scholarly journals The beneficial roles of insulin and parathyroid hormones in the treatment of experimentally induced diabetic osteoporosis in female rats: bone mineral density, morphometric and histological studies

2016 ◽  
Vol 75 (3) ◽  
pp. 341-354 ◽  
Author(s):  
G. S. Abd El Aziz ◽  
W. S. Ramadan ◽  
M. O. El-Fark ◽  
H. A.M. Saleh
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Female Rats ◽  
Mineral Density ◽  
Histological Studies ◽  
Parathyroid Hormones ◽  
Diabetic Osteoporosis ◽  
Experimentally Induced

Impaired Estrogen Sensitivity in Bone by Inhibiting Both Estrogen Receptor a and b Pathways*

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Bone Loss ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Female Rats ◽  
Wild Type ◽  
Mineral Density ◽  
Transgenic Rats ◽  
Estrogen Sensitivity

Although it is well established that estrogen deficiencycauses osteoporosis among the postmenopausalwomen, the involvement of estrogen receptor (ER) in itspathogenesis still remains uncertain. In the presentstudy, we have generated rats harboring a dominantnegative ERa, which inhibits the actions of not only ERabut also recently identified ERb. Contrary to our expectation,the bone mineral density (BMD) of the resultingtransgenic female rats was maintained at the same levelwith that of the wild-type littermates when sham-operated.In addition, ovariectomy-induced bone loss wasobserved almost equally in both groups. Strikingly, however,the BMD of the transgenic female rats, after ovariectomized,remained decreased even if 17b-estradiol(E2) was administrated, whereas, in contrast, the decreaseof littermate BMD was completely prevented byE2. Moreover, bone histomorphometrical analysis ofovariectomized transgenic rats revealed that the higherrates of bone turnover still remained after treatmentwith E2. These results demonstrate that the preventionfrom the ovariectomy-induced bone loss by estrogen ismediated by ER pathways and that the maintenanceof BMD before ovariectomy might be compensatedby other mechanisms distinct from ERa and ERbpathways.

The effect of prolactin itself and in combination with estrogen on bone mineral density in female rats

2019 ◽  
Vol 35 (6) ◽  
pp. 539-543 ◽  
Author(s):  
Forough Saki ◽  
Faezeh Sadeghian ◽  
Seyed Reza Kasaee ◽  
Pedram Talezadeh ◽  
Gholam Hossein Ranjbar Omrani
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Female Rats ◽  
Mineral Density

scholarly journals Recovery Effects of a 180 mT Static Magnetic Field on Bone Mineral Density of Osteoporotic Lumbar Vertebrae in Ovariectomized Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Shenzhi Xu ◽  
Hideyuki Okano ◽  
Naohide Tomita ◽  
Yoshito Ikada
Keyword(s):  
Magnetic Field ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Static Magnetic Field ◽  
Lumbar Vertebrae ◽  
Exposed Group ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Moderate Intensity ◽  
Mineral Density

The effects of a moderate-intensity static magnetic field (SMF) on osteoporosis of the lumbar vertebrae were studied in ovariectomized rats. A small disc magnet (maximum magnetic flux density 180 mT) was implanted to the right side of spinous process of the third lumbar vertebra. Female rats in the growth stage (10 weeks old) were randomly divided into 4 groups: (i) ovariectomized and implanted with a disc magnet (SMF); (ii) ovariectomized and implanted with a nonmagnetized disc (sham); (iii) ovariectomized alone (OVX) and (vi) intact, nonoperated cage control (CTL). The blood serum 17--estradiol (E2) concentrations were measured by radioimmunoassay, and the bone mineral density (BMD) values of the femurs and the lumbar vertebrae were assessed by dual energy X-ray absorptiometry. The E2concentrations were statistically significantly lower for all three operated groups than those of the CTL group at the 6th week. Although there was no statistical significant difference in the E2concentrations between the SMF-exposed and sham-exposed groups, the BMD values of the lumbar vertebrae proximal to the SMF-exposed area statistically significantly increased in the SMF-exposed group than in the sham-exposed group. These results suggest that the SMF increased the BMD values of osteoporotic lumbar vertebrae in the ovariectomized rats.

scholarly journals Short- and long-term effects of calcium and exercise on bone mineral density in ovariectomized rats

2001 ◽  
Vol 86 (4) ◽  
pp. 521-527 ◽  
Author(s):  
Joseé Gala ◽  
Manuel Di´az-curiel ◽  
Concepcioó de la Piedra ◽  
Jesu´s Calero
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Exercise Programme ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Standard Diet ◽  
Mineral Density ◽  
Left Femur ◽  
Ovx Rats

