scholarly journals High mobility group box-1 in hypothalamic paraventricular nuclei attenuates sympathetic tone in rats at post-myocardial infarction

2019 ◽  
Vol 26 (5) ◽  
pp. 555-563 ◽  
Author(s):  
Pang Li ◽  
Yin Jie ◽  
Shi YuGen ◽  
Wang Yu ◽  
Suhua Yan
Keyword(s):  
Myocardial Infarction ◽  
High Mobility ◽  
Sympathetic Tone ◽  
Post Myocardial Infarction ◽  
High Mobility Group ◽  
Paraventricular Nuclei ◽  
Hypothalamic Paraventricular Nuclei

High Mobility Group Box-1 (HMGB1): A Potential Target in Therapeutics

2019 ◽  
Vol 20 (14) ◽  
pp. 1474-1485 ◽  
Author(s):  
Eyaldeva C. Vijayakumar ◽  
Lokesh Kumar Bhatt ◽  
Kedar S. Prabhavalkar
Keyword(s):  
Myocardial Infarction ◽  
Vagus Nerve Stimulation ◽  
Nuclear Protein ◽  
Therapeutic Potential ◽  
High Mobility ◽  
Dna Binding Protein ◽  
High Mobility Group ◽  
Eukaryotic Cells ◽  
Hmgb1 Protein

High mobility group box-1 (HMGB1) mainly belongs to the non-histone DNA-binding protein. It has been studied as a nuclear protein that is present in eukaryotic cells. From the HMG family, HMGB1 protein has been focused particularly for its pivotal role in several pathologies. HMGB-1 is considered as an essential facilitator in diseases such as sepsis, collagen disease, atherosclerosis, cancers, arthritis, acute lung injury, epilepsy, myocardial infarction, and local and systemic inflammation. Modulation of HMGB1 levels in the human body provides a way in the management of these diseases. Various strategies, such as HMGB1-receptor antagonists, inhibitors of its signalling pathway, antibodies, RNA inhibitors, vagus nerve stimulation etc. have been used to inhibit expression, release or activity of HMGB1. This review encompasses the role of HMGB1 in various pathologies and discusses its therapeutic potential in these pathologies.

scholarly journals Porphyromonas Gingivalis Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice

2017 ◽  
Vol 58 (5) ◽  
pp. 762-768 ◽  
Author(s):  
Rungtiwa Srisuwantha ◽  
Yuka Shiheido ◽  
Norio Aoyama ◽  
Hiroki Sato ◽  
Keitetsu Kure ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Porphyromonas Gingivalis ◽  
High Mobility ◽  
High Mobility Group

Abstract 3659: High-Mobility Group Box 1 Restores Cardiac Dysfunction after Myocardial Infarction in Transgenic Mice

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Tatsuro Kitahara ◽  
Yasuchika Takeishi ◽  
Tetsuro Shishido ◽  
Satoshi Suzuki ◽  
Shigehiko Kato ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Cardiac Dysfunction ◽  
Nuclear Dna ◽  
Inflammatory Responses ◽  
High Mobility ◽  
Left Ventricular ◽  
High Mobility Group ◽  
Coronary Artery Ligation ◽  
Artery Ligation

High-mobility group box 1 (HMGB1) is a nuclear DNA-binding protein and is released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. To test the hypothesis that HMGB1 enhances angiogenesis and restores cardiac dysfunction after myocardial infarction, we generated transgenic mouse with cardiac specific overexpression of HMGB1 (HMGB1-Tg) using α-myosin heavy chain (MHC) promoter. The left anterior descending coronary artery was ligated in HMGB1-Tg and wild-type littermate (Wt) mice. After coronary artery ligation, HMGB1 was released into circulation from the necrotic cardiomyocytes of HMGB1 overexpressing hearts. The size of myocardial infarction was smaller in HMGB1-Tg than in Wt mice (figure ). Echocardiography and cardiac catheterization demonstrated that cardiac remodeling and dysfunction after myocardial infarction were prevented in HMGB1-Tg mice compared to Wt mice. Furthermore, survival rate after myocardial infarction in HMGB1-Tg mice was higher than that in Wt mice (figure ). Immunohistochemical staining revealed that capillary and arteriole formations after myocardial infarction were enhanced in HMGB1-Tg mice. We demonstrated the first in vivo evidence that HMGB1 enhances angiogenesis, restores cardiac dysfunction, and improves survival after myocardial infarction. These results may provide a novel therapeutic approach for left ventricular dysfunction after myocardial infarction.

scholarly journals Plasma High-Mobility Group Box 1 Levels Predict Mortality After ST-Segment Elevation Myocardial Infarction

2011 ◽  
Vol 4 (3) ◽  
pp. 281-286 ◽  
Author(s):  
Morten V. Sørensen ◽  
Sune Pedersen ◽  
Rasmus Møgelvang ◽  
Jan Skov-Jensen ◽  
Allan Flyvbjerg
Keyword(s):  
Myocardial Infarction ◽  
High Mobility ◽  
High Mobility Group ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment

Effects of Exercise Training on High-Mobility Group Box-1 Levels After Acute Myocardial Infarction

2011 ◽  
Vol 17 (2) ◽  
pp. 108-114 ◽  
Author(s):  
Francesco Giallauria ◽  
Plinio Cirillo ◽  
Mariantonietta D’agostino ◽  
Gianluca Petrillo ◽  
Alessandra Vitelli ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Exercise Training ◽  
High Mobility ◽  
High Mobility Group

scholarly journals High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice

2008 ◽  
Vol 80 (1) ◽  
pp. 40-46 ◽  
Author(s):  
T. Kitahara ◽  
Y. Takeishi ◽  
M. Harada ◽  
T. Niizeki ◽  
S. Suzuki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Transgenic Mice ◽  
Cardiac Function ◽  
High Mobility ◽  
High Mobility Group
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