scholarly journals Bilateral synchronous breast cancer developed as metachronous malignancy after therapy of other primaries

2018 ◽  
Vol 89 (5) ◽  
pp. 235-239
Author(s):  
Michał Kurzyński ◽  
Jerzy Mituś ◽  
Marta Kołodziej-Rzepa ◽  
Beata Sas-Korczyńska
Keyword(s):  
Breast Cancer ◽  
Synchronous Breast Cancer

Primary Extra-Uterine Endometrial Stromal Sarcoma and Synchronous Breast Cancer: A Double Whammy: A Case report

2021 ◽  
Author(s):  
Pavneet Kohli ◽  
Prasanth Penumadu ◽  
Neelesh Srivastava ◽  
Bheemanathi Hanuman Srinivas ◽  
Vidyalakshmi Rangarajan
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Endometrial Stromal Sarcoma ◽  
Stromal Sarcoma ◽  
Synchronous Breast Cancer

scholarly journals Impact of Pre-Operative Breast Magnetic Resonance Imaging (MRI) on Contralateral Synchronous and Metachronous Breast Cancer Detection- A Case Control Comparison Study With Mean Follow-Up of 102 Months.

2021 ◽  
Author(s):  
Wen-Pei Wu ◽  
Chih-Yu Chen ◽  
Chih-Wei Lee ◽  
Hwa-Koon Wu ◽  
Shou-Tung Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Detection ◽  
Contralateral Breast Cancer ◽  
Breast Mri ◽  
Contralateral Breast ◽  
Conventional Imaging ◽  
Metachronous Breast Cancer ◽  
Group B ◽  
Synchronous Breast Cancer

Abstract Background: Women with unilateral breast cancer are at an increased risk for the development of contralateral breast cancers. We hypothesis that combined breast MRI would detect more contralateral synchronous breast cancer than conventional imaging alone, and resulted in less contralateral metachronous breast cancer during follow-up. Methods: In this case control analysis, we retrospectively collected two groups of patients for evaluating the effectiveness and value of adding pre-operative breast MRI to conventional breast images (mammography and sonography) for detection of contralateral synchronous breast cancer. The new metachronous contralateral breast cancer diagnosed during follow-up was prospectively evaluated and compared. Results: Group A (n=733) comprised patients who underwent conventional preoperative imaging and group B (n=735) combined with MRI were enrolled and compared. Seventy (9.5%) of the group B patients were found to have contralateral lesions detected by breast MRI, and 65.7% of these lesions only visible with MRI. The positive predictive value of breast MRI detected contralateral lesions was 48.8%. With the addition of breast MRI to conventional imaging studies, more surgical excisions were performed in contralateral breasts (6% (44/735) versus 1.4% (10/733), P< 0.01), more synchronous contralateral breast cancer detected (2.9% (21/735) versus 1.1% (8/733), P=0.02), and resulted in numerical less (2.2% (16/714) versus 3% (22/725), p=0.3) metachronous contralateral breast cancer during a mean follow-up of 102 months. Conclusions: Combining pre-operative breast MRI evaluation resulted in an increase of contralateral synchronous breast cancer detection, and a numerical less subsequent contralateral metachronous breast cancer occurrence compared to conventional imaging alone.

scholarly journals Synchronous Breast Cancer: Phenotypic Similarities on MRI

2019 ◽  
Vol 51 (6) ◽  
pp. 1858-1867 ◽  
Author(s):  
Hui Wang ◽  
Bas H.M. Velden ◽  
Hui Shan M. Chan ◽  
Claudette E. Loo ◽  
Max A. Viergever ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Synchronous Breast Cancer

Incidence and Prognosis of Synchronous and Metachronous Bilateral Breast Cancer

2007 ◽  
Vol 25 (27) ◽  
pp. 4210-4216 ◽  
Author(s):  
Mikael Hartman ◽  
Kamila Czene ◽  
Marie Reilly ◽  
Jan Adolfsson ◽  
Jonas Bergh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Bilateral Breast Cancer ◽  
Metachronous Cancer ◽  
Unilateral Breast Cancer ◽  
Dual Effect ◽  
Prognostic Features ◽  
Incidence Trends ◽  
Incidence And Mortality ◽  
Synchronous Breast Cancer

Purpose Because the incidence of breast cancer is increasing and prognosis is improving, a growing number of women are at risk of developing bilateral disease. Little is known, however, about incidence trends and prognostic features of bilateral breast cancer. Patients and Methods Among 123,757 women with a primary breast cancer diagnosed in Sweden from 1970 to 2000, a total of 6,550 developed bilateral breast cancer. We separated synchronous (diagnosed within 3 months after a first breast cancer) and metachronous bilateral cancer, and analyzed incidence and mortality rates of breast cancer using Poisson regression models. Results The incidence of synchronous breast cancer increased by age and by 40% during the 1970s, whereas the incidence of metachronous cancer decreased by age and by approximately 30% since the early 1980s, most likely due to increasing use of adjuvant therapy. Women who developed bilateral cancer within 5 years and at age younger than 50 years were 3.9 times (95% CI, 3.5 to 4.5) more likely to die as a result of breast cancer than women with unilateral cancer. Women with a bilateral cancer diagnosed more than 10 years after the first cancer had a prognosis similar to that of a unilateral breast cancer. Adjuvant chemotherapy of primary cancer is a predictor of poor survival after diagnosis of early metachronous cancers. Conclusion We found profound differences in the incidence trends and prognostic outlook between synchronous and metachronous bilateral breast cancer diagnosed at different ages. Adjuvant chemotherapy therapy has a dual effect on metachronous cancer: it reduces the risk, while at the same time it seems to worsen the prognosis.

