scholarly journals Comparison between Flail Arm Syndrome and Upper Limb Onset Amyotrophic Lateral Sclerosis: Clinical Features and Electromyographic Findings

2014 ◽  
Vol 23 (3) ◽  
pp. 253-257 ◽  
Author(s):  
Byung-Nam Yoon ◽  
Seong Hye Choi ◽  
Joung-Ho Rha ◽  
Sa-Yoon Kang ◽  
Kwang-Woo Lee ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Clinical Features ◽  
Upper Limb ◽  
Lateral Sclerosis ◽  
Limb Onset

scholarly journals Relative preservation of triceps over biceps strength in upper limb-onset ALS: the ‘split elbow’

2019 ◽  
Vol 90 (7) ◽  
pp. 730-733 ◽  
Author(s):  
Roaya Khalaf ◽  
Sarah Martin ◽  
Cathy Ellis ◽  
Rachel Burman ◽  
Jemeen Sreedharan ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Upper Limb ◽  
Selective Vulnerability ◽  
Relative Strength ◽  
Rank Test ◽  
Cortical Representation ◽  
Signed Rank Test ◽  
South East England ◽  
Lateral Sclerosis ◽  
Limb Onset

ObjectiveAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor system. The split hand sign in ALS refers to observed preferential weakness of the lateral hand muscles, which is unexplained. One possibility is larger cortical representation of the lateral hand compared with the medial. Biceps strength is usually preserved relative to triceps in neurological conditions, but biceps has a larger cortical representation and might be expected to show preferential weakness in ALS.MethodsUsing the South-East England Register for Amyotrophic Lateral Sclerosis, we performed a retrospective longitudinal cohort study and extracted the modified Medical Research Council (MRC) muscle strength score for biceps and triceps in patients with a diagnosis of upper limb-onset ALS in the 19-year period 1996–2015. A Wilcoxon signed-rank test was used to assess the relative strength of the muscles within the total sum of the upper limbs involved in the study.ResultsThere were 659 people with upper limb onset of weakness. In 215 there were insufficient data to perform the analysis, and a further 33 were excluded for other reasons, leaving 411 for analysis. Biceps was stronger than triceps in 87 limbs, and triceps was stronger than biceps in 258 limbs, with no difference seen in the remaining 477. Triceps strength scores (mean rank=186.1) were higher than ipsilateral biceps strength scores (mean rank=134.2), Z=−10.1, p<0.001 (two-tailed).ConclusionTriceps strength is relatively preserved compared with biceps in ALS. This is consistent with a broadly corticofugal hypothesis of selective vulnerability, in which susceptibility might be associated with larger cortical representation.

Respiratory function deterioration is not time-linked with upper-limb onset in amyotrophic lateral sclerosis

2009 ◽  
Vol 92 (3) ◽  
pp. 261-264 ◽  
Author(s):  
J. Martí-Fàbregas ◽  
M. Dourado ◽  
J. Sanchis ◽  
R. Miralda ◽  
J. Pradas ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Upper Limb ◽  
Respiratory Function ◽  
Lateral Sclerosis ◽  
Limb Onset

scholarly journals Correlation of Creatine Kinase Levels with Clinical Features and Survival in Amyotrophic Lateral Sclerosis

2017 ◽  
Vol 8 ◽  
Author(s):  
Hongfei Tai ◽  
Liying Cui ◽  
Yuzhou Guan ◽  
Mingsheng Liu ◽  
Xiaoguang Li ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Creatine Kinase ◽  
Clinical Features ◽  
Lateral Sclerosis

Clinical features of amyotrophic lateral sclerosis in south-west China

2015 ◽  
Vol 16 (7-8) ◽  
pp. 512-519 ◽  
Author(s):  
Qianqian Wei ◽  
Xueping Chen ◽  
Zhenzhen Zheng ◽  
Rui Huang ◽  
Xiaoyan Guo ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Clinical Features ◽  
West China ◽  
South West ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis in Nordland county, Norway, 2000–2015: prevalence, incidence, and clinical features

2018 ◽  
Vol 19 (7-8) ◽  
pp. 522-527 ◽  
Author(s):  
Espen Benjaminsen ◽  
Karl B. Alstadhaug ◽  
Marie Gulsvik ◽  
Farid K. Baloch ◽  
Francis Odeh
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Clinical Features ◽  
Lateral Sclerosis
Sign in / Sign up

Export Citation Format

Share Document