scholarly journals Incidental imaging findings of congenital rib abnormalities – a case series and review of developmental concepts

2018 ◽  
Vol 77 (2) ◽  
pp. 386-392 ◽  
Author(s):  
A.M. Aignătoaei ◽  
C.E. Moldoveanu ◽  
I.-D Căruntu ◽  
S.E. Giușcă ◽  
S. Partene Vicoleanu ◽  
...  
Keyword(s):  
Case Series ◽  
Imaging Findings

Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia patients requiring hospitalization (MAC-19 PRO): a case series

2020 ◽  
Vol 3 (3) ◽  
pp. 297-310 ◽  
Author(s):  
Rafael Ricafranca Castillo ◽  
Gino Rei A. Quizon ◽  
Mario Joselito M. Juco ◽  
Arthur Dessi E. Roman ◽  
Donnah G De Leon ◽  
...  
Keyword(s):  
Adjuvant Therapy ◽  
Hospital Stay ◽  
Clinical Improvement ◽  
Case Series ◽  
High Dose ◽  
Chest Imaging ◽  
Imaging Findings ◽  
Rt Pcr ◽  
Average Hospital ◽  
Sleeping Problems

 Treatment for coronavirus disease 2019 (COVID19) pneumonia remains empirical and the search for therapies that can improve outcomes continues. Melatonin has been shown to have anti-inflammatory, antioxidant, and immune-modulating effects that may address key pathophysiologic mechanisms in the development and progression of acute respiratory distress syndrome (ARDS), which has been implicated as the likely cause of death in COVID19. We aimed to describe the observable clinical outcomes and tolerability of high-dose melatonin (hdM) given as adjuvant therapy in patients admitted with COVID19 pneumonia. We conducted a retrospective descriptive case series of patients who: 1) were admitted to the Manila Doctors Hospital in Manila, Philippines, between March 5, 2020 and April 4, 2020; 2) presented with history of typical symptoms (fever, cough, sore throat, loss of smell and/or taste, myalgia, fatigue); 3) had admitting impression of atypical pneumonia; 4) had history and chest imaging findings highly suggestive of COVID19 pneumonia, and, 5) were given hdM as adjuvant therapy, in addition to standard and/or empirical therapy. One patient admitted to another hospital, who one of the authors helped co-manage, was included. He was the lone patient given hdM in that hospital during the treatment period. Main outcomes described were: time to clinical improvement, duration of hospital stay from hdM initiation, need for mechanical ventilation (MV) prior to cardiopulmonary resuscitation, and final outcome (death or recovery/discharge). Of 10 patients given hdM at doses of 36-72mg/day per os (p.o.) in 4 divided doses as adjuvant therapy, 7 were confirmed COVID19 positive (+) by reverse transcription polymerase chain reaction (RT-PCR) and 3 tested negative  (-), which was deemed to be false (-) considering the patients’ typical history, symptomatology, chest imaging findings and elevated bio-inflammatory parameters.  In all 10 patients given hdM, clinical stabilization and/or improvement was noted within 4-5 days after initiation of hdM. All hdM patients, including 3 with moderately severe ARDS and 1 with mild ARDS, survived; none required MV. The 7 COVID19(+) patients were discharged at an average of 8.6 days after initiation of hdM. The 3 highly probable COVID19 patients on hdM were discharged at an average of 7.3 days after hdM initiation. Average hospital stay of those not given hdM (non-hdM) COVID19(+) patients who were admitted during the same period and recovered was 13 days. To provide perspective, although the groups are not comparable, 12 of the 34 (35.3%) COVID19(+) non-hdM patients admitted during the same period died, 7/34 (20.6%) required MV; while 6 of 15 (40%) non-hdM (-) by RT-PCR but highly probable COVID19 pneumonia patients also died, 4/15  (26.7%) required MV. No significant side-effects were noted with hdM except for sleepiness, which was deemed favorable by all patients, most of whom had anxiety- and symptom-related sleeping problems previously. HdM may have a beneficial role in patients treated for COVID19 pneumonia, in terms of shorter time to clinical improvement, less need for MV, shorter hospital stay, and possibly lower mortality. HdM was well tolerated. This is the first report describing the benefits of hdM in patients being treated for COVID19 pneumonia.  Being a commonly available and inexpensive sleep-aid supplement worldwide, melatonin may play a role as adjuvant therapy in the global war against COVID19. 

scholarly journals Imaging in the Diagnosis of Cemento-Ossifying Fibroma: A Case Series

2012 ◽  
Vol 2 ◽  
pp. 52 ◽  
Author(s):  
R Mithra ◽  
Pavitra Baskaran ◽  
M Sathyakumar
Keyword(s):  
Treatment Planning ◽  
Fibrous Dysplasia ◽  
Case Series ◽  
Disease Process ◽  
Ossifying Fibroma ◽  
Imaging Findings ◽  
The Third ◽  
Osseous Lesion ◽  
Essential Tool ◽  
Slow Growing

