scholarly journals Emphysema as a possible complication of infant respiratory distress syndrome leading to lung transplantation

2021 ◽  
Author(s):  
Fryderyk Zawadzki ◽  
Marta Wajda-Pokrontka ◽  
Tomasz Stącel ◽  
Maciej Urlik ◽  
Mirosław Nęcki ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Lung Transplantation ◽  
Distress Syndrome ◽  
Infant Respiratory Distress Syndrome

Lung transplantation for acute respiratory distress syndrome – a retrospective European Cohort Study

2021 ◽  
pp. 2102078
Author(s):  
Jens Gottlieb ◽  
Philipp M. Lepper ◽  
Cristina Berastegui ◽  
Beatriz Montull ◽  
Alexandra Wald ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Acute Respiratory Distress Syndrome ◽  
Cohort Study ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Lung Transplantation ◽  
Distress Syndrome ◽  
Selection Process ◽  
Multivariable Analysis ◽  
Multicenter Cohort Study

BackgroundThe published experience of lung transplantation (LTX) in acute respiratory distress syndrome (ARDS) is limited. The aim of this study was to investigate the contemporary results of LTX attempts in ARDS in major European centers.MethodsWe conducted a retrospective multicenter cohort study of all patients listed for LTX between 2011 and 2019. We surveyed 68 centers in 22 European countries. All patients admitted to the waitlist for lung transplantation with a diagnosis of “ARDS//pneumonia” were included. Patients without extracorporeal membrane oxygenation (ECMO) or mechanical ventilation were excluded. Patients were followed until October 1st 2020 or death. Multivariable analysis for 1-year survival after listing and lung transplantation were performed.ResultsForty-eight centers (74%) with a total transplant activity of 12 438 lung transplants during the 9-year period gave feedback. Forty patients with a median age of 35 years were identified. Patients were listed for LTX in 18 different centers in 10 countries. Thirty-one-patients underwent LTX (0·25% of all indications) and 9 patients died on the waitlist. Ninety percent of transplanted patients were on ECMO in combination with mechanical ventilation before LTX. On multivariable analysis, transplantation during 2015 until 2019 was independently associated with better 1-year survival after LTX (odds ratio 10.493, 95% CI 1.977, 55.705, p=0.006). Sixteen survivors out of 23 patients with known status (70%) returned to work after LTX.ConclusionLTX in highly selected ARDS patients is feasible and outcome has improved in the modern era. The selection process remains ethically and technically challenging.

scholarly journals Age dependence of serum β-N-acetylhexosaminidase (NAG) activity

2004 ◽  
Vol 42 (3) ◽  
Author(s):  
Anna V. Oláh ◽  
Robert G. Price ◽  
László Csáthy ◽  
Éva Országh ◽  
Éva Oláh ◽  
...  
Keyword(s):  
Early Childhood ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Necrotizing Enterocolitis ◽  
Vascular Injury ◽  
Distress Syndrome ◽  
Reference Ranges ◽  
Age Dependence ◽  
Infant Respiratory Distress Syndrome ◽  
Age Dependent

AbstractSerum N-acetyl-β-D-glucosaminidase (NAG; EC 3.2.1.30) is a hexosaminidase and may be a predictor of vascular injury, e.g., in infant respiratory distress syndrome, pneumonia, broncho-pulmonary dysplasia and necrotizing enterocolitis. To estimate the new diagnostic prospects we have modified our urinary NAG assay. In this sensitive colorimetric micro-assay, VRA-GlcNAc was used as a substrate. In the present study the age dependence of serum NAG activity was investigated in newborn babies, infants (1–24 months), children (2–18 years) and adults (19–80 years). Serum NAG activity was found to be age-dependent; it is higher in early childhood (11–59 U/l) but decreases to a constant value at the age of 1–2 years. After the age of 2 years it is similar to adults' NAG (10–30 U/l). In pediatrics age-matched reference ranges must be taken into consideration.

scholarly journals Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient

2020 ◽  
Vol 8 (10) ◽  
pp. 1057-1060 ◽  
Author(s):  
Christian Lang ◽  
Peter Jaksch ◽  
Mir Alireza Hoda ◽  
György Lang ◽  
Thomas Staudinger ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Lung Transplantation ◽  
Distress Syndrome ◽  
Positive Patient

Outcome of unexplained acute respiratory distress syndrome with diffuse alveolar damage after lung transplantation

2018 ◽  
Vol 44 (4) ◽  
pp. 525-527
Author(s):  
François Stéphan ◽  
Vincent Thomas de Montpréville ◽  
Coumba Diarra ◽  
Catherine Pilorge ◽  
Elie Fadel ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Lung Transplantation ◽  
Distress Syndrome ◽  
Diffuse Alveolar Damage

Double Lung Transplantation for Adult Respiratory Distress Syndrome After Recombinant Interleukin 2

CHEST Journal ◽  
1993 ◽  
Vol 104 (2) ◽  
pp. 609-610 ◽  
Author(s):  
Pierre Y. Brichon ◽  
Didier Barnoud ◽  
Christophe Pison ◽  
Ignacio Perez ◽  
Michel Guignier
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Lung Transplantation ◽  
Adult Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Interleukin 2 ◽  
Recombinant Interleukin 2
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