scholarly journals Assessment of the myocardial FDG-PET image quality with the use of maximal Standardized Uptake Value myocardial to background index. Application of the results in regard to semiquantitative assessment of myocardial viability with cardiac dedicated softwar

2017 ◽  
Vol 20 (2) ◽  
pp. 69-75
Author(s):  
Małgorzata Kobylecka ◽  
Tomasz Mazurek ◽  
Katarzyna Fronczewska-Wieniawska ◽  
Anna Fojt ◽  
Anna Słowikowska ◽  
...  
Keyword(s):  
Image Quality ◽  
Myocardial Viability ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Semiquantitative Assessment ◽  
Maximal Standardized Uptake Value ◽  
Background Index

scholarly journals Pulmonary Findings of [18F]FDG PET/CT Images on Asymptomatic COVID-19 Patients

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 839
Author(s):  
Tzu-Chuan Ho ◽  
Chin-Chuan Chang ◽  
Hung-Pin Chan ◽  
Ying-Fong Huang ◽  
Yi-Ming Arthur Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Fdg Uptake ◽  
Asymptomatic Patients ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Maximal Standardized Uptake Value ◽  
Fdg Pet Ct

During the coronavirus disease 2019 (COVID-19) pandemic, several case studies demonstrated that many asymptomatic patients with COVID-19 underwent fluorine-18 fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) examination for various indications. However, there is a lack of literature to characterize the pattern of [18F]FDG PET/CT imaging on asymptomatic COVID-19 patients. Therefore, a systematic review to analyze the pulmonary findings of [18F]FDG PET/CT on asymptomatic COVID-19 patients was conducted. This systematic review was performed under the guidelines of PRISMA. PubMed, Medline, and Web of Science were used to search for articles for this review. Articles with the key words: “asymptomatic”, “COVID-19”, “[18F]FDG PET/CT”, and “nuclear medicine” were searched for from 1 January 2020 to 20 May 2021. Thirty asymptomatic patients with COVID-19 were included in the eighteen articles. These patients had a mean age of 62.25 ± 14.85 years (male: 67.71 ± 12.00; female: 56.79 ± 15.81). [18F]FDG-avid lung lesions were found in 93.33% (28/30) of total patients. The major lesion was [18F]FDG-avid multiple ground-glass opacities (GGOs) in the peripheral or subpleural region in bilateral lungs, followed by the consolidation. The intensity of [18F]FDG uptake in multiple GGOs was 5.605 ± 2.914 (range from 2 to 12) for maximal standardized uptake value (SUVmax). [18F]FDG-avid thoracic lymph nodes (LN) were observed in 40% (12/40) of the patients. They mostly appeared in both mediastinal and hilar regions with an SUVmax of 5.8 ± 2.93 (range from 2.5 to 9.6). The [18F]FDG uptake was observed in multiple GGOs, as well as in the mediastinal and hilar LNs. These are common patterns in PET/CT of asymptomatic patients with COVID-19.

scholarly journals Revisiting the Marrow Metabolic Changes after Chemotherapy in Lymphoma: A Step towards Personalized Care

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Bingfeng Tang ◽  
Malaykumar M. Patel ◽  
Regina H. Wong ◽  
Daniel Wood ◽  
Christiana O. Wong ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Fdg Pet ◽  
Bone Marrow Involvement ◽  
Standardized Uptake Value ◽  
B Cell Lymphoma ◽  
Metabolic Changes ◽  
Personalized Care ◽  
Pet Ct ◽  
Maximal Standardized Uptake Value ◽  
Fdg Pet Ct

