Celecoxib Attenuates Kainic Acid-induced Neuronal Cell Death Through Suppression of Microglial c-Jun N-terminal Kinase Phosphorylation

2009 ◽  
Vol 18 (1) ◽  
pp. 13 ◽  
Author(s):  
Jong-Seon Byun ◽  
So-Young Cho ◽  
Song-In Kim ◽  
Yong-Soo Kwon ◽  
Seong-Ho Jeon ◽  
...  
Keyword(s):  
Cell Death ◽  
Kainic Acid ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Kinase Phosphorylation

scholarly journals Bark Constituents from Mushroom-detoxifiedRhus vernicifluaSuppress Kainic Acid-induced Neuronal Cell Death in Mouse Hippocampus

2010 ◽  
Vol 14 (5) ◽  
pp. 279 ◽  
Author(s):  
Jong-Seon Byun ◽  
Yoon Hee Han ◽  
Sung-Jun Hong ◽  
Sung-Mi Hwang ◽  
Yong-Soo Kwon ◽  
...  
Keyword(s):  
Cell Death ◽  
Kainic Acid ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Mouse Hippocampus

scholarly journals Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus

2010 ◽  
Vol 205 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Jiyeon Lee ◽  
Eunjin Lim ◽  
Yumi Kim ◽  
Endan Li ◽  
Seungjoon Park
Keyword(s):  
Cell Death ◽  
Kainic Acid ◽  
Hippocampal Neurons ◽  
Therapeutic Potential ◽  
Excitatory Amino Acid ◽  
Neuroprotective Effect ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Proinflammatory Mediators ◽  
Hippocampal Neurodegeneration

Ghrelin is an endogenous ligand for GH secretagogue receptor type 1a (GHSR1a), and is produced and released mainly from the stomach. It has been recently demonstrated that ghrelin can function as a neuroprotective factor by inhibiting apoptotic pathways. Kainic acid (KA), an excitatory amino acid l-glutamate analog, causes neuronal death in the hippocampus; previous studies suggest that activated microglia and astrocytes actively participate in the pathogenesis of KA-induced hippocampal neurodegeneration. However, it is unclear whether ghrelin has neuroprotective effect in KA-induced hippocampal neurodegeneration. I.p. injection of KA produced typical neuronal cell death in the CA1 and CA3 pyramidal layers of the hippocampus, and the systemic administration of ghrelin significantly attenuated KA-induced neuronal cell death in these regions through the activation of GHSR1a. Ghrelin prevents KA-induced activation of microglia and astrocytes, and the expression of proinflammatory mediators tumor necrosis factor α, interleukin-1β, and cyclooxygenase-2. The inhibitory effect of ghrelin on the activation of microglia and astrocytes appears to be associated with the inhibition of matrix metalloproteinase-3 expression in damaged hippocampal neurons. Our data suggest that ghrelin has a therapeutic potential for suppressing KA-induced pathogenesis in the brain.

scholarly journals Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death

Brain ◽  
2008 ◽  
Vol 131 (11) ◽  
pp. 3019-3033 ◽  
Author(s):  
Ik-Hyun Cho ◽  
Jinpyo Hong ◽  
Eun Cheng Suh ◽  
Jae Hwan Kim ◽  
Hyunkyoung Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Kainic Acid ◽  
Neuronal Cell Death ◽  
Neuronal Cell

scholarly journals Glycyrrhizin Attenuates Kainic Acid-Induced Neuronal Cell Death in the Mouse Hippocampus

2013 ◽  
Vol 22 (2) ◽  
pp. 107-115 ◽  
Author(s):  
Lidan Luo ◽  
Yinchuan Jin ◽  
Il-Doo Kim ◽  
Ja-Kyeong Lee
Keyword(s):  
Cell Death ◽  
Kainic Acid ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Mouse Hippocampus

scholarly journals Protective Effects of Bupivacaine against Kainic Acid-Induced Seizure and Neuronal Cell Death in the Rat Hippocampus

2015 ◽  
Vol 38 (4) ◽  
pp. 522-530 ◽  
Author(s):  
Kuan Ming Chiu ◽  
Chia Chan Wu ◽  
Ming Jiuh Wang ◽  
Ming Yi Lee ◽  
Su Jane Wang
Keyword(s):  
Cell Death ◽  
Kainic Acid ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Rat Hippocampus ◽  
Protective Effects

scholarly journals Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitors

2002 ◽  
Vol 135 (5) ◽  
pp. 1297-1307 ◽  
Author(s):  
Ester Verdaguer ◽  
Elvira García-Jordà ◽  
Andrés Jiménez ◽  
Alessandra Stranges ◽  
Francesc X Sureda ◽  
...  
Keyword(s):  
Cell Death ◽  
Kainic Acid ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Cerebellar Granule ◽  
Caspase Inhibitors
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