scholarly journals Effects of formaldehyde on vascular endothelial growth factor, matrix metallopeptidase 2 and osteonectin levels in periodontal membrane and alveolar bone in rats

2019 ◽  
Vol 78 (3) ◽  
pp. 545-553 ◽  
Author(s):  
N. Laçin ◽  
B. S. İzol ◽  
M. C. Tuncer ◽  
E. Gökalp Özkorkmaz ◽  
B. Deveci ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Alveolar Bone ◽  
Vascular Endothelial ◽  
Factor Matrix ◽  
Periodontal Membrane ◽  
Matrix Metallopeptidase ◽  
Endothelial Growth Factor

Expression of Vascular Endothelial Growth Factor and the Effects on Bone Remodeling during Experimental Tooth Movement

2003 ◽  
Vol 82 (3) ◽  
pp. 177-182 ◽  
Author(s):  
S. Kohno ◽  
M. Kaku ◽  
K. Tsutsui ◽  
M. Motokawa ◽  
J. Ohtani ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Bone Remodeling ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Vascular Endothelial ◽  
Mechanical Stimuli ◽  
Paracrine Factor ◽  
Endothelial Growth Factor ◽  
Experimental Tooth Movement

Vascular endothelial growth factor (VEGF) has an ability to induce functional osteoclasts as well as neovascularization. We recently reported that the number of osteoclasts was enhanced by the injection of recombinant human VEGF (rhVEGF) with the application of mechanical force for experimental tooth movement. In this study, the expression of VEGF was detected in osteoblasts on the tension side of the alveolar bone. Moreover, the rate of tooth movement was significantly increased in the rhVEGF injection groups compared with the controls. These results suggested that VEGF, highly expressed by mechanical stimuli, enhances the number of osteoclasts as a paracrine factor, and that the amount of tooth movement is accelerated by both endogenous VEGF and injected rhVEGF.

Meloxicam Temporally Inhibits the Expression of Vascular Endothelial Growth Factor Receptor (VEGFR)-1 and VEGFR-2 During Alveolar Bone Repair in Rats

2015 ◽  
Vol 86 (1) ◽  
pp. 162-172 ◽  
Author(s):  
Ricardo Vinicius Nunes Arantes ◽  
Tania Mary Cestari ◽  
Bruno Alvares Viscelli ◽  
Thiago José Dionísio ◽  
Gustavo Pompermaier Garlet ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Bone Repair ◽  
Alveolar Bone ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Expression and Correlation Analysis of Clinical Pathological Characteristics of Vascular Endothelial Growth Factor, Matrix Metalloproteinases and Microvessel Density in Lung Cancer with Bone Metastasis

2019 ◽  
Vol 9 (9) ◽  
pp. 1232-1237
Author(s):  
Xuefei Qi ◽  
Hong Liu ◽  
Ruiyun Liu ◽  
Lixin Sun ◽  
Xinjuan Yu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Bone Metastasis ◽  
Bone Metastases ◽  
Vascular Endothelial ◽  
Factor Matrix ◽  
Lung Cancer Patients ◽  
Tumor Group ◽  
Endothelial Growth Factor

Lung cancer is a common malignant tumor in clinic and easy to have bone metastases. Vascular endothelial growth factor (VEGF) is an angiogenic factor. Matrix metalloproteinases (MMPs) is associated with invasion and metastases. This study was to detect VEGF, microvessel density (MVD), MMP-2 and MMP-9 (MMP-2/9) levels in the serum and tissues of lung cancer patients with bone metastases to analyze the relaitonship between these changes and lung cancer with bone metastases. 60 patients with metastatic tumor of lung cancer were selected as experimental group, primary malignant tumor of bone and benign osteoma were regarded as control group, the contents of VEGF, MMP-2/9 in blood and tissues were analyzed by ELISA and IHC, respectively. VEGF, MVD, MMP-2/9 levels in serum and tissues of lung cancer bone metastasis group were significantly higher than that of primary bone tumor group and benign bone tumor group and their changes were significantly associated with pathological types of lung cancer, numbers and sizes of primary foci, numbers of bone metastases, other organ metastases and whether or not receiving radiotherapy and chemotherapy (P < 0.05). In conclusion, the level of VEGF, MVD, MMP-2/9 is significantly elevated in lung cancer patients with bone metastases, suggesting that these molecules might be involved in the pathogenesis of lung cancer with bone metastases.

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