Purpose. The aims were to correlate individual marrow metabolic changes after chemotherapy with bone marrow biopsy (BMBx) for its potential value of personalized care in lymphoma. Methods. 26 patients (mean age, 58 ± 15 y; 13 female, 13 male) with follicular lymphoma or diffuse large B-cell lymphoma, referred to FDG-PET/CT imaging, who had BMBx from unilateral or bilateral iliac crest(s) before chemotherapy, were studied retrospectively. The maximal standardized uptake value (SUV) was measured from BMBx site over the same area on both initial staging and first available restaging FDG-PET/CT scan. Results. 35 BMBx sites in 26 patients were evaluated. 12 of 35 sites were BMBx positive with interval decrease in SUV in 11 of 12 sites (92%). The remaining 23 of 35 sites were BMBx negative with interval increase in SUV in 21 of 23 sites (91%). The correlation between SUV change over the BMBx site before and after chemotherapy and BMBx result was significant (P<0.0001). Conclusions. This preliminary result demonstrates a strong correlation between marrow metabolic changes (as determined by FDG PET) after chemotherapy and bone marrow involvement proven by biopsy. This may provide a retrospective means of personalized management of marrow involvement in deciding whether to deliver more extended therapy or closer followup of lymphoma patients.

scholarly journals Post-reconstruction enhancement of [18F]FDG PET images with a convolutional neural network

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
John Ly ◽  
David Minarik ◽  
Jonas Jögi ◽  
Per Wollmer ◽  
Elin Trägårdh
Keyword(s):  
Neural Network ◽  
Image Quality ◽  
Convolutional Neural Network ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Test Group ◽  
Acquisition Time ◽  
Positron Emission ◽  
Bed Position

Abstract Background The aim of the study was to develop and test an artificial intelligence (AI)-based method to improve the quality of [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) images. Methods A convolutional neural network (CNN) was trained by using pairs of excellent (acquisition time of 6 min/bed position) and standard (acquisition time of 1.5 min/bed position) or sub-standard (acquisition time of 1 min/bed position) images from 72 patients. A test group of 25 patients was used to validate the CNN qualitatively and quantitatively with 5 different image sets per patient: 4 min/bed position, 1.5 min/bed position with and without CNN, and 1 min/bed position with and without CNN. Results Difference in hotspot maximum or peak standardized uptake value between the standard 1.5 min and 1.5 min CNN images fell short of significance. Coefficient of variation, the noise level, was lower in the CNN-enhanced images compared with standard 1 min and 1.5 min images. Physicians ranked the 1.5 min CNN and the 4 min images highest regarding image quality (noise and contrast) and the standard 1 min images lowest. Conclusions AI can enhance [18F]FDG-PET images to reduce noise and increase contrast compared with standard images whilst keeping SUVmax/peak stability. There were significant differences in scoring between the 1.5 min and 1.5 min CNN image sets in all comparisons, the latter had higher scores in noise and contrast. Furthermore, difference in SUVmax and SUVpeak fell short of significance for that pair. The improved image quality can potentially be used either to provide better images to the nuclear medicine physicians or to reduce acquisition time/administered activity.

scholarly journals Long Term Results of a Multicenter Prospective Trial By the Lysa Group Evaluating the RiPAD+C Regimen (Combination of Rituximab, Bortezomib, Doxorubicin, Dexamethasone and Chlorambucil) As First-Line Therapy for Elderly Mantle Cell Lymphoma Patients (MCL): Prognostic Value of FDG-PET/CT

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 3070-3070 ◽  
Author(s):  
Julien Dubreuil ◽  
Roch Houot ◽  
Steven Le Gouill ◽  
Christiane Mounier ◽  
Stéphane Courby ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Research Funding ◽  
Standardized Uptake Value ◽  
Post Treatment ◽  
Prognostic Impact ◽  
Pet Ct ◽  
Mantle Cell ◽  
Maximal Standardized Uptake Value ◽  
Fdg Pet Ct

