scholarly journals Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane

2018 ◽  
Vol 77 (3) ◽  
pp. 471-477 ◽  
Author(s):  
B. Deveci ◽  
B. Ayna ◽  
İ. H. Tacir ◽  
E. Deveci ◽  
M. C. Tuncer ◽  
...  
2014 ◽  
Vol 6 (3) ◽  
pp. 191-200 ◽  
Author(s):  
Patricia Mesa-Gresa ◽  
Marta Ramos-Campos ◽  
Rosa Redolat

Life Sciences ◽  
1987 ◽  
Vol 40 (17) ◽  
pp. 1699-1708 ◽  
Author(s):  
L.Charles Murrin ◽  
James R. Ferrer ◽  
Zeng Wanyun ◽  
Nancy J. Haley

2004 ◽  
Vol 56 (3) ◽  
pp. 359-366 ◽  
Author(s):  
Göksel Sener ◽  
Caner Kapucu ◽  
Kübra Paskaloglu ◽  
Gül Ayanoglu-Dülger ◽  
Serap Arbak ◽  
...  

2009 ◽  
Vol 24 (11) ◽  
pp. 1709-1715 ◽  
Author(s):  
EL Mullings ◽  
LF Donaldson ◽  
JK Melichar ◽  
MR Munafò

2000 ◽  
Vol 867 (1-2) ◽  
pp. 157-164 ◽  
Author(s):  
Ming D Li ◽  
Justin K Kane ◽  
Steven L Parker ◽  
Kathy McAllen ◽  
Shannon G Matta ◽  
...  

2015 ◽  
Vol 22 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Omamuyovwi Meashack Ijomone ◽  
Olayemi Kafilat Olaibi ◽  
Christian Mba ◽  
Ifechukwude Joachim Biose ◽  
Samuel Anthony Tete ◽  
...  

1987 ◽  
Vol 10 (4) ◽  
pp. 376-383 ◽  
Author(s):  
Darrell G. Kirch ◽  
Greg A. Gerhardt ◽  
Richard C. Shelton ◽  
Robert Freedman ◽  
Richard J. Wyatt

2004 ◽  
Vol 11 (3) ◽  
pp. 563-568 ◽  
Author(s):  
Roma Kalra ◽  
Shashi P. Singh ◽  
Juan C. Pena-Philippides ◽  
Raymond J. Langley ◽  
Seddigheh Razani-Boroujerdi ◽  
...  

ABSTRACT To study the immunological effects of nicotine, there are several rodent models for chronic nicotine administration. These models include subcutaneously implanted miniosmotic pumps, nicotine-spiked drinking water, and self-administration via jugular cannulae. Administration of nicotine via these routes affects the immune system. Smokers frequently use nicotine patches to quit smoking, and the immunological effects of nicotine patches are largely unknown. To determine whether the nicotine patch affects the immune system, nicotine patches were affixed daily onto the backs of Lewis rats for 3 to 4 weeks. The patches efficiently raised the levels of nicotine and cotinine in serum and strongly inhibited the antibody-forming cell response of spleen cells to sheep red blood cells. The nicotine patch also suppressed the concanavalin A-induced T-cell proliferation and mobilization of intracellular Ca2+ by spleen cells, as well as the fever response of animals to subcutaneous administration of turpentine. Moreover, immunosuppression was associated with chronic activation of protein tyrosine kinase and phospholipase C-γ1 activities. Thus, in this animal model of nicotine administration, the nicotine patch efficiently raises the levels of nicotine and cotinine in serum and impairs both the immune and inflammatory responses.


Author(s):  
Ashley M. Francis ◽  
Andrea Parks ◽  
Joëlle Choueiry ◽  
Nicole El-Marj ◽  
Danielle Impey ◽  
...  

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