate that the mGlu1 receptor is involved in homeostatic intrinsic plasticity through the upregulation of the hyperpolarization-activated current ( Ih) in cerebellar PCs. This plasticity was prevented by inhibiting the mGlu1 receptor with Bay 36–7620, an mGlu1 receptor inverse agonist, but not with CPCCOEt, a neutral antagonist. Chronic inactivation with tetrodotoxin (TTX) increased the components of Ih in the PCs, and ZD 7288, a hyperpolarization-activated cyclic nucleotide-gated channel selective inhibitor, fully restored reduction of firing rates in the deprived neurons. The homeostatic elevation of Ih was also prevented by BAY 36–7620, but not CPCCOEt. Furthermore, KT 5720, a blocker of protein kinase A (PKA), prevented the effect of TTX reducing the evoked firing rates, indicating the reduction in excitability of PCs due to PKA activation. Our study shows that both the mGlu1 receptor and the PKA pathway are involved in the homeostatic intrinsic plasticity of PCs after chronic blockade of the network activity, which provides a novel understanding on how cerebellar PCs can preserve the homeostatic state under activity-deprived conditions.

scholarly journals Mid-lateral Cerebellar Purkinje Cells Provide a Cognitive Error Signal When Monkeys Learn a New Visuomotor Association

2019 ◽  
Author(s):  
Naveen Sendhilnathan ◽  
Anna E. Ipata ◽  
Michael E. Goldberg
Keyword(s):  
Motor Learning ◽  
Purkinje Cells ◽  
Visual Cues ◽  
Hand Movement ◽  
Red Light ◽  
Population Level ◽  
Learning System ◽  
Error Signal ◽  
Association Learning ◽  
Cerebellar Purkinje Cells

AbstractHow do we learn to establish associations between arbitrary visual cues (like a red light) and movements (like braking the car)? We investigated the neural correlates of visuomotor association learning in the monkey mid-lateral cerebellum. Here we show that, during learning but not when the associations were overlearned, individual Purkinje cells reported the outcome of the monkey’s most recent decision, an error signal, which was independent of changes in hand movement or reaction time. At the population level, Purkinje cells collectively maintained a memory of the most recent decision throughout the entire trial period, updating it after every decision. This error signal decreased as the performance improved. Our results suggest a role of mid-lateral cerebellum in visuomotor associative learning and provide evidence that cerebellum could be a generalized learning system, essential in non-motor learning as well as motor learning.

Thiamine Deficiency Increases Intrinsic Excitability of Mouse Cerebellar Purkinje Cells

2020 ◽  
Author(s):  
Ivonne Carolina Bolaños-Burgos ◽  
Ana María Bernal-Correa ◽  
Germán Arturo Bohórquez Mahecha ◽  
Ângela Maria Ribeiro ◽  
Christopher Kushmerick
Keyword(s):  
Purkinje Cells ◽  
Thiamine Deficiency ◽  
Intrinsic Excitability ◽  
Cerebellar Purkinje Cells

scholarly journals Intrinsic Excitability Increase in Cerebellar Purkinje Cells Following Delay Eyeblink Conditioning in Mice

2018 ◽  
Author(s):  
Heather K. Titley ◽  
Gabrielle V. Watkins ◽  
Carmen Lin ◽  
Craig Weiss ◽  
Michael McCarthy ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Neuronal Excitability ◽  
Eyeblink Conditioning ◽  
Underlying Mechanism ◽  
Learning Task ◽  
Sk Channels ◽  
Calcium Dependent ◽  
Cerebellar Learning ◽  
Intrinsic Plasticity ◽  
Cerebellar Purkinje Cells

AbstractCerebellar learning is canonically thought to rely on synaptic plasticity, particularly at synaptic inputs to Purkinje cells. Recently, however, other complementary mechanisms have been identified. Intrinsic plasticity is one such mechanism, and depends in part on the down-regulation of calcium-dependent SK-type K channels, which is associated with an increase in neuronal excitability. In the hippocampus, SK-mediated intrinsic plasticity has been shown to play a role in trace eyeblink conditioning; however, it is not yet known how intrinsic plasticity contributes to a cerebellar learning task such as delay eyeblink conditioning. Whole cell recordings were obtained from acute cerebellar slices from mice ~48 hours after learning a delay eyeblink conditioning task. Over a period of repeated training sessions mice received either distinctly paired trials of a tone co-terminating with a periorbital shock (conditioned mice) or trials in which these stimuli were presented in an unpaired manner (pseudoconditioned mice). Conditioned mice show a significantly reduced afterhyperpolarization (AHP) following trains of parallel fiber stimuli. Moreover, we find that SK-dependent intrinsic plasticity is occluded in conditioned, but not pseudoconditioned mice. These findings show that excitability is enhanced in Purkinje cells after delay eyeblink conditioning and point toward a downregulation of SK channels as a potential underlying mechanism.

scholarly journals Synaptic and intrinsic plasticity coordinate spike output in cerebellar Purkinje cells

2019 ◽  
Author(s):  
Hyun Geun Shim ◽  
Sang Jeong Kim
Keyword(s):  
Intracellular Signaling ◽  
Synaptic Weight ◽  
Spike Discharge ◽  
Intrinsic Plasticity ◽  
Cerebellar Purkinje Cells ◽  
Dendritic Branches ◽  
The Impact ◽  
Activity Dependent ◽  
Timing Rules

SummaryLearning has been thought to be implemented by activity-dependent modifications of synaptic weight and intrinsic excitability. Here, we highlight how long-term depression at parallel fiber to Purkinje cell synapses (PF-PC LTD) and intrinsic plasticity of PCs coordinate the postsynaptic spike discharge from C57BL/6 male mice. Intrinsic plasticity of PCs in the flocculus matched the timing rules and shared intracellular signaling for PF-PC LTD. Notably, the intrinsic plasticity was confined to the dendritic branches where the synaptic plasticity is formed. Besides, when either synaptic or intrinsic plasticity was impaired, the impact of PF inputs was less reflected by the spike output of PCs. In conclusion, synergies between synaptic and intrinsic plasticity may play a role in tuning the PC output, thereby achieving optimal ranges of output.

scholarly journals Intrinsic Excitability Increase in Cerebellar Purkinje Cells after Delay Eye-Blink Conditioning in Mice

2020 ◽  
Vol 40 (10) ◽  
pp. 2038-2046 ◽  
Author(s):  
Heather K. Titley ◽  
Gabrielle V. Watkins ◽  
Carmen Lin ◽  
Craig Weiss ◽  
Michael McCarthy ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Intrinsic Excitability ◽  
Eye Blink ◽  
Cerebellar Purkinje Cells
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