scholarly journals The morphology and application of stem cells in digestive system surgery

2020 ◽  
Author(s):  
M. Pucułek ◽  
J. Baj ◽  
P. Portincasa ◽  
M. Sitarz ◽  
C. Grochowski ◽  
...  
Keyword(s):  
Stem Cells ◽  
Digestive System ◽  
Digestive System Surgery

scholarly journals Cancer Stem Cells of the Digestive System

2014 ◽  
Vol 44 (12) ◽  
pp. 1141-1149 ◽  
Author(s):  
H. S. Colvin ◽  
N. Nishida ◽  
J. Koseki ◽  
M. Konno ◽  
K. Kawamoto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Digestive System

scholarly journals Drug-Induced Injury of the Gastrointestinal System and Methods for Its Correction (A Review)

Biomeditsina ◽  
2020 ◽  
Vol 16 (3) ◽  
pp. 14-34
Author(s):  
R. A. Klesov ◽  
N. N. Karkischenko ◽  
O. I. Stepanova ◽  
E. L. Matveyenko
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Digestive System ◽  
Organ Protection ◽  
Drug Induced ◽  
Development Of Resistance ◽  
Intestinal Immune System ◽  
The Russian Federation ◽  
Significant Attention

Common complications of pharmacotherapy involve damage to the gastrointestinal tract, development of resistance to traditional therapy, destruction of the intramural nervous system of the intestines, changes in the opportunistic microflora, dysfunctions of the intestinal immune system. According to WHO experts, diseases of the digestive system are expected to become one of the leading causes of disability. This paper reviews current publications on drug-induced injuries of the gastrointestinal tract, including those induced by drugs aimed at preventing such conditions. Side effects of NSAIDs, glucocorticoids, minerals, neuroleptics, antibiotics, cytostatics, saluretics, anticoagulants, contraceptives, as well as enemas, suppositories and other drugs are described. Published review papers paid significant attention to drug-induced injuries of the stomach; however, there is a lack of data on drug-induced lesions of the gastrointestinal tract. This paper aims to brigde this gap. New approaches to correction and organ protection are described. The epigenetic issues related to the pluripotency of stem cells are considered. In the Russian Federation, a regulatory framework was created to regulate all the fundamental processes associated with the production and use of biomedical cell products and biotechnologies.

BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract

2020 ◽  
Vol 82 (1) ◽  
pp. 251-273 ◽  
Author(s):  
Yongchun Zhang ◽  
Jianwen Que
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Digestive System ◽  
Bmp Signaling ◽  
Gi Tract ◽  
Multiple Organs ◽  
Morphogenetic Protein ◽  
New Findings ◽  
Bmp Pathway ◽  
Disease Initiation

The bone morphogenetic protein (BMP) pathway is essential for the morphogenesis of multiple organs in the digestive system. Abnormal BMP signaling has also been associated with disease initiation and progression in the gastrointestinal (GI) tract and associated organs. Recent studies using animal models, tissue organoids, and human pluripotent stem cells have significantly expanded our understanding of the roles played by BMPs in the development and homeostasis of GI organs. It is clear that BMP signaling regulates GI function and disease progression that involve stem/progenitor cells and inflammation in a tissue-specific manner. In this review we discuss these new findings with a focus on the esophagus, stomach, and intestine.

scholarly journals Evaluation of underreported surgical site infection evidenced by post-discharge surveillance

2007 ◽  
Vol 15 (5) ◽  
pp. 992-997 ◽  
Author(s):  
Adriana Cristina de Oliveira ◽  
Daclé Vilma Carvalho
Keyword(s):  
Prospective Study ◽  
Surgical Site Infection ◽  
Digestive System ◽  
Site Infection ◽  
Post Discharge ◽  
General Hospitals ◽  
Infection Incidence ◽  
Surgical Site Infection Incidence ◽  
Digestive System Surgery ◽  
The Impact

The Surgical Site Infection (SSI) has been pointed as one of the most important infection sites. This study aimed to determine the surgical site infection incidence during hospitalization and the impact of notification after discharge through two methods. This prospective study was carried out in the digestive system surgery service (DSS) of two general hospitals of São Paulo, in the period from August, 2001 to March, 2002. Incidence levels of 6.7% and 4.5% were notified in the institutions A and B respectively. The incidence of SSI after discharge in the institution A was 27% and 13.4% in the institution B. Surveillance after discharge evidenced global rates of 33.7% and 17.9% for institutions A and B respectively. The rates of infection increased 5.02 and 3.98 times respectively in institutions A and B.

scholarly journals Nanomedicine strategies for sustained, controlled, and targeted treatment of cancer stem cells of the digestive system

2016 ◽  
Vol 8 (10) ◽  
pp. 735 ◽  
Author(s):  
Fang-Yuan Xie ◽  
Wei-Heng Xu ◽  
Chuan Yin ◽  
Guo-Qing Zhang ◽  
Yan-Qiang Zhong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Digestive System ◽  
Targeted Treatment

The Role of PGC-1α in Digestive System Malignant Tumours

2020 ◽  
Vol 20 (3) ◽  
pp. 276-285
Author(s):  
Qiushuang Zhang ◽  
Wei Chen ◽  
Chao Xie ◽  
Xiaoshuo Dai ◽  
Junfen Ma ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Digestive System ◽  
Research Progress ◽  
Malignant Tumours ◽  
Mitochondrial Energy Metabolism ◽  
Pancreatic Cancer Cells ◽  
Incidence And Mortality ◽  
Pancreatic Cancer Stem Cells

Background: Cancer is increasingly becoming the leading cause of death in many countries, and malignant tumours of the digestive system account for majority of cancer incidence and mortality cases. Metabolism has been identified as a core hallmark of cancer. Peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1α) is a pivotal regulator of mitochondrial energy metabolism. Accumulating evidence reveals that PGC-1α is essential in cancer development. Objective: We summarize the latest research progress of PGC-1α in common digestive system malignant tumours. Some related modulators and pathways are analyzed as well. Methods: We conducted a literature review on the development of PGC-1α in common digestive system malignant tumours. Results: In colorectal cancer, PGC-1α appears to provide growth advantages by different pathways, although it has also been reported to have opposite effects. The previous studies of PGC-1α on liver cancer also demonstrated different effects by sundry pathways. Concerning gastric cancer, PGC-1α promotes cell proliferation, apoptosis in vitro and tumour growth in vivo. AMPK/SIRT1/PGC-1α is related to the inhibition of apoptosis in pancreatic cancer cells. Pancreatic cancer stem cells are strongly dependent on mitochondrial oxidative phosphorylation. PGC-1α is required to maintain the stemness property of pancreatic cancer stem cells. Conclusion: We explore diverse mechanisms that explain the dichotomous functions of PGC-1α on tumorigenesis, and discuss the latest research concerning digestive system malignant tumours. This review would provide better comprehension of the field and a basis for further studies associated with PGC-1α in digestive system cancers.

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