scholarly journals The influence of non-radioactive iodine (127I) on the outcome of radioiodine (131I) therapy in patients with Graves’ disease and toxic nodular goitre

2011 ◽  
Vol 14 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Franciszek Rogowski ◽  
Saeid Abdelrazek ◽  
Piotr Szumowski ◽  
Anna Zonenberg ◽  
Adam Parfienczyk ◽  
...  
Keyword(s):  
Radioactive Iodine ◽  
131I Therapy ◽  
Graves Disease ◽  
Nodular Goitre ◽  
Toxic Nodular Goitre

FURTHER STUDIES ON THE RATE OF DISAPPEARANCE OF LABELLED THYROXINE FROM THE INTRAVASCULAR COMPARTMENT OF MAN, WITH REFERENCE TO THE ROLE OF THYROXINE BINDING PROTEINS

1967 ◽  
Vol 55 (3) ◽  
pp. 497-521 ◽  
Author(s):  
Brian R. Webster ◽  
Amy Britton ◽  
Robert Volpé ◽  
Calvin Ezrin
Keyword(s):  
Binding Sites ◽  
Radioactive Iodine ◽  
Binding Capacity ◽  
Normal Subjects ◽  
Graves Disease ◽  
List Type ◽  
Half Time ◽  
Nodular Goitre ◽  
Toxic Nodular Goitre

ABSTRACT The disappearance of an intravenously injected tracer dose of 131I-labelled L-thyroxine from the circulation has been followed for 70 minutes. We have confirmed that the most significant separation between euthyroid subjects and patients with hyperthyroidism or myxoedema is given by the single exponential slope of the regression of blood radioactivity occurring between 20 and 50 minutes after T4* injection. This slope is referred to as the acute T4* half-time. When there is no alteration in total TBG the acute T4* half-time is closely related to the plasma BEI concentration. Increase in the latter due to Graves' disease, toxic nodular goitre, or exogenous administration of thyroxine or desiccated thyroid, results in a comparable acceleration in the acute T4* half-time compared to the value in euthyroid control subjects. Conversely patients with a low BEI due to primary or radioactive iodine induced myxoedema all have a significantly slow acute T4* half-time compared to normal subjects. There was no specific abnormality in the handling of thyroxine by patients with Graves' disease in contrast to the earlier findings of Lennon et al. (1961). Hypermetabolism per se does not affect the acute T4* half-time. The administration of pharmacological doses of triiodothyronine, unlike similar doses of thyroxine, failed to affect the acute T4* half-time. The acute T4* half-time is consistently related in an inverse manner to the concentration of unsaturated thyroxine-binding sites in association with TBG. These data show no such correlation between TBPA binding and the acute T4 half-time. Synthetic oestrogen, by increasing the unsaturated thyroxine-binding capacity of TBG, produces a profound slowing of the acute T4* halftime.

Antithyroid drugs as a factor influencing the outcome of radioiodine therapy in Graves' disease and toxic nodular goitre?

2001 ◽  
Vol 28 (9) ◽  
pp. 1360-1364 ◽  
Author(s):  
C. Körber ◽  
P. Schneider ◽  
N. Körber-Hafner ◽  
H. Hänscheid ◽  
C. Reiners
Keyword(s):  
Radioiodine Therapy ◽  
Antithyroid Drugs ◽  
Graves Disease ◽  
Nodular Goitre ◽  
Toxic Nodular Goitre

Appearance of thyroid stimulating antibody and Graves' disease after radioiodine therapy for toxic nodular goitre

1994 ◽  
Vol 40 (6) ◽  
pp. 803-806 ◽  
Author(s):  
Luca Chiovato ◽  
Ferruccio Santini ◽  
Paolo Vitti ◽  
Giovanna Bendinelli ◽  
Aldo Pinchera
Keyword(s):  
Radioiodine Therapy ◽  
Graves Disease ◽  
Nodular Goitre ◽  
Thyroid Stimulating Antibody ◽  
Toxic Nodular Goitre

scholarly journals Incidence of hyperthyroidism in Stockholm, Sweden, 2003–2005.