Cemento-ossifying fibroma is a benign fibro-osseous lesion belonging to the same category as fibrous dysplasia and cementifying dysplasia. These are slow-growing lesions that are seen in the third and fourth decades of life. Both the ossifying fibroma and cemento-ossifying fibroma represent two extremes of the same disease process since histologically both contain bone and cementum. However, the term cemento-ossifying fibroma is justified on the basis of clinical and radiological correlation. Radiographs have become an essential tool in the diagnosis of lesions in the jaw, where the anatomy is complex. Nowadays, CT provides information for diagnosis as well as treatment planning. In this case series, we report three cases of cemento-ossifying fibroma that were histologically confirmed and discuss the imaging findings.

Management of degenerative lumbosacral disease in cats by dorsal laminectomy and lumbosacral stabilization

2013 ◽  
Vol 26 (01) ◽  
pp. 69-75 ◽  
Author(s):  
A. Danielski ◽  
J. Bertran ◽  
N. Fitzpatrick
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cauda Equina ◽  
Case Series ◽  
Normal Activity ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Dorsal Stabilization ◽  
Satisfactory Outcome ◽  
Dorsal Laminectomy ◽  
Suspected Diagnosis

SummaryIn this case series we describe the diagnosis and surgical treatment of five cats affected by clinical cauda equina syndrome as a result of degenerative lumbosacral stenosis. Radiographic and magnetic resonance imaging findings confirmed the suspected diagnosis of disc-associated lumbosacral disease. Cauda equina decompression was achieved by dorsal laminectomy followed by dorsal annulectomy and nuclear extirpation. Dorsal stabilization was achieved using miniature positive-profile pins inserted into the vertebral body of L7 and the wings of S1 with the free ends of the pins being embedded in a bolus of gentamicin-impregnated polymethylmethacrylate. Reassessment two years postoperatively using a previously validated feline specific owner questionnaire indicated satisfactory outcome with complete return to normal activity and resolution of signs of pain in all cases.

scholarly journals Chest imaging findings in COVID-19 patients: a case series from Nigeria

2020 ◽  
Vol 37 ◽  
Author(s):  
Olubukola Khadija Ajiboye ◽  
Oludolapo Sherifat Katibi ◽  
Ohiole Sherifat Ayeni ◽  
Chiedozie Osuoji ◽  
Olubusayo Abimbola Agbaje
Keyword(s):  
Case Series ◽  
Chest Imaging ◽  
Imaging Findings

Abstract TP399: Hemodynamic Imaging in Children with Transient Neurologic Symptoms

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Laura L Lehman ◽  
Amy R Danehy ◽  
Miya E Bernson-Leung ◽  
Cameron C Trenor ◽  
Christopher F Calahan ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Case Series ◽  
Imaging Findings ◽  
Diagnostic Challenge ◽  
Stroke Treatment ◽  
Neurologic Symptoms ◽  
Clinical Criteria ◽  
Hyperacute Stroke ◽  
Diffusion Weighted ◽  
Stroke Mimic

Children who present with transient neurologic symptoms raise concern for stroke as the underlying etiology. The rapid differentiation of stroke mimic from stroke in order to determine eligibility for hyperacute stroke treatment constitutes a unique and important diagnostic challenge in children. We used perfusion, diffusion, and magnetic resonance angiography (MRA) imaging to identify key imaging findings that together indicated a stroke mimic. We present a case series of 17 children who had transient neurologic symptoms and had MRA, perfusion, and diffusion weighted imaging in the acute period. The children ranged in age from 2 to 17 years of age. Among 17 children, 13 (76%) had headache at presentation. Thirteen (76%) children had focal MRA evidence of arterial pruning without occlusion, all had negative diffusion weighted imaging, and all showed evidence of hemispheric decreased perfusion by susceptibility-weighted imaging and/or arterial spin label perfusion imaging. Thirteen of 17 had left sided imaging findings. In all children who had repeat imaging (6/17;35%) these findings had reversed. No patient met clinical criteria for familial hemiplegic migraine. Only 6 (35%) had recurrence of transient neurologic symptoms since initial presentation; none had stroke. Use of combined MR imaging to include perfusion, diffusion and angiography can help to distinguish rapidly children who present with stroke mimics whose symptoms are likely to be transient and who do not require hyperacute stroke treatment.

Clinical and Imaging Findings in Multifocal Orbital Vascular Lesions: A Case Series

2009 ◽  
Vol 24 (6) ◽  
pp. 241-244 ◽  
Author(s):  
Efstathios T. Detorakis ◽  
Elena Drakonaki ◽  
George Kymionis ◽  
Ioannis G. Pallikaris ◽  
Miltiadis K. Tsilimbaris
Keyword(s):  
Case Series ◽  
Vascular Lesions ◽  
Imaging Findings
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