scholarly journals The role of early determination of β-human chorionic gonadotropin levels in predicting the success of single-dose methotrexate treatment in ectopic pregnancy

2016 ◽  
Vol 87 (7) ◽  
pp. 484-487 ◽  
Author(s):  
Handan Çelik ◽  
Miğraci Tosun ◽  
Yüksel Işık ◽  
Bahattin Avcı
Keyword(s):  
Single Dose ◽  
Ectopic Pregnancy ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Dose Methotrexate ◽  
Methotrexate Treatment

scholarly journals Beta-Human Chorionic Gonadotropin and Uterine Artery Doppler Measurements for the Prediction of Success of Single Dose Methotrexate Treatment in Tubal Ectopic Pregnancies

2016 ◽  
Vol 22 (1) ◽  
Author(s):  
Kılıç Çiğdem ◽  
Mehmet Metin Altay ◽  
Tuğba Kınay ◽  
Metin Kaplan ◽  
Serap Fırtına Tuncer ◽  
...  
Keyword(s):  
Single Dose ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Multiple Dose ◽  
Uterine Artery ◽  
Methotrexate Therapy ◽  
Uterine Artery Doppler ◽  
Dose Methotrexate ◽  
Methotrexate Treatment ◽  
Β Hcg

<p>Objectives: To evaluate the impact of the uterine artery Doppler values and the change of β-Human chorionic gonadotropin (β-HCG) levels from day 0 to day 4 for prediction of the success of single dose methotrexate treatment in tubal pregnancy cases. <br />Study Design: 50 patients with tubal pregnancy were included the prospective study. The location and size of ectopic pregnancy, bilateral uterine artery pulsed color doppler imaging was examined by ultrasonography and serum β-HCG levels were measured on day 0, 4, 7 of treatment. Success was defined as decrease of β-HCG level &lt;10 mIU/mL with single dose methotrexate treatment. Multiple dose methotrexate treatment and surgical treatment were considered as treatment failure.<br />Results: 32 patients (64%) treated with single dose methotrexate, 14 patients (28%) treated with multiple dose methotrexate, and 4 patients (8%) treated with surgery. In the group with β-HCG level decrease &gt; 15.04% on day 4, single-dose methotrexate therapy were 3.82 times more successful than the group without &gt; 15.04% β-HCG decrease. However, no significant alteration of uterine artery Doppler measurements was determined on the same days.<br />Conclusion: Reduction rate in the β-HCG level on day 4 of treatment can be used in determination the success of single-dose methotrexate therapy. <br /><br /></p>

The efficency of single dose methotrexate treatment with ectopic pregnancy

2011 ◽  
Vol 26 (4) ◽  
pp. 148-151
Author(s):  
Neval Yaman Goruk ◽  
Necdet Suer ◽  
Fatma Cetin Pelit ◽  
Abdulkadir Turgut
Keyword(s):  
Single Dose ◽  
Ectopic Pregnancy ◽  
Dose Methotrexate ◽  
Methotrexate Treatment
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