scholarly journals Predictive and protective role of high-density lipoprotein cholesterol in acute myocardial infarction

Author(s):  
Jin Sup Park ◽  
Kwang Soo Cha ◽  
Hye Won Lee ◽  
Jun-Hyok Oh ◽  
Jung Hyun Choi ◽  
...  
Medicine ◽  
2016 ◽  
Vol 95 (18) ◽  
pp. e3319 ◽  
Author(s):  
Cheol Hyun Lee ◽  
Jong Shin Woo ◽  
Chang Bum Park ◽  
Jin Man Cho ◽  
Young Keun Ahn ◽  
...  

2021 ◽  
Vol 36 (2) ◽  
pp. 82-88
Author(s):  
Md Sahadat Hossain ◽  
Prabir Kumar Das ◽  
Syed Ali Ahsan ◽  
Biplob Bhattacharjee ◽  
Anisul Awal ◽  
...  

Background: In acute myocardial infarction (AMI) the extent of the coronary artery lesion is evaluated by coronary angiogram (CAG). Recent evidences suggest that, ratio of triglyceride and high-density lipoprotein cholesterol (TG/HDL-C) could be a non-invasive marker for the prediction of the extent of coronary artery lesion. The aim of this study was to evaluate the association between TG/HDL-C ratio and the extent of coronary artery lesion assessed by coronary CAG among AMI patients. Objective: The aim of this study was to assess relationship between TG to HDL-C ratio and extent of coronary artery lesion in AMI patients. Materials & Method: This cross-sectional study was carried out in the Department of Cardiology, Chittagong Medical College Hospital in 224 admitted AMI patients. Blood samples were taken within 24 hours of admission following AMI for fasting lipid profile assessment, (total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol (LDL-C) and TG). Each patient was underwent CAG within 2 to 6 weeks of the events and angiographic findings were classified according to presence of significant stenosis, number of vessel involved and Gensini score. Results: The subjects consisted of 197 males and 27 females with a mean age of 51.24 (±11.22) years. Mean value of TC was 185.74 (±41.96) mg/ dL, TG was 222.17 (±99.05) mg/dL, HDL-C was 38.92 (±5.46) mg/dL, LDL-C was 127.99 (±36.94) mg/dL, TG/HDL-C was 5.91 (±2.99), median Gensini score was 28 (Range:1-146). Analysis of receiver operating characteristic curves showed that only TG/HDLC and TG were useful for detecting high Gensini score (score >42), with the former more area under the curve (AUC: 0.611; 95% CI: 0.531-0.691; p=0.008). The TG/HDL-C was an independent predictive factor (Odds ratio: 2.706; 95% CI: 1.397-5.242; p = 0.003) for the presence of significant coronary artery lesion on CAG. Linear regression analysis revealed that, age and TG/HDL-C ratio significantly predicted Gensini score. Conclusion: TG and HDL-C ratio was independently associated with extent of coronary artery lesion. Bangladesh Heart Journal 2021; 36(2): 82-88


1987 ◽  
Vol 33 (1) ◽  
pp. 21-23 ◽  
Author(s):  
M Speich ◽  
P Chappuis ◽  
N Robinet ◽  
S Gelot ◽  
P Arnaud ◽  
...  

Abstract We determined concentrations of selenium, zinc, magnesium, calcium, potassium, total and high-density lipoprotein cholesterol, and total creatine kinase (EC 2.7.3.2) in plasma (P) and (or) erythrocytes (E) of 32 men at the time of hospital admission for acute myocardial infarction and then on subsequent days 2, 3, 6, 10, and 12. During these 12 days, only P-selenium and high-density lipoprotein cholesterol concentrations remained unchanged. For the other variables, individual comparison of means indicated the dates of significant changes in concentration (p less than 0.05).


2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Jaka K. Alia ◽  
Edmond L. Jim ◽  
Agnes L. Panda

Abstract: Acute myocardial infarction (AMI) is caused by sudden disturbance of oxygen need and supply to the heart, affected by atheroma rupture that results in thrombocyte aggregation, thrombus formation, and coronary spasm that clogs the coronary artery. Patients that make it after a myocardial infarction have an increased risk of recurring infarctions with a yearly death number of 5%, six times higher than people of the same age without coronary artery disease. This study was aimed to determine the correlation between triglyceride/high density lipoprotein-cholesterol and AMI incidence at Prof. Dr. R. D. Kandou Hospital, Manado. This was an analytical and observational study with a cross sectional and retrospective approaches. This study showed that mean TG/HDL-C ratio was higher in subjects with AMI than in subjects without AMI. The Pearson correlation test showed a p-value of 0.553 for the correlation between mean TG/HDL-C ratio and AMI incidence. In conclusion, there was no reltionship between mean TG/HDL-C ratio and acute myocardial infarction incidence.Keywords: TG/HDL-C ratio, acute myocardial infarction, dyslipidemia Abstrak: Infark miokard akut (IMA) disebabkan oleh gangguan kebutuhan dan pasokan oksigen ke jantung secara mendadak disebabkan oleh ruptur ateroma yang berlanjut dengan agregasi trombosit, terbentuknya trombus, dan spasme koroner sehingga menyumbat arteri koroner. Pasien yang selamat dari infark miokard mengalami peningkatan risiko infark berulang dan memiliki tingkat kematian tahunan 5%, enam kali lipat pada orang dengan usia yang sama dan tidak menderita penyakit jantung koroner. Penelitian ini bertujuan untuk mengetahui hubungan rasio trigliserida/kolesterol-HDL dengan kejadian infark miokard akut di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Hasil penelitian mendapatkan bahwa rerata kadar rasio TG/HDL-C lebih tinggi pada subjek yang menderita IMA dibandingkan subjek non-IMA. Hasil uji korelasi Pearson terhadap hubungan antara rasio TG/HDL-C dengan kejadian IMA mendapatkan nilai p=0,553. Simpulan penelitian ini ialah tidak terdapat hubungan antara rasio TG/HDL-C dengan kejadian infark miokard akut.Kata kunci: rasio TG/HDL-C, infark miokard akut, dislipidemia


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