scholarly journals The effect of nitro-oleic versus losartan in diabetic nephropathy: modulation of parathyroid hormone related protein

2015 ◽  
Author(s):  
Asmaa Mohammed ◽  
Nermeen Sadek ◽  
Mohamed Eshra ◽  
Effat Khowailed ◽  
Laila Rashed ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Parathyroid Hormone ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein

scholarly journals Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney: Evidence from Experimental and Human Diabetic Nephropathy

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Montserrat Romero ◽  
Arantxa Ortega ◽  
Nuria Olea ◽  
María Isabel Arenas ◽  
Adriana Izquierdo ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Parathyroid Hormone ◽  
Renal Injury ◽  
Renal Diseases ◽  
Protective Effects ◽  
Ang Ii ◽  
Related Protein ◽  
Renal Hypertrophy ◽  
Glomerular Diseases ◽  
Parathyroid Hormone Related Protein

Parathyroid hormone-related protein (PTHrP) and its receptor type 1 (PTH1R) are extensively expressed in the kidney, where they are able to modulate renal function. Renal PTHrP is known to be overexpressed in acute renal injury. Recently, we hypothesized that PTHrP involvement in the mechanisms of renal injury might not be limited to conditions with predominant damage of the renal tubulointerstitium and might be extended to glomerular diseases, such as diabetic nephropathy (DN). In experimental DN, the overexpression of both PTHrP and the PTH1R contributes to the development of renal hypertrophy as well as proteinuria. More recent data have shown, for the first time, that PTHrP is upregulated in the kidney from patients with DN. Collectively, animal and human studies have shown that PTHrP acts as an important mediator of diabetic renal cell hypertrophy by a mechanism which involves the modulation of cell cycle regulatory proteins and TGF-β1. Furthermore, angiotensin II (Ang II), a critical factor in the progression of renal injury, appears to be responsible for PTHrP upregulation in these conditions. These findings provide novel insights into the well-known protective effects of Ang II antagonists in renal diseases, paving the way for new therapeutic approaches.

scholarly journals The parathyroid hormone-related protein system and diabetic nephropathy outcome in streptozotocin-induced diabetes

2006 ◽  
Vol 69 (12) ◽  
pp. 2171-2178 ◽  
Author(s):  
A. Izquierdo ◽  
P. López-Luna ◽  
A. Ortega ◽  
M. Romero ◽  
M.A. Gutiérrez-Tarrés ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Parathyroid Hormone ◽  
Related Protein ◽  
Protein System ◽  
Parathyroid Hormone Related Protein ◽  
Streptozotocin Induced Diabetes

Parathyroid hormone-related protein is a hypertrophy factor for human mesangial cells: Implications for diabetic nephropathy

2012 ◽  
Vol 227 (5) ◽  
pp. 1980-1987 ◽  
Author(s):  
Arantxa Ortega ◽  
Montserrat Romero ◽  
Adriana Izquierdo ◽  
Nuria Troyano ◽  
Yolanda Arce ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Parathyroid Hormone ◽  
Mesangial Cells ◽  
Related Protein ◽  
Human Mesangial Cells ◽  
Parathyroid Hormone Related Protein

Parathyroid Hormone–Related Protein Inhibits Endothelin-1 Production

Hypertension ◽  
1996 ◽  
Vol 27 (3) ◽  
pp. 360-363 ◽  
Author(s):  
Bingbing Jiang ◽  
Shigeto Morimoto ◽  
Keisuke Fukuo ◽  
Atsushi Hirotani ◽  
Michio Tamatani ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Related Protein ◽  
Endothelin 1 ◽  
Parathyroid Hormone Related Protein

Parathyroid Hormone–Related Protein Upregulates Interleukin-1β–Induced Nitric Oxide Synthesis

Hypertension ◽  
1997 ◽  
Vol 30 (4) ◽  
pp. 922-927 ◽  
Author(s):  
Bingbing Jiang ◽  
Shigeto Morimoto ◽  
Jin Yang ◽  
Keisuke Fukuo ◽  
Atsushi Hirotani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Parathyroid Hormone ◽  
Interleukin 1Β ◽  
Nitric Oxide Synthesis ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein
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