scholarly journals Long term effects of maternal protein restriction on postnatal lung alveoli development of rat offspring

2015 ◽  
Vol 74 (4) ◽  
pp. 479-485 ◽  
Author(s):  
S. A. Farid ◽  
O. M. Mahmoud ◽  
N. A. Salem ◽  
G. Abdel-Alrahman ◽  
G. A. Hafez
Keyword(s):  
Protein Restriction ◽  
Long Term Effects ◽  
Rat Offspring ◽  
Maternal Protein Restriction

scholarly journals Higher Hepatic miR-29 Expression in Undernourished Male Rats During the Postnatal Period Targets the Long-Term Repression of IGF-1

Endocrinology ◽  
2016 ◽  
Vol 2016 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Gurjeev Sohi ◽  
Andrew Revesz ◽  
Julie Ramkumar ◽  
Daniel B. Hardy
Keyword(s):  
Gene Expression ◽  
Protein Restriction ◽  
Male Rats ◽  
Postnatal Life ◽  
Rat Offspring ◽  
The Metabolic Syndrome ◽  
Maternal Protein Restriction ◽  
Igf1 Expression ◽  
The Impact

Abstract A nutritional mismatch in postnatal life of low birth weight offspring increases the risk of developing the metabolic syndrome. Moreover, this is associated with decreased hepaticIgf1 expression, leading to impaired growth and metabolism. Previously, we have demonstrated that the timing of nutritional restoration in perinatal life can differentially program hepatic gene expression. Although microRNAs also play an important role in silencing gene expression, to date, the impact of a nutritional mismatch in neonatal life on their long-term expression has not been evaluated. Given the complementarity of miR-29 to the 3′ untranslated region of Igf1, we examined how protein restoration in maternal protein restriction rat offspring influences hepatic miR-29 and Igf1 expression in adulthood. Pregnant Wistar rats were designated into 1 of 4 dietary regimes: 20% protein (control), 8% protein during lactation only (LP-Lact), 8% protein during gestation only (LP1) or both (LP2). The steady-state expression of hepatic miR-29 mRNAsignificantly increased in LP2 offspring at postnatal day 21 and 130, and this was inversely related to hepatic Igf1 mRNA and body weight. Interestingly, this reciprocal association was stronger in LP-Lact offspring at postnatal day 21. Functional relevance of this in vivo relationship was evaluated by transfection of miR-29 mimics in neonatal Clone 9 rat hepatoma cells. Transfection with miR-29 suppressed Igf1 expression by 12 hours. Collectively, these findings implicate that nutritional restoration after weaning (post liver differentiation) in maternal protein restriction rat offspring fails to prevent long-term impaired growth, in part, due to miR-29 suppression of hepatic Igf1 expression. (Endocrinology 156: 3069–3076, 2015)

scholarly journals Long-term effects of pro-opiomelanocortin methylation induced in food-restricted dams on metabolic phenotypes in male rat offspring

2020 ◽  
Vol 63 (3) ◽  
pp. 239-250
Author(s):  
Sangmi Lee ◽  
Eun Jin Kwon ◽  
Young-Ah You ◽  
Ji Eun Du ◽  
Inho Jo ◽  
...  
Keyword(s):  
Male Rat ◽  
Long Term Effects ◽  
Metabolic Phenotypes ◽  
Rat Offspring

scholarly journals Maternal protein restriction induces gastrointestinal dysfunction and enteric nervous system remodeling in rat offspring

2018 ◽  
Vol 33 (1) ◽  
pp. 770-781 ◽  
Author(s):  
Philippe Aubert ◽  
Elena Oleynikova ◽  
Hina Rizvi ◽  
Marième Ndjim ◽  
Catherine Le Berre-Scoul ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Protein Restriction ◽  
Gastrointestinal Dysfunction ◽  
Rat Offspring ◽  
Maternal Protein Restriction

scholarly journals Long-term effects of maternal resveratrol intake during lactation on cholesterol metabolism in male rat offspring

2019 ◽  
Vol 71 (2) ◽  
pp. 226-234 ◽  
Author(s):  
Shojiro Yamasaki ◽  
Tomomi Tomihara ◽  
Goh Kimura ◽  
Yukako Ueno ◽  
Rahel Mesfin Ketema ◽  
...  
Keyword(s):  
Cholesterol Metabolism ◽  
Male Rat ◽  
Long Term Effects ◽  
Rat Offspring

scholarly journals Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e57608 ◽  
Author(s):  
Liesbeth Knaepen ◽  
Ine Rayen ◽  
Thierry D. Charlier ◽  
Marianne Fillet ◽  
Virginie Houbart ◽  
...  
Keyword(s):  
Maternal Stress ◽  
Sprague Dawley ◽  
Long Term Effects ◽  
Rat Offspring ◽  
Sprague Dawley Rat ◽  
Post Operative Pain

Protective effect of E uterpe oleracea  Mart (açaí) extract on programmed changes in the adult rat offspring caused by maternal protein restriction during pregnancy

2014 ◽  
Vol 66 (9) ◽  
pp. 1328-1338 ◽  
Author(s):  
Graziele Freitas de Bem ◽  
Cristiane Aguiar da Costa ◽  
Paola Raquel Braz de Oliveira ◽  
Viviane Silva Cristino Cordeiro ◽  
Izabelle Barcellos Santos ◽  
...  
Keyword(s):  
Protective Effect ◽  
Protein Restriction ◽  
Adult Rat ◽  
Rat Offspring ◽  
Maternal Protein Restriction
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