scholarly journals International Cardiovascular Research Meeting — Abstracts

2015 ◽  
Vol 3 (3) ◽  
pp. 125-138
Author(s):  
Folia Medica Copernicana
2013 ◽  
pp. 16-17
Author(s):  
David Grieve ◽  
Barbara McDermott ◽  
Emma Robinson ◽  
Melanie Madhani

2020 ◽  
Vol 42 (6) ◽  
pp. 44-45

As the year winds to a close, we take a moment to look at some of the recent news from the publishing arm of the Biochemical Society, Portland Press. We have created several interesting collections for our journals, grouping articles together in one place for easy reading, which are available online now. There is also a brief look at the award winners of the oral presentations from the 2020 European Council for Cardiovascular Research Meeting. We are pleased to announce that our two new journals (both launched in 2017) achieved significant milestones in 2020. Neuronal Signaling is now indexed in PubMed Central, and Emerging Topics in Life Sciences (published on behalf of the Biochemical Society and the Royal Society of Biology) is now indexed in PubMed. Neuronal Signaling provides an interdisciplinary home for neuroscience covering all aspects of in vitro and in vivo signalling from cell to brain in health and disease. Why not consider submitting your research for consideration? We welcome pre-submission enquiries (email [email protected]).


Author(s):  
B. M. Culbertson ◽  
M. L. Devinev ◽  
E. C. Kao

The service performance of current dental composite materials, such as anterior and posterior restoratives and/or veneer cements, needs to be improved. As part of a comprehensive effort to find ways to improve such materials, we have launched a broad spectrum study of the physicochemical and mechanical properties of photopolymerizable or visible light cured (VLC) dental composites. The commercially available VLC materials being studied are shown in Table 1. A generic or neat resin VLC system is also being characterized by SEM and TEM, to more fully understand formulation variables and their effects on properties.At a recent dental research meeting, we reported on the differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) characterization of the materials in Table 1. It was shown by DSC and DMA that the materials are substantially undercured by commonly used VLC techniques. Post curing in an oral cavity or a dry environment at 37 to 50°C for 7 or more hours substantially enhances the cure of the materials.


2020 ◽  
Vol 134 (17) ◽  
pp. 2243-2262
Author(s):  
Danlin Liu ◽  
Gavin Richardson ◽  
Fehmi M. Benli ◽  
Catherine Park ◽  
João V. de Souza ◽  
...  

Abstract In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.


2012 ◽  
Vol 26 (4) ◽  
pp. 178-203 ◽  
Author(s):  
Francesco Riganello ◽  
Sergio Garbarino ◽  
Walter G. Sannita

Measures of heart rate variability (HRV) are major indices of the sympathovagal balance in cardiovascular research. These measures are thought to reflect complex patterns of brain activation as well and HRV is now emerging as a descriptor thought to provide information on the nervous system organization of homeostatic responses in accordance with the situational requirements. Current models of integration equate HRV to the affective states as parallel outputs of the central autonomic network, with HRV reflecting its organization of affective, physiological, “cognitive,” and behavioral elements into a homeostatic response. Clinical application is in the study of patients with psychiatric disorders, traumatic brain injury, impaired emotion-specific processing, personality, and communication disorders. HRV responses to highly emotional sensory inputs have been identified in subjects in vegetative state and in healthy or brain injured subjects processing complex sensory stimuli. In this respect, HRV measurements can provide additional information on the brain functional setup in the severely brain damaged and would provide researchers with a suitable approach in the absence of conscious behavior or whenever complex experimental conditions and data collection are impracticable, as it is the case, for example, in intensive care units.


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