Abstract Background: Mantle cell lymphoma (MCL) is an aggressive lymphoma with variable 18Fluorine-Deoxyglucose (FDG) avidity. FDG - Positron Emission Tomography/Computed Tomography (FDG-PET/CT) is not yet recommended in MCL but many retrospective studies have underlined its prognostic impact either before any treatment or at interim or final time points of R-chemotherapy. The French LYSA/GOELAMS group published the results of a multicenter prospective phase II clinical trial evaluating the RiPAD + C front-line combination including one proteasome inhibitor (PS341-Velcade®) for elderly MCL patients(Houot, Le Gouill et al. 2012). The aim of the present study was to determine the prognostic value of FDG-PET/CT in this prospective cohort with a long follow up. Method: Patients between 65 and 80 years old were enrolled. They received 4 cycles of RiPAD+C regimen (every 35 days: Rituximab 375 mg/sqm D1, Velcade® 1.3 mg/sqm D1,4,8 and 11, Doxorubicin 9 mg/sqm D1 to D4, Dexamethasone 40 mg D1 to 4 and Chlorambucil 12 md D20 to D29) and 2 additional cyclesif they responded (IWR criteria). Three FDG-PET scans were performed: an initial pre-treatment, after 4 cycles (interim) and after 6 cycles (post-treatment). All available FDG-PET/CT were centrally reviewed by two experts, using visual international response assessment criteria proposed by IHP in Lymphoma and the Deauville five-point scale. The maximal standardized uptake value (SUVmax) and maximal standardized uptake value reduction (ΔSUVmax) of the most intense pathological area were measured. Results: From June 2007 to December 2008, 39 patients from 21 French centers were recruited. After 64 months follow-up for the 22 surviving patients, median overall survival (OS) has not been reached (the 3 year OS was 63,5%). Median progression free survival (PFS) is 22 months. Seventeen patients died either from lymphoma (n=13) or due to toxicity (n=4). Seventy-eight FDG-PET/CT were performed (31 initial FDG-PET/CT; 28 interim, 19 post-treatment), in 39 patients. We reviewed 24 initial FDG-PET/CT, 27 interim, and 16 post-treatment. By univariate analysis: neither initial, interim nor post-treatment FDG-PET/CT were predictive of OS or PFS. The ΔSUVmax (> 65% vs ≤ 65%, or > 50% vs ≤ 50%) was also not predictive for OS or PFS (p= 0.48 to 0.92). However high SUVmax (>10 vs ≤10) and clinical prognostic scores (MIPI or the Goelams index) correlated with OS (p=0.09, p= 0.054 and p=0.16, respectively). In a multivariate analysis patients with a high prognostic score at diagnosis combined with a positive post-treatment FDG-PET/CT had very poor OS compared to other profiles (high index with a negative post-treatment FDG-PET/CT or low-intermediate index with a negative or positive FDG-PET/CT). Conclusion: This is the first prospective study evaluating the prognostic impact of FDG-PET/CT in a cohort of homogeneously treated MCL patients with a long time of follow up. Neither initial, interim or post-treatment FDG-PET/CT were predictive of PFS or OS. However we confirm, as previously described in a retrospective analysis (Bodet-Milin, Touzeau et al. 2010), that both high SUVmax at initial FDG-PET/CT and the MIPI score were prognostic for OS. Interestingly, a negative post-treatment FDG-PET/CT seemed to erase the adverse prognostic significance of a high MIPI score before treatment. These observations warrant further confirmation in large prospective clinical trials. Disclosures Le Gouill: Roche: Consultancy; Janssen: Consultancy. Dartigeas:Roche: Consultancy. Tournilhac:mundipharma: Honoraria, Other, Research Funding; GSK: Honoraria, Other, Research Funding; Roche: Honoraria, Other, Research Funding. Gressin:MundiPharma: Other.

Maximal Standardized Uptake Value on FDG-PET Is Correlated With Cyclooxygenase-2 Expression in Patients With Lung Adenocarcinoma

2012 ◽  
Vol 93 (2) ◽  
pp. 398-403 ◽  
Author(s):  
Katsuhiko Shimizu ◽  
Yuji Hirami ◽  
Shinsuke Saisho ◽  
Takuro Yukawa ◽  
Ai Maeda ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Cyclooxygenase 2 ◽  
Maximal Standardized Uptake Value

Recent Chemotherapy Reduces the Sensitivity of [18F]Fluorodeoxyglucose Positron Emission Tomography in the Detection of Colorectal Metastases