At the level of prevention of bone mineral loss produced by ovariectomy, the aim of the present study was to determine the effect produced by supplementation of Ca in the diet and a moderate exercise programme (treadmill), simultaneously or separately, in ovariectomized rats, an experimental model of postmenopausal bone loss. Female Wistar rats (n110, 15 weeks old) were divided into five groups: (1) OVX, rats ovariectomized at 15 weeks of age, fed a standard diet; (2) SHAM, rats sham operated at 15 weeks of age, fed a standard diet; (3) OVX–EX, ovariectomized rats, fed a standard diet and performing the established exercise programme; (4) OVX–Ca, ovariectomized rats fed a diet supplemented with Ca; (5) OVX–EXCa, ovariectomized rats with the exercise programme and diet supplemented with Ca. The different treatments were initiated 1 week after ovariectomy and were continued for 13 weeks for subgroup 1 and 28 weeks for subgroup 2, to look at the interaction of age and time passed from ovariectomy on the treatments. Bone mineral density (BMD) was determined, at the end of the study, in the lumbar spine (L2, L3 and L4) and in the left femur using a densitometer. Bone turnover was also estimated at the end of the study, measuring the serum formation marker total alkaline phosphatase (AP) and the resorption marker serum tartrate-resistant acid phosphatase (TRAP). As expected, OVX rats showed a significant decrease (P<0·05) in BMD, more pronounced in subgroup 2, and a significant increase in AP and TRAP with regard to their respective SHAM group. The simultaneous treatment with Ca and exercise produced the best effects on lumbar and femoral BMD of ovariectomized rats, partially avoiding bone loss produced by ovariectomy, although it was not able to fully maintain BMD levels of intact animals. This combined treatment produced a significant increase in AP, both in subgroups 1 and 2, and a decrease in TRAP in subgroup 1, with regard to OVX group. The exercise treatment alone was able to produce an increase in BMD with regard to OVX group only in subgroup 1 of rats (younger animals and less time from ovariectomy), but not in subgroup 2. In agreement with this, there was an increase of AP in both subgroups, lower than that observed in animals submitted to exercise plus Ca supplement, and a decrease of TRAP in subgroup 1, without significant changes in this marker in the older rats. Ca treatment did not produce any significant effect on BMD in OVX rats in both subgroups of animals, showing a decrease of AP and TRAP levels in the younger animals with no significant variations in markers of bone remodelling in the older female rats compared with their respective OVX group.

scholarly journals Mechanism bySambucus nigraExtract Improves Bone Mineral Density in Experimental Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Laurentiu Badescu ◽  
Oana Badulescu ◽  
Magda Badescu ◽  
Manuela Ciocoiu
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Content ◽  
Diabetic Rats ◽  
Mineral Density ◽  
Sambucus Nigra ◽  
Polyphenolic Extract ◽  
Before And After ◽  
Total Antioxidant ◽  
Diabetic Osteoporosis

The effects of polyphenols extracted fromSambucus nigrafruit were studied in streptozotocin- (STZ-) induced hyperglycemic rats to evaluate its possible antioxidant, anti-inflammatory, antiglycosylation activity, and antiosteoporosis effects in diabetes. DEXA bone mineral density tests were performed in order to determine bone mineral density (BMD), bone mineral content (BMC), and fat (%Fat) in control and diabetic animals, before and after polyphenol delivery. As compared to the normoglycemic group, the rats treated with STZ (60 mg/kg body weight) revealed a significant malondialdehyde (MDA) increase, as an index of the lipid peroxidation level, by 69%, while the total antioxidant activity (TAS) dropped by 36%, with a consistently significant decrease () in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX). Also, the treatment of rats with STZ revealed a significant increase of IL-6, glycosylated haemoglobin (HbA1c), and osteopenia detected by DEXA bone mineral density tests. The recorded results highlight a significant improvement () in the antioxidative capacity of the serum in diabetic rats treated with natural polyphenols, bringing back to normal the concentration of reduced glutathione (GSH), as well as an important decrease in the serum concentration of MDA, with improved osteoporosis status. Knowing the effects of polyphenols could lead to the use of the polyphenolic extract ofSambucus nigraas a dietary supplement in diabetic osteoporosis.

Changes of bone mineral density and bone biomechanics in type 2 diabetic model of female rats

Bone ◽  
2008 ◽  
Vol 42 ◽  
pp. S59-S60
Author(s):  
Yaping Liu ◽  
Hong Ji ◽  
Haiqin Rong ◽  
Liping Zhang ◽  
Xinbo Zhao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Female Rats ◽  
Bone Biomechanics ◽  
Mineral Density ◽  
Diabetic Model ◽  
Type 2 Diabetic

Changes in Bone Mineral Density and Mechanical Properties Due to Alcohol and Ovariectomy in Trabecular Bone of Female Rats

2002 ◽  
Author(s):  
Harry A. Hogan ◽  
H. Wayne Sampson
Keyword(s):  
Mechanical Properties ◽  
Bone Mineral Density ◽  
Animal Model ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Female Rats ◽  
Mineral Density ◽  
Rat Animal Model

Alcohol consumption is a known risk factor exacerbating postmenopausal osteoporosis [1,2]. The current study was undertaken to investigate these effects using the rat animal model. Recent studies with rats have shown deleterious effects due to alcohol [3,4], but no significant effects when combined estrogen deficiency induced by ovariectomy (OVX) [5]. This last study did not report mechanical properties, however. The objective of the current study was to investigate the effects of alcohol and OVX on trabecular bone mechanical properties and bone mineral density (BMD) in adult female rats. An important issue in evaluating osteoporosis and related bone maladies clinically is the relation between bone mineral density (BMD) and fracture risk or incidence. Thus, an additional goal of the current study was to examine the relationships (correlations) between trabecular bone BMD and mechanical properties.

Combined Effects of Physical Activity, Dietary Isoflavones and 17β-Estradiol on Movement Drive, Body Weight and Bone Mineral Density in Ovariectomized Female Rats

Planta Medica ◽  
2006 ◽  
Vol 72 (06) ◽  
pp. 484-487 ◽  
Author(s):  
Torsten Hertrampf ◽  
Gisela Degen ◽  
Abdel Kaid ◽  
Ute Laudenbach-Leschowsky ◽  
Jan Seibel ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Body Weight ◽  
Bone Mineral ◽  
Female Rats ◽  
Combined Effects ◽  
Mineral Density ◽  
17Β Estradiol
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