scholarly journals A Single Dose of Indomethacin Does Not Prolong Premotor Reaction Time in Young, Healthy Adults: A Randomized, Placebo-Controlled, Double-Blind, Cross-Over Study

2012 ◽  
Vol 27 (1) ◽  
pp. 24-30
Author(s):  
Özden Özyemişci Taşkıran
Keyword(s):  
Single Dose ◽  
Reaction Time ◽  
Healthy Adults ◽  
Double Blind ◽  
Premotor Reaction Time

scholarly journals Randomized, Double-Blind Study in Healthy Adults to Assess the Boosting Effect of Vaqta or Havrix after a Single Dose of Havrix

2001 ◽  
Vol 32 (3) ◽  
pp. 396-401 ◽  
Author(s):  
B. A. Connor ◽  
J. Phair ◽  
D. Sack ◽  
D. McEniry ◽  
R. Hornick ◽  
...  
Keyword(s):  
Single Dose ◽  
Healthy Adults ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

Comparison of the Diuretic Effects of Single Dose Frusemide/Triamterene and Hydrochlorothiazide/Amiloride in Healthy Adults

1986 ◽  
Vol 14 (4) ◽  
pp. 188-192
Author(s):  
A Kohvakka ◽  
E Hussi
Keyword(s):  
Single Dose ◽  
Fixed Combination ◽  
Healthy Adults ◽  
Controlled Study ◽  
Urinary Volume ◽  
Double Blind ◽  
Double Blind Placebo

The diuretic and potassium- and magnesium-conserving action of a single dose of frusemide/triamterene, F+TRI (40 mg/50 mg), and hydrochlorothiazide/amiloride, HCT+AMI (50 mg/5 mg), fixed combination preparations were compared in ten healthy adults in a randomised double-blind placebo-controlled study. Urinary volume during 24 hours was significantly higher after HCT+AMI ingestion than after F+TRI. The urine and sodium excretions caused by HCT+AMI lasted markedly longer and were smoother than the short and somewhat unpleasant effects of F+ TRI. HCT+AMI also spared potassium and magnesium relatively more effectively than F + TRI.

Mono- and diglycerides improve lutein absorption in healthy adults: a randomised, double-blind, cross-over, single-dose study

2017 ◽  
Vol 118 (10) ◽  
pp. 813-821 ◽  
Author(s):  
Barbara J. Marriage ◽  
Jennifer A. Williams ◽  
Yong S. Choe ◽  
Kevin C. Maki ◽  
Mustafa Vurma ◽  
...  
Keyword(s):  
Single Dose ◽  
Peak Level ◽  
Study Data ◽  
Primary Objective ◽  
Healthy Adults ◽  
Double Blind Study ◽  
Double Blind ◽  
Single Dose Study ◽  
High Oleic ◽  
Time To Peak

AbstractWith the association between increased carotenoid intake and lower risk of chronic diseases, the absorption of lutein from the diet becomes an important factor in its delivery and physiological action. The primary objective of this study was to gain an understanding of how a new formulation technology (mixture of mono- and diglycerides (MDG)), affected lutein absorption. Subjects (n24) were randomised in a cross-over, double-blind study to receive a single dose of 6 mg lutein (FloraGLO 20 %) provided as capsules containing either high-oleic safflower (SAF) oil or a MDG oil. Subjects receiving a single dose of lutein in MDG showed a significantly greater change from baseline (0 h) to 4, 6, 8, 12, 24, 48 and 336 h (P<0·05) and baseline adjusted AUC for plasma lutein at 48 and 336 h (P<0·001) as compared with subjects given lutein in SAF. Analysis of the 48 h absorption kinetics of lutein showed that the time to peak level of lutein (12 h) was the same for SAF and MDG groups, but the change in plasma lutein at 12 and 48 h were 129 and 320 % higher, respectively, for MDG compared with SAF. This difference continued as the adjusted AUC 0–48 and 0–336 h for the MDG group was 232 and 900 % higher, respectively, v. SAF. The study data show that by changing the lipid that is combined with a lutein supplement results in significant increases in lutein absorption in healthy adults.

