scholarly journals Thyroid scintigraphy in three-year-old children with congenital hypothyroidism in correlation with neonatal TSH

2019 ◽  
Vol 70 (1) ◽  
pp. 43-48
Author(s):  
Majid Aminzadeh
Keyword(s):  
Congenital Hypothyroidism ◽  
Thyroid Scintigraphy

scholarly journals Thyroglobulin Gene Mutation with Cold Nodule on Thyroid Scintigraphy

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Toshio Kahara ◽  
Noboru Igarashi ◽  
Akira Hishinuma ◽  
Yuko Nakanishi ◽  
Akio Uchiyama ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Gene Mutation ◽  
Congenital Hypothyroidism ◽  
Elevated Serum ◽  
Gene Mutations ◽  
Thyroid Scintigraphy ◽  
Serum Thyroglobulin ◽  
Hyperplastic Nodule ◽  
Thyroglobulin Gene ◽  
Cold Nodule

Thyroglobulin gene mutation is a rare cause of congenital hypothyroidism, but thyroglobulin gene mutations are thought to be associated with thyroid cancer development. A 21-year-old Japanese man treated with levothyroxine for congenital hypothyroidism had an enlarged thyroid gland with undetectable serum thyroglobulin despite elevated serum TSH level. The patient was diagnosed with thyroglobulin gene mutation, with compound heterozygosity for Gly304Cys missense mutation and Arg432X nonsense mutation. Ultrasonography showed a hypovascular large tumor in the left lobe that appeared as a cold nodule on thyroid scintigraphy. He underwent total thyroidectomy, but pathological study did not reveal findings of thyroid carcinoma, but rather a hyperplastic nodule with hemorrhage. Strong cytoplasmic thyroglobulin immunostaining was observed, but sodium iodide symporter immunostaining was hardly detected in the hyperplastic nodule. The clinical characteristics of patients with thyroglobulin gene mutations are diverse, and some patients are diagnosed by chance on examination of goiter in adults. The presence of thyroid tumors that appear as cold nodules on thyroid scintigraphy should consider the potential for thyroid carcinoma, if the patient has relatively low serum thyroglobulin concentration in relation to the degree of TSH without thyroglobulin autoantibody.

Thyroid scintigraphy and perchlorate discharge test in the diagnosis of congenital hypothyroidism

1995 ◽  
Vol 22 (9) ◽  
pp. 1005-1008 ◽  
Author(s):  
Mahmoud EI-Desouki ◽  
Nasir AI-Jurayyan ◽  
Abdulrahman AI-Nuaim ◽  
Abdullah AI-Herbish ◽  
Abdullah Abo-Bakr ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Thyroid Scintigraphy ◽  
Perchlorate Discharge Test ◽  
Discharge Test

[Tc]-99m Thyroid Scintigraphy in Congenital Hypothyroidism Screening Program

2006 ◽  
Vol 52 (6) ◽  
pp. 411-415 ◽  
Author(s):  
R. Iranpour ◽  
M. Hashemipour ◽  
M. Amini ◽  
S. M. Talaei ◽  
R. Kelishadi ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Screening Program ◽  
Thyroid Scintigraphy

scholarly journals Thyroid scintigraphy differentiates subtypes of congenital hypothyroidism

2019 ◽  
Vol 106 (1) ◽  
pp. 77-79 ◽  
Author(s):  
Chris Worth ◽  
Beverly Hird ◽  
Lesley Tetlow ◽  
Neville Wright ◽  
Leena Patel ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Thyroid Stimulating Hormone ◽  
Dried Blood Spot ◽  
Thyroid Scintigraphy ◽  
Tertiary Centre ◽  
Blood Spot ◽  
Expected Proportion

IntroductionUK screening for congenital hypothyroidism (CH) is based on dried blood spot Thyroid Stimulating Hormone (TSH). Scintigraphy may identify CH subtypes classified as dysplasia, gland in situ (GIS) and ectopia, but is not performed in all centres. We retrospectively investigated the role of scintigraphy to identify CH subtypes in a single tertiary centre cohort.MethodsBabies who screened positive for CH between 2007 and 2017 were studied (n=418 of 534 783). Scintigraphy outcomes were correlated with TSH and levothyroxine dose. GIS patients were analysed for 3-year outcomes.Results303 patients started levothyroxine. Scintigraphy demonstrated three subtypes: GIS (n=139, 46%) ectopia (n=84, 28%) and dysplasia (n=80, 26%). Three-year follow up demonstrated permanence in 54% of 37 GIS cases.DiscussionThyroid scintigraphy differentiates subtypes of CH and suggests a higher than expected proportion of patients with GIS and ectopia. CH is permanent in half of those with GIS.

The Key Role of Newborn Thyroid Scintigraphy With Isotopic Iodide (123I) in Defining and Managing Congenital Hypothyroidism

PEDIATRICS ◽  
2004 ◽  
Vol 114 (6) ◽  
pp. e683-e688 ◽  
Author(s):  
E. J. Schoen ◽  
W. Clapp ◽  
T. T. To ◽  
B. H. Fireman
Keyword(s):  
Congenital Hypothyroidism ◽  
Thyroid Scintigraphy

Congenital Hypothyroidism

2018 ◽  
Author(s):  
Elfrida Kote Ollomani ◽  
Ada Pema
Keyword(s):  
Congenital Hypothyroidism
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