scholarly journals Black Rice (Oryza sativa L ., Poaceae) Extract Reduces Hippocampal Neuronal Cell Death Induced by Transient Global Cerebral Ischemia in Mice

2018 ◽  
Vol 27 (2) ◽  
pp. 129-138 ◽  
Author(s):  
Sun-Nyoung Hwang ◽  
Jae-Cheon Kim ◽  
Mohammad Iqbal Hossain Bhuiyan ◽  
Joo Youn Kim ◽  
Ji Seon Yang ◽  
...  
Keyword(s):  
Cell Death ◽  
Oryza Sativa ◽  
Cerebral Ischemia ◽  
Oryza Sativa L ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Global Cerebral Ischemia ◽  
Black Rice ◽  
Transient Global Cerebral Ischemia

Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice

2011 ◽  
Vol 499 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Simone E. Thal ◽  
Changlian Zhu ◽  
Serge C. Thal ◽  
Klas Blomgren ◽  
Nikolaus Plesnila
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Global Cerebral Ischemia ◽  
Apoptosis Inducing Factor

scholarly journals Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia

2009 ◽  
Vol 1265 ◽  
pp. 138-147 ◽  
Author(s):  
Quan-Guang Zhang ◽  
Ruimin Wang ◽  
Dong Han ◽  
Yan Dong ◽  
Darrell W. Brann
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Global Cerebral Ischemia ◽  
Jnk Signaling ◽  
Rac1 Gtpase ◽  
Delayed Neuronal Cell Death

scholarly journals miR-380-5p facilitates NRF2 and attenuates cerebral ischemia/reperfusion injury-induced neuronal cell death by directly targeting BACH1

2021 ◽  
Vol 12 (1) ◽  
pp. 210-217
Author(s):  
Yibiao Wang ◽  
Min Xu
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Luciferase Assay ◽  
Neuroprotective Effects ◽  
Cerebral Ischemia Reperfusion

Abstract Background This study aimed to explore the role of miR-380-5p in cerebral ischemia/reperfusion (CIR) injury-induced neuronal cell death and the potential signaling pathway involved. Methodology Human neuroblastoma cell line SH-SY5Y cells were used in this study. Oxygen and glucose deprivation/reperfusion (OGD/R) model was used to mimic ischemia/reperfusion injury. CCK-8 assay and flow cytometry were used to examine cell survival. Quantitative real time PCR (RT-qPCR) assay and Western blotting were used to measure the change of RNA and protein expression, respectively. TargetScan and Luciferase assay was used to confirm the target of miR-380-5p. Malondialdehyde (MDA) superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) were measured using commercial kits. Results miR-380-5p was downregulated in SH-SY5Y cells after OGD/R. Cell viability was increased by miR-380-5p, while cell apoptosis was reduced by miR-380-5p mimics. MDA was reduced by miR-380-5p mimics, while SOD and GSHPx were increased by miR-380-5p. Results of TargetScan and luciferase assay have showed that BACH1 is the direct target of miR-380-5p. Expression of NRF2 was upregulated after OGD/R, but was not affected by miR-380-5p. mRNA expression of HO-1 and NQO1 and ARE activity were increased by miR-380-5p. Overexpression of BACH1 reversed the antioxidant and neuroprotective effects of miR-380-5p. Conclusion miR-380-5p inhibited cell death induced by CIR injury through target BACH1 which also facilitated the activation of NRF2, indicating the antioxidant and neuroprotective effects of miR-380-5p.

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