2005 ◽  
Vol 23 (34) ◽  
pp. 8713-8716 ◽  
Author(s):  
Timothy Akhurst ◽  
Tara J. Kates ◽  
Madhu Mazumdar ◽  
Henry Yeung ◽  
Elyn R. Riedel ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Glycolytic Enzyme ◽  
Emission Tomography ◽  
Colorectal Metastases ◽  
Efficient Detection ◽  
Positron Emission ◽  
Pet Scanning ◽  
Maximal Standardized Uptake Value

Purpose [18F]2-fluoro-2-deoxyglucose (FDG) –positron emission tomography (PET) has become a useful tool in the assessment of patients with colorectal cancer. Patients often undergo chemotherapy as treatment for primary or metastatic colorectal malignancy. Because cytotoxic chemotherapy may decrease the cellular metabolic activity of tumor, we assessed the effects of chemotherapy on PET imaging. Patients and Methods This is a prospective study examining detection of hepatic colorectal metastases by FDG-PET as related to use of chemotherapy. Pathologic analysis of the liver resection specimens was used as gold standard. Results There was significantly decreased tumor FDG uptake (as measured by the maximal standardized uptake value) in patients treated preoperatively with chemotherapy, resulting in less efficient detection of cancerous lesions. One biologic basis of this change in accuracy of PET was a significant decrease in the activity of the key glycolytic enzyme hexokinase in tumors from patients treated with chemotherapy. Conclusion These results indicate that FDG-PET scanning should be interpreted in the context of concurrent cytotoxic therapy. FDG-PET scanning results may also be useful in assessment of response to such cytotoxic therapies.

scholarly journals FDG-PET/CT in intensive care patients with bloodstream infection

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Jordy P. Pijl ◽  
Mark Londema ◽  
Thomas C. Kwee ◽  
Maarten W. N. Nijsten ◽  
Riemer H. J. A. Slart ◽  
...  
Keyword(s):  
Intensive Care ◽  
Image Quality ◽  
Fdg Pet ◽  
Diagnostic Yield ◽  
Unknown Origin ◽  
Intensive Care Patients ◽  
Pet Ct ◽  
Infection Focus ◽  
Focus Of Infection ◽  
Fdg Pet Ct

Abstract Background 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is an advanced imaging technique that can be used to examine the whole body for an infection focus in a single examination in patients with bloodstream infection (BSI) of unknown origin. However, literature on the use of this technique in intensive care patients is scarce. The purpose of this study was to evaluate the diagnostic yield of FDG-PET/CT in intensive care patients with BSI. Methods In this retrospective cohort study, all intensive care patients from our Dutch university medical center who had culture-proven BSI between 2010 and 2020 and underwent FDG-PET/CT to find the focus of infection were included. Diagnostic performance was calculated and logistic regression analysis was performed to evaluate the association between FDG-PET/CT outcome and C-reactive protein level (CRP), leukocyte count, duration of antibiotic treatment, duration of ICU stay, quality of FDG-PET/CT, and dependency on mechanical ventilation. In addition, the impact of FDG-PET/CT on clinical treatment was evaluated. Results 30 intensive care patients with BSI were included. In 21 patients, an infection focus was found on FDG-PET/CT which led to changes in clinical management in 14 patients. FDG-PET/CT achieved a sensitivity of 90.9% and specificity of 87.5% for identifying the focus of infection. Poor quality of the FDG-PET images significantly decreased the likelihood of finding an infection focus as compared to reasonable or good image quality (OR 0.16, P = 0.034). No other variables were significantly associated with FDG-PET/CT outcome. No adverse events during the FDG-PET/CT procedure were reported. Conclusion FDG-PET/CT has a high diagnostic yield for detecting the infection focus in patients with BSI admitted to intensive care. Poor PET image quality was significantly associated with a decreased likelihood of finding the infection focus in patients with BSI. This could be improved by adequate dietary preparation and cessation of intravenous glucose and glucose-regulating drugs. Recent advances in PET/CT technology enable higher image quality with shorter imaging time and may contribute to routinely performing FDG-PET/CT in intensive care patients with BSI of unknown origin.

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