A clinical method of evaluating simple reaction time and reaction accuracy is sensitive to a single dose of lorazepam

2020 ◽  
Vol 34 (8) ◽  
pp. 920-925
Author(s):  
James K Richardson ◽  
James T Eckner ◽  
Hogene Kim ◽  
James A Ashton-Miller
Keyword(s):  
Single Dose ◽  
Reaction Time ◽  
Simple Reaction Time ◽  
Motor Vehicle ◽  
Time Variability ◽  
Reaction Time Variability ◽  
Cognitive Changes ◽  
Double Blind ◽  
Clinical Method ◽  
Simple Reaction

Rationale: Benzodiazepines are useful and commonly prescribed. Unfortunately, they are associated with subtle but functionally significant neurocognitive side effects that increase the risk of motor vehicle accidents and falls. Objective: The objective of this study was to determine whether clinically feasible measures of simple reaction time and reaction accuracy are sensitive to a single dose of lorazepam. Methods: Using a randomized, double-blind, crossover design, 26 healthy adults (13 women; age = 26.9 ± 8.2 yr) were given 1.0 mg lorazepam or placebo 90 minutes prior to two data collection sessions. Participants completed simple and reaction accuracy tasks using a standardized “ruler drop” testing paradigm during each session. Outcomes were mean and variability of simple reaction time and reaction accuracy, which evaluates a participant’s ability to catch the device solely on the random 50% of trials that lights affixed to it illuminate on release. Reaction accuracy requires a go/no-go decision within 420 ms before the falling device strikes the floor. Results: As compared with placebo, lorazepam increased simple reaction time variability (range = 43 ± 18 vs. 60 ± 23 ms, respectively; p = 0.004 and standard deviation = 14.6 ± 5.7 vs. 19.7 ± 7.3 ms, respectively; = 0.006) and decreased reaction accuracy (90 ± 7% vs. 84 ± 11%, respectively; p = 0.010). Conclusion: Given prior work demonstrating associations between simple reaction time and reaction accuracy and functional outcomes such as self-protection, response to perturbations, and fall risk, these clinically available measures may have a role in identifying subtle, functionally significant cognitive changes related to short-term benzodiazepine use.

Effect of Diazepam on Visuomotor Reaction Time

1985 ◽  
Vol 60 (1) ◽  
pp. 107-110 ◽  
Author(s):  
James G. Barbee ◽  
Iryna Lawriw Black
Keyword(s):  
Single Dose ◽  
Reaction Time ◽  
Reaction Times ◽  
Double Blind Study ◽  
Dominant Hand ◽  
Time Intervals ◽  
Female Adult ◽  
Double Blind ◽  
Nondominant Hand ◽  
The Difference

20 male and 10 female adult, normal, healthy subjects, whose mean age was 26.34 yr., participated in a double-blind study of the effect of a single dose (0.2 mg./kg. of body weight) of diazepam on visuomotor reaction time. Reaction time was measured before drug administration, and 60 min., and 120 min. after administration. Separate reaction times for the dominant and nondominant hand were recorded. There were no significant differences between the diazepam and placebo group at each of the three time intervals. Diazepam in the single dose employed does not appear to affect adversely visuomotor reaction time of relatively young, normal, healthy adults. For both groups the difference in visuomotor reaction time between the dominant hand and the nondominant hand was statistically significant as expected.

The Effect of Warfarin Sodium on the Duration of Platelet Aggregation

1967 ◽  
Vol 18 (03/04) ◽  
pp. 766-778 ◽  
Author(s):  
H. J Knieriem ◽  
A. B Chandler
Keyword(s):  
Platelet Count ◽  
Placebo Group ◽  
Platelet Aggregation ◽  
Prothrombin Time ◽  
Platelet Rich Plasma ◽  
Healthy Adults ◽  
Double Blind Study ◽  
Double Blind ◽  
Warfarin Sodium

SummaryThe effect of the administration of warfarin sodium (Coumadin®) on the duration of platelet aggregation in vitro was studied. Coumadin was given for 4 consecutive days to 10 healthy adults who were followed over a period of 9 days. The duration of adenosine diphosphate-induced platelet aggregation in platelet-rich plasma, the prothrombin time, and the platelet count of platelet-rich plasma were measured. Four other healthy adults received placebos and participated in a double-blind study with those receiving Coumadin.Although administration of Coumadin caused a prolongation of the prothrombin time to 2 or 21/2 times the normal value, a decrease in the duration of platelet aggregation was not observed. In most individuals who received Coumadin an increase in the duration of platelet aggregation occurred. The effect of Coumadin on platelet aggregation was not consistently related to the prothrombin time or to the platelet count. In the placebo group there was a distinct relation between the duration of platelet aggregation and the platelet count in platelet-rich plasma.The mean increase in the duration of platelet aggregation when compared to the control value before medication with Coumadin was 37.7%. In the placebo group there was a mean increase of 8.4%. The difference between the two groups is significant (p <0.001). Increased duration of platelet aggregation also occurred in two individuals who received Coumadin over a period of 10 and 16 days respectively.

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