scholarly journals Antiplatelet effects of prostacyclin analogues: which one to choose in case of thrombosis or bleeding?

2020 ◽  
Author(s):  
Sylwester P. Rogula ◽  
Hubert M. Mutwil ◽  
Aleksandra Gąsecka ◽  
Marcin Kurzyna ◽  
Krzysztof J. Filipiak
Keyword(s):  
Prostacyclin Analogues

Synthesis of stable prostacyclin analogues

1982 ◽  
Vol 23 (36) ◽  
pp. 3647-3650 ◽  
Author(s):  
W Bartmann ◽  
G Beck ◽  
J Knolle ◽  
R.H Rupp
Keyword(s):  
Prostacyclin Analogues

SYNTHESIS AND PHARMACOLOGY OF NEW PROSTACYCLIN ANALOGUES

Prostanoids ◽  
1980 ◽  
pp. 1-8
Author(s):  
V. Simonidesz ◽  
I. Stadler ◽  
Á. Behr-Papp ◽  
J. Ivanics ◽  
J. Dér ◽  
...  
Keyword(s):  
Prostacyclin Analogues

scholarly journals Balloon atrial septostomy and transition of subcutaneous to intravenous prostacyclin infusion for rescuing advanced right heart failure in idiopathic pulmonary arterial hypertension: a case report

2020 ◽  
Vol 4 (3) ◽  
pp. 1-5
Author(s):  
Kae-Woei Liang ◽  
Kuo-Yang Wang
Keyword(s):  
Heart Failure ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Right Heart Failure ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Right Heart ◽  
Balloon Atrial Septostomy ◽  
Atrial Septostomy ◽  
Pulmonary Arterial ◽  
Prostacyclin Analogues

Abstract Background Intravenous (IV) prostacyclin analogues infusion and balloon atrial septostomy (BAS) are two important treatment options for managing advanced right heart failure in patients with idiopathic pulmonary arterial hypertension (IPAH). References and protocols are rare for dose titrations and transitions between subcutaneous and IV prostacyclin in functional Class IV IPAH patients. Balloon atrial septostomy is rarely done in very few expert centres. Case summary A young female with IPAH who had received maximal medication including subcutaneous prostacyclin analogues injection was admitted due to advanced right heart failure. She received ascites drainage twice. Later, we directly switched the administration route of prostacyclin from subcutaneous to IV at a ratio of 1:1 instantly. Such rapid conversion led her into a state of profound hypotension and drowsy consciousness, which was resolved after escalating IV inotropics and reducing prostacyclin dosage. Five days later, she received BAS under the guidance of intracardiac echocardiography. Her urine output increased and dyspnoea improved gradually. Six months later, clinical worsening happened again with increase of ascites and dyspnoea. She underwent 2nd and 3rd session of graded BAS with relief of symptoms again. She received permanent transition to IV prostacyclin analogues infusions via a peripherally inserted central catheter after three sessions of BAS. Discussion Balloon atrial septostomy is effective in stabilizing the critical right heart failure in IPAH patients but should be intended as a bridge to lung transplant procedure. Transition from subcutaneous to IV prostacyclin is helpful but needs to be titrated in proper aliquots and time intervals to avoid abrupt haemodynamic changes.

PROSTACYCLIN ANALOGUES AS ANTIATHEROSCLEROTIC DRUGS

The Lancet ◽  
1983 ◽  
Vol 322 (8348) ◽  
pp. 521 ◽  
Author(s):  
AlexanderN. Orekhov ◽  
VladimirV. Tertov ◽  
VladimirN. Smirnov
Keyword(s):  
Prostacyclin Analogues

scholarly journals Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists

2016 ◽  
Vol 8 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Isamu Sugimoto ◽  
Tohru Kambe ◽  
Tomotaka Okino ◽  
Tetsuo Obitsu ◽  
Nobukazu Ohta ◽  
...  
Keyword(s):  
Prostacyclin Analogues

Synthesis of prostacyclin analogues via knoevenagel condensation

1983 ◽  
Vol 24 (3) ◽  
pp. 315-318 ◽  
Author(s):  
J. Ivanics ◽  
V. Simonidesz ◽  
G. Galambos ◽  
P. Körmöczy ◽  
G. Kovács
Keyword(s):  
Knoevenagel Condensation ◽  
Prostacyclin Analogues

ChemInform Abstract: The Synthesis of Heteroaromatic Prostacyclin Analogues via Keto Alkyne Cyclization.

ChemInform ◽  
1987 ◽  
Vol 18 (48) ◽  
Author(s):  
S. COOK ◽  
D. HENDERSON ◽  
K. A. RICHARDSON ◽  
R. J. K. TAYLOR ◽  
J. SAUNDERS ◽  
...  
Keyword(s):  
Prostacyclin Analogues

ChemInform Abstract: Potent Prostacyclin Analogues Based on the Bicyclo(4.2.0)octane Ring System.

ChemInform ◽  
1988 ◽  
Vol 19 (1) ◽  
Author(s):  
A. F. KLUGE ◽  
D. J. KERTESZ ◽  
C. O-YANG ◽  
H. Y. WU
Keyword(s):  
Ring System ◽  
Prostacyclin Analogues
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