scholarly journals Effect of human papillomavirus on cell cycle-related proteins p16INK4A, p21waf1/cip1, p53 and cyclin D1 in sinonasal inverted papilloma and laryngeal carcinoma. An in situ hybridization study

2011 ◽  
Vol 49 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Olga Stasikowska-Kanicka ◽  
Małgorzata Wągrowska-Danilewicz ◽  
Marian Danilewicz
Keyword(s):  
Cell Cycle ◽  
Human Papillomavirus ◽  
Cyclin D1 ◽  
Laryngeal Carcinoma ◽  
Inverted Papilloma ◽  
Hybridization Study ◽  
Sinonasal Inverted Papilloma ◽  
Related Proteins

scholarly journals Effect of Human Papillomavirus on Cell Cycle–Related Proteins p16, Ki-67, Cyclin D1, p53, and ProEx C in Precursor Lesions of Cervical Carcinoma

2009 ◽  
Vol 132 (3) ◽  
pp. 378-390 ◽  
Author(s):  
Pablo Conesa-Zamora ◽  
Asunción Doménech-Peris ◽  
Francisco J. Orantes-Casado ◽  
Sebastián Ortiz-Reina ◽  
Laura Sahuquillo-Frías ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Human Papillomavirus ◽  
Cyclin D1 ◽  
Cervical Carcinoma ◽  
Precursor Lesions ◽  
Ki 67 ◽  
Related Proteins

Pattern of Expression of Cell Cycle–related Proteins in Malignant Transformation of Sinonasal Inverted Papilloma

2011 ◽  
Vol 25 (2) ◽  
pp. 75-81 ◽  
Author(s):  
Sun-Gui Kim ◽  
O-Young Lee ◽  
Jin-Woong Choi ◽  
Yong-Ho Park ◽  
Yong-Min Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Malignant Transformation ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma ◽  
Related Proteins

Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma

2019 ◽  
Vol 161 (6) ◽  
pp. 1036-1042 ◽  
Author(s):  
Ivy W. Maina ◽  
Charles C. L. Tong ◽  
Esther Baranov ◽  
Neil N. Patel ◽  
Vasiliki Triantafillou ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Recurrence Rate ◽  
Carcinoma In Situ ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma ◽  
Definitive Surgery ◽  
Severe Degree ◽  
Multiple Recurrences

Objective Sinonasal inverted papilloma (IP) is a typically benign sinonasal tumor with a tendency to recur and the potential for malignant transformation. Varying degrees of dysplasia may be present, of which carcinoma in situ (CIS) is most advanced. We hereby describe the biological and clinical behavior of IP with CIS (IPwCIS). Study Design Retrospective cohort. Setting Tertiary academic referral center. Subjects and Methods Patients who underwent surgical resection for IP between 2002 and 2017. Pertinent clinical data were obtained, and all IPwCIS cases were histologically confirmed. Results In total, 37 of 215 cases (17.2%) were identified with IPwCIS. Mean age was 57 years and 86.5% of patients were male. Median follow-up was 82 months, and the recurrence rate was 27%. The maxillary sinus was the most common primary site (37.8%) and 14 tumors (37.8%) demonstrated multifocal attachment, which was associated with recurrence (odds ratio [OR], 9.7; 95% confidence interval [CI], 1.4-112.8; P = .028). IPwCIS was also associated with multiple recurrences (OR, 2.71; 95% CI, 1.246-5.814; P = .021). Most patients were treated with surgery alone (89.1%) and 4 patients received adjuvant radiotherapy (8.1%). Only 1 patient (2.7%) demonstrated malignant transformation after definitive surgery. Conclusions IPwCIS represents the most severe degree of dysplasia prior to malignant transformation and is associated with higher recurrence rate and multifocal involvement but low rate of conversion to invasive carcinoma. The need for adjuvant therapy remains controversial, and further research into the etiology of the disease is warranted.

scholarly journals Role of the Akt/mTOR signaling pathway in human papillomavirus-associated nasal and sinonasal inverted papilloma

2017 ◽  
Vol 49 (12) ◽  
pp. 1067-1074 ◽  
Author(s):  
Yongliang Liu ◽  
Lihua Duan ◽  
Jie Tian ◽  
Daoliang Song ◽  
Min Zhang ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Inverted Papilloma ◽  
Mtor Signaling Pathway ◽  
Sinonasal Inverted Papilloma

scholarly journals Immunohistochemical Expression of EGFR, NF-kB and Cyclin D1 in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma

2020 ◽  
Vol 12 (3) ◽  
pp. 239-44
Author(s):  
Pudji Rahaju ◽  
Rio Auricknaga Kintono ◽  
Ahmad Dian Wahyudiono ◽  
Arif Satria ◽  
Ferry Sandra
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
Inverted Papilloma ◽  
Cross Sectional ◽  
Sinonasal Inverted Papilloma

BACKGROUND: Sinonasal inverted papilloma (SIP), a benign epithelial growth in the sinonasal region with epidermoid epithelial transformation, has been known for its invasiveness, recurrency, and its link with malignancy. Meanwhile sinonasal squamous cell carcinoma (SSCC) is an epithelial malignancy on squamous cells from the sinonasal region. Epidermal growth factor receptor (EGFR), Nuclear Factor kB (NF-kB), and Cyclin D1 are factors those might play important role in proliferation of SIP and SSCC. This research was conducted to investigate the expressions of EGFR, NF-kB and Cyclin D1 in SIP and SSCC.METHODS: A cross-sectional study by examining the EGFR, NF-kB, and Cyclin D1 immunohistochemical expressions of SIP and SSCC was conducted. Subjects whose blocks were used in this research, were diagnosed as SIP and SSCC at the Otorhinolaryngology-Head and Neck Surgery Clinic, Dr. Saiful Anwar General Hospital. Samples were selected, processed for inmmunohistochemistry, evaluated and statistical analyzed.RESULTS: Twenty-four SIP and 9 SSCC subjects with their paraffin blocks were selected. Clear immunohistochemical expressions of EGFR, NF-kB, and Cyclin D1 were observed for both SIP and SSCC. Significantly higher immunostaining levels of EGFR (45.6%, p=0.001) and NF-kB (42.2%, p=0.013) were observed in SSCC. Immunostaining levels of EGFR vs. NF-kB were moderately correlated (p=0.03, r=0.437), while the immunostaining levels of NF-kB vs. Cyclin D1 were strongly correlated (p=0.002, r=0.602).CONCLUSION: Expression of EGFR and NF-kB in SSCC were higher than the EGFR and NF-kB expression in SIP, suggesting that EGFR and NF-kB play important role in sinonasal malignancy.KEYWORDS: sinonasal, inverted papilloma, SCC, EGFR, NF-kB, Cyclin D1

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