2008 ◽  
Vol 158 (6) ◽  
pp. 823-827 ◽  
Author(s):  
Mirna Abraham-Nordling ◽  
Ove Törring ◽  
Mikael Lantz ◽  
Bengt Hallengren ◽  
Hans Ohrling ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Adult Population ◽  
Graves Disease ◽  
Multinodular Goitre ◽  
Stockholm County ◽  
Toxic Adenoma ◽  
Nodular Goitre ◽  
Total Incidence ◽  
First Time ◽  
Toxic Nodular Goitre

ObjectivesTo investigate the incidence of hyperthyroidism in Stockholm County, in those patients who were diagnosed with hyperthyroidism for the first time during the years 2003–2005.DesignAll new cases of hyperthyroidism ≥18 years of age were prospectively registered to calculate the total incidence of hyperthyroidism, as well as the incidence of the subgroups: Graves' disease (GD), toxic multinodular goitre and solitary toxic adenoma (STA). Eight specialized units/hospitals in Stockholm County participated in the registration. The participating physicians were all specialists in medical endocrinology, oncology, nuclear medicine or surgery.ResultsDuring a 3-year period, 1431 new patients of hyperthyroidism were diagnosed in a well-defined adult population (>18 years of age) of in average 1 457 036 inhabitants. This corresponds to a mean annual incidence of hyperthyroidism of 32.7/100 000. The incidence of GD was 24.5/100 000 per year, toxic nodular goitre was 3.3/100 000 per year and STA was 4.9/100 000 per year.ConclusionsThe total incidence of hyperthyroidism in Stockholm County was found to be 32.7/100 000 per year, of which 75% had GD. There were a higher percentage of smokers among the patients with hyperthyroidism compared with the overall population in Stockholm, but no difference in the frequency of smoking between patients with GD and toxic nodular goitre.

Relationship between the number and impact of stressful life events and the onset of Graves' disease and toxic nodular goitre★

2001 ◽  
Vol 55 (1) ◽  
pp. 15-19 ◽  
Author(s):  
A. Matos-Santos ◽  
E. Lacerda Nobre ◽  
J. Garcia E Costa ◽  
P. J. Nogueira ◽  
A. Macedo ◽  
...  
Keyword(s):  
Life Events ◽  
Stressful Life Events ◽  
Stressful Life ◽  
Graves Disease ◽  
Nodular Goitre ◽  
Toxic Nodular Goitre

LONG-ACTING THYROID STIMULATOR (LATS) IN TOXIC NODULAR GOITRE, TOXIC ADENOMA AND GRAVES' DISEASE

1969 ◽  
Vol 62 (2) ◽  
pp. 199-209 ◽  
Author(s):  
B.-A. Lamberg ◽  
A. Gordin ◽  
M. Viherkoski ◽  
G. Kvist
Keyword(s):  
Present Series ◽  
Surrounding Tissue ◽  
Graves Disease ◽  
List Type ◽  
Multinodular Goitre ◽  
Toxic Adenoma ◽  
Nodular Goitre ◽  
Group 2 ◽  
Long Acting ◽  
Toxic Nodular Goitre

ABSTRACT The long-acting thyroid stimulator (LATS) was determined by means of the McKenzie assay in 68 patients with hyperthyroidism. The patients were classified into the following groups: Group 1. Graves' disease (diffuse goitre with hyperthyroidism with or without exophthalmos). Of the 35 patients tested 25 (71 %) were LATS-positive. Group 2. Graves' disease with nodular goitre (nodular goitre with hyperthyroidism and with exophthalmos). The present series includes only 4 such patients, although this combination is by no means uncommon in Finland. Two of the patients were LATS-positive. It has been suggested that these patients represent Graves' disease superimposed upon endemic nodular goitre. Group 3. Toxic nodular goitre. The present series comprises 23 patients with toxic multinodular goitre, of whom 10 (44%) were LATS-positive. In view of the findings on thyroid palpation, on thyroid scintigraphy, the presence or absence of LATS in the blood and some other criteria, these patients can be divided into two categories, (a) one with Graves' disease superimposed upon nodular goitre of endemic origin (see group 2) and (b) the other with classical multinodular goitre. Analysis of the scintigrams showed that in some patients (with either exophthalmos or LATS in the blood and nodular goitre = Graves' disease + nodular goitre) it was not the nodules that were activated but the paranodular tissue, a finding which gave a scintigram typical of patients with classical Graves' disease. In some LATS-positive cases, however, some nodules were also activated to the same extent. The difference between these scintigrams and those typical of classical multinodular goitre is particularly stressed since in Finland »toxic nodular goitre« is the prevailing type of hyperthyroidism. Group 4. Single toxic adenoma. Two patients out of 6 were LATS-positive. This is in contrast to the findings of other authors according to which LATS has never been found in patients with toxic adenoma. A hypothesis is put forward that in these patients subclinical Graves' disease (LATS in the blood) coincided with a primarily autonomous, hyperactive but not necessarily toxic single thyroid adenoma, which was more susceptible to the stimulating activity of LATS than the surrounding tissue.

