A new perspective to lipid nanoparticles for oral drug delivery

Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients. These have been exploited for many features in the field of pharmaceutical technology. Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size and increasing their GIT residence time. In addition, lipid nanoparticles may also protect the loaded drugs from chemical and enzymatic degradation and gradually release drug molecules from the lipid matrix into blood, resulting in improved therapeutic profiles compared to free drug. Therefore, due to their physiological and biodegradable properties, lipid molecules may decrease adverse side effects and chronic toxicity of the drug-delivery systems when compared to other of polymeric nature. This paper highlights the importance of lipid nanoparticles to modify the release profile and the pharmacokinetic parameters of drugs when administrated through oral route.

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A concise review on preparation methods used for the development of solid lipid nanoparticles

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v11i1-s.4687 ◽

2021 ◽

Vol 11 (1-s) ◽

pp. 162-169

Author(s):

Vasu Deva Reddy Matta

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Solid Lipid Nanoparticles ◽

Oral Drug Delivery ◽

Lipid Nanoparticles ◽

Water Soluble ◽

Oral Drug ◽

Preparation Methods ◽

Hydrophilic Drugs ◽

Solid Lipid

Solid lipid nanoparticles (SLNs) are in submicron size range nanoparticles and are made of biocompatible and biodegradable materials (mainly composed of lipids and surfactants) capable of incorporating both lipophilic and hydrophilic drugs. SLNs are also considered as substitute to other colloidal drug systems, also used as controlled systems and targeted delivery. SLNs can be considered as an alternative for oral drug delivery vehicle to improve the oral bioavailability of drugs, associated reduction of drug toxicity and stability of drug in both GIT and plasma. There are different techniques used for the preparation of SLNs. Generally, the preparation of SLNs and any other nanoparticle system necessitates a dispersed system as precursor; otherwise particles are produced through the use of a particular instrumentation. This review provides the summary on the techniques or methods used for the development of SLNs of poorly water soluble drugs for improved drug delivery. Keywords: Solid lipid nanoparticles, controlled delivery, precursor, techniques.

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Solid Lipid Nanoparticles for Oral Drug Delivery: A Review

Current Nanomedicine ◽

10.2174/2468187310666200221105315 ◽

2020 ◽

Vol 10 (3) ◽

pp. 208-224

Author(s):

Manish Gautam ◽

Madhu Verma ◽

Iti Chauhan ◽

Mohd. Yasir ◽

Alok Pratap Singh ◽

...

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Oral Drug Delivery ◽

Lipid Nanoparticles ◽

Delivery Systems ◽

Water Soluble ◽

Oral Drug ◽

Pharmacokinetic Studies ◽

Future Prospects ◽

Solid Lipid

Background: The high molecular weight and increasing lipophilicity of drug face many problems starting from the drug development to formulation and conduction of pharmacological, toxicological and pharmacokinetic studies to its biological application. To overcome this problem, nano-sized formulations are in trend recently. The use of Solid lipid nanoparticles (SLNs) offers new insight into the formulation of the poor soluble and low bioavailable drug. Objective: The study aimed to investigate the literature concerning the development of SLNs for oral drug delivery of poorly soluble drugs, with a view survey the various methods of manufacturing and evaluation of formulation of SLNs and future prospects of SLNs and application of SLNs in oral delivery systems. Conclusion: Oral drug delivery is looking ahead progressively into newer directions due to the realization of various poor performance limiting factors such as reduced drug solubility or absorption, rapid metabolism, high actuation in plasma level of drug and variability caused due to food effect. These play a vital role in disappointing in vivo results, which leads in the failure of the conventional delivery system. Since the last decade, oral drug delivery has taken a new dimension with the increasing application of SLNs as a carrier for the delivery of poorly water-soluble or lipophilic drugs. The site-specific and sustained release effect of the drug is better achieved by using SLNs. This review highlights the various pros and cons, manufacturing techniques, characterization, and future prospects of SLNs in oral drug delivery systems.

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