Trends in synchronous invasive ductal carcinomas of the breast: A SEER database analysis.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e13081-e13081
Author(s):  
Rutika Jitesh Mehta ◽  
Adrienne Groman ◽  
Rohit K. Jain ◽  
Ellis Glenn Levine
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Cancer Diagnosis ◽  
Breast Cancer Diagnosis ◽  
Incidence Rates ◽  
Age Group ◽  
Breast Cancers ◽  
Seer Database ◽  
Younger Women ◽  
Synchronous Breast Cancer

e13081 Background: Synchronous breast cancers are uncommon and account for around 2% of all breast cancer diagnosis. Lobular histology is considered a risk factor for synchronous breast cancers. We sought to study the trends in synchronous breast cancer of ductal histology and influence of age by interrogating the SEER database. Methods: The SEER Research data 1973-2013 was interrogated for synchronous infiltrating ductal carcinoma diagnosis (2 diagnosis within 6 months of each other). Overall survival (OS), the primary endpoint, was defined as the time (in months) from diagnosis to death from any cause. Univariate proportional hazards modeling results were used to assess the effect of age, race and stage on overall survival. All associations were considered statistically significant at an alpha error < 0.01. All analyses were performed using SAS version 9.4. Results: 1469 cases were identified. Data was categorized by age group: ≤ 65 years or > 65 years. 60% were 65 years or younger. 85% were Caucasians, 9.6% African Americans and 5.2% others. Younger women (≤ 65 years) had a statistically higher proportion of Stage III/IV breast cancer diagnosis as compared to older women (33.4% vs 25.2%; p = 0.002). The incidence rate of synchronous breast cancers has been rising since 1973, more pronounced in the older age group. Incidence rates overall have risen from 0.09/100,000 persons in 1973-1980 to 0.29/100,000 persons in 2001-2013 (p < 0.001). Incidence rates for synchronous breast cancer in women > 65 years has increased from 0.30/100,000 persons in 1973-1980 to 1.03/100,000 persons in 2001-2013. The adjusted OS among older women is significantly worse than that of younger women (HR 1.05; 95% CI 1.04-1.05; p < 0.001). Conclusions: Better imaging techniques and breast cancer screening guidelines have likely improved breast cancer detection rates thus leading to a rise in the incidence of synchronous breast cancers. It can be speculated that underlying medical problems and advanced age result in more morbidity and subsequent mortality in older women with standard treatment. The finding of more advanced disease among younger women deserves scrutiny as to cause.

scholarly journals Synchronous breast cancer and alveolar rhabdomyosarcoma bone marrow metastases

2018 ◽  
Vol 13 (3) ◽  
pp. 680-684 ◽  
Author(s):  
Ami Shah ◽  
Jonathon Weber ◽  
Angelique Floerke ◽  
Luis Blanco ◽  
Cesar Santa-Maria ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Alveolar Rhabdomyosarcoma ◽  
Bone Marrow Metastases ◽  
Synchronous Breast Cancer

scholarly journals A Clinical Case Study of Synchronous Breast Cancer

2021 ◽  
Vol 28 (3) ◽  
pp. 329-332
Author(s):  
Mihai MEHEDINTU-IONESCU ◽  
◽  
Stefan-Andrei COMAN ◽  
Horia-Alexandru TOADER ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Clinical Case ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Clinical Case Study ◽  
The Right ◽  
Synchronous Breast Cancer

The following article represents a clinical case study of a synchronous breast cancer in a 47 year old woman with no prior significant comorbidities.Up to 10% of all breast cancers can be synchronous (usually found with the help of breast MRI). The occurrence of bilaterally is considerable with invasive lobular carcinoma. The patient observed after self-palpating her breast a nodule in the infero-external quadrant of the right breast. During almost 4 months the patient underwent punch biopsy of the right breast, lumpectomy and finally double mastectomy with immediate reconstruction using Mentor implants and AMD. The histopathological result showed ductal carcinoma in situ in the right breast and lobular carcinoma in situ in both breasts. Postoperatively the patient is free of cancer, but under clinical and imagistic surveillance.

Bilateral Synchronous Breast Cancer: Imaging Findings of Mammography, US, MRI and FDG-PET

2011 ◽  
Vol 37 (8) ◽  
pp. S98-S99
Author(s):  
H.A. Jung ◽  
J.H. Lee ◽  
H. Kwon ◽  
D. Ha ◽  
M. Kang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fdg Pet ◽  
Cancer Imaging ◽  
Imaging Findings ◽  
Breast Cancer Imaging ◽  
Synchronous Breast Cancer
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