Intensity of Depressive Symptoms and Disorders of Working Memory and Executive Functions in Hyperthyroidism in the Course of Graves’ Disease and Toxic Nodular Goitre

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
K. Jabłkowska ◽  
K. Nowakowska ◽  
G. Adamiak ◽  
A. Borkowska
Keyword(s):  
Working Memory ◽  
Executive Functions ◽  
Wisconsin Card Sorting Test ◽  
Thyroid Diseases ◽  
Control Group ◽  
Depression Symptoms ◽  
Graves Disease ◽  
Nodular Goitre ◽  
Increased Risk ◽  
Toxic Nodular Goitre

Current data show an association between thyroid diseases and cognitive dysfunction and depression. Depression may affect the clinical picture and the course of thyroid diseases, while also certain correlations are seen between depression and an increased risk of the incidence of these diseases.The aim of this study was tracing associations among depression and hyperthyroidism in the course of Graves’ disease and toxic nodular goitre in particular stages of the disease and frontal cognitive function.Eighty persons (63 females and 17 males) with diagnosed hyperthyroidism, their age ranging between 18 and 55 years, were qualified into the study, fifty (50) of them with Graves’ disease and thirty (30) with toxic nodular goitre.Following performed hormonal evaluations, patients with overt or subclinical hyperthyroidism were identified, together with patients in euthyroidism.The control group included thirty-one (31) healthy volunteers, matched with the study group, regarding their age, sex and education.In the evaluation of working memory and executive functions, the Wisconsin Card Sorting Test (WCST) was used, while Beck Depression Inventory (BDI) was applied to determine the degree of depression symptoms.The obtained results showed impairment of WCST performance in patients with Graves’ disease and with toxic nodular goitre. Any significant associations between the degree of depression symptoms and the efficiency of either working memory or executive functions were found.Acknowledgements:This research was supported by grant 502-16-683 Medical University of Lodz.

Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos

1981 ◽  
Vol 96 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Ulla Feldt Rasmussen ◽  
Axel Kemp ◽  
Karine Bech ◽  
Stig Nistrup Madsen ◽  
John Date
Keyword(s):  
Eye Disease ◽  
Graves Disease ◽  
Thyroid Autoantibodies ◽  
Serum Concentrations ◽  
Serum Thyroglobulin ◽  
Nodular Goitre ◽  
Thyroglobulin Antibodies ◽  
Thyroid Stimulating Antibodies ◽  
Persistent Elevation ◽  
Toxic Nodular Goitre

Abstract. Serum concentrations of thyroglobulin, its antibody, and thyroid stimulating antibodies were studied in 32 patients referred to a department of eye-diseases for exophthalmos. Twenty-three of the patients were or had been medically treated for Graves' disease, one had toxic nodular goitre, one subclinical myxoedema, three euthyroid exophthalmos and four were shown to have non-endocrine eye-disease. In patients with medically treated Graves' disease serum thyroglobulin was significantly elevated (P < 0.02), the still toxic patients accounting for the highest values. Both thyroid stimulating and thyroglobulin antibodies were detectable in 4 of 18 patients. The rest of the patients had normal concentrations of thyroglobulin and undetectable thyroid stimulating antibodies, but 3 patients had measurable thyroglobulin antibodies. In Graves' patients there was no correlation between serum concentrations of thyroid stimulating antibodies and thyroglobulin, and no clear difference between the frequency of thyroid stimulating or thyroglobulin antibodies in the patients with persistent elevation of circulating thyroid hormones and those remaining euthyroid. A relation between the thyroid autoantibodies, thyroglobulin and the thyroid hormonal level or severity of the exophthalmic state could not be demonstrated. It is suggested that hyperthyroidism and exophthalmos are separate disorders, and immunological phenomena probably involved in the pathogenesis of exophthalmos associated with Graves' disease appear to be reflected only locally.

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