scholarly journals The Importance of Choosing the Optimal Solid Form of a Drug

2012 ◽  
pp. 349-383 ◽  
Author(s):  
Rolf Hilfiker
Keyword(s):  
Solid Form

Choice of diagnosis of solid form of papillary carcinoma in pathological investigation rather than fine needle aspiration

2020 ◽  
Author(s):  
Lali Tigishvili ◽  
Keti Tsomaia ◽  
Khatuna Khachapuridze ◽  
Nino Kekelidze ◽  
Giorgi Mchedlishvili ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Solid Form

IDENTIFIKASI KARAKTERISTIK MEKANIS BANTALAN LUNCUR MOTOR STARTER DARI SERBUK TEMBAGA ALUMUNIUM

2013 ◽  
Vol 12 (3) ◽  
Author(s):  
Syamsul Rizal ◽  
Amin Suhandi
Keyword(s):  
Mechanical Test ◽  
Life Time ◽  
Extrusion Process ◽  
Automotive Application ◽  
Powder Metallurgy Method ◽  
Powder Metal ◽  
Time Operation ◽  
Different Temperatures ◽  
Automotive Parts ◽  
Solid Form

There are many attempts to support the development of industry in Indonesia, especially on automotive sector, one of them is by replacing import components with local component products. Bushing is one of imported component that widely used on automotive application including motor strater. Bushing usually made of  copper alloy such as brass, bronz or babbit in a solid form by casting or extrusion process. In this research powder metal technology is used to process Cu-Al powder to become slide bearing of motor starter. It is expected that powder metal process not only increasing local content in automotive parts but also providing better quality by increasing life time of bushing compared to ordinary one. Cu-Al metal powder was compacted at various pressure, i.e: 250 MPa, 350 MPa and 450 MPa, and then all specimens were sintered at different temperatures : 4000C, 5000C dan 6000C for 1 hour.  After sintering specimens were air cooled to room temperature. After physical and mechanical test it can be deduced that bushing made by powder metallurgy method could increase its mechanical properties and as aresult improve its life time operation.  

The Effect of Dry Mix Sodium Hydroxide onto Workability and Compressive Strength of Geopolymer Paste

2020 ◽  
Vol 12 (9) ◽  
Author(s):  
A. Z. Mohd Ali ◽  
◽  
N. A. Jalaluddin ◽  
N. Zulkiflee ◽  
◽  
...  
Keyword(s):  
Compressive Strength ◽  
Fly Ash ◽  
Sodium Hydroxide ◽  
Sodium Silicate ◽  
Alkaline Solution ◽  
High Emission ◽  
New Material ◽  
Curing Regime ◽  
Solid Form ◽  
Geopolymer Paste

The production of ordinary Portland cement (OPC) consumes considerable amount of natural resources, energy and at the same time contribute in high emission of CO2 to the atmosphere. A new material replacing cement as binder called geopolymer is alkali-activated concrete which are made from fly ash, sodium silicate and sodium hydroxide (NaOH). The alkaline solution mixed with fly ash producing alternative binder to OPC binder in concrete named geopolymer paste. In the process, NaOH was fully dissolved in water and cooled to room temperature. This study aims to eliminate this process by using NaOH in solid form together with fly ash before sodium silicate liquid and water poured into the mixture. The amount of NaOH solids were based on 10M concentration. The workability test is in accordance to ASTM C230. Fifty cubic mm of the geopolymer paste were prepared which consists of fly ash to alkaline solution ratio of 1: 0.5 and the curing regime of 80℃ for 24 hours with 100% humidity were implemented. From laboratory test, the workability of dry method geopolymer paste were decreased. The compressive strength of the dry mix of NaOH showed 55% and the workability has dropped to 58.4%, it showed strength reduction compared to the wet mix method.

Reactions

2011 ◽  
Author(s):  
Peter Atkins
Keyword(s):  
Chemical Reactions ◽  
Molecular Level ◽  
Chemical Processes ◽  
Chemical Formula ◽  
Complex Processes ◽  
Full Color ◽  
Chemistry Textbooks ◽  
Simple Chemical ◽  
The Subject ◽  
Solid Form

Illustrated with remarkable new full-color images--indeed, one or more on every page--and written by one of the world's leading authorities on the subject, Reactions offers a compact, pain-free tour of the inner workings of chemistry. Reactions begins with the chemical formula almost everyone knows--the formula for water, H2O--a molecule with an "almost laughably simple chemical composition." But Atkins shows that water is also rather miraculous--it is the only substance whose solid form is less dense than its liquid (hence ice floats in water)--and incredibly central to many chemical reactions, as it is an excellent solvent, being able to dissolve gases and many solids. Moreover, Atkins tells us that water is actually chemically aggressive, and can react with and destroy the compounds dissolved in it, and he shows us what happens at the molecular level when water turns to ice--and when it melts. Moving beyond water, Atkins slowly builds up a toolkit of basic chemical processes, including precipitation (perhaps the simplest of all chemical reactions), combustion, reduction, corrosion, electrolysis, and catalysis. He then shows how these fundamental tools can be brought together in more complex processes such as photosynthesis, radical polymerization, vision, enzyme control, and synthesis. Peter Atkins is the world-renowned author of numerous best-selling chemistry textbooks for students. In this crystal-clear, attractively illustrated, and insightful volume, he provides a fantastic introductory tour--in just a few hundred colorful and lively pages - for anyone with a passing or serious interest in chemistry.

scholarly journals Radiological features of body packers: An experience from a regional accident and emergency department in close proximity to the Hong Kong International Airport

2018 ◽  
Vol 25 (4) ◽  
pp. 202-210
Author(s):  
Ho Kai Patrick Tsang ◽  
Cheuk Kei Kathy Wong ◽  
Oi Fung Wong ◽  
Wing Lun William Chan ◽  
Hing Man Ma ◽  
...  
Keyword(s):  
Emergency Department ◽  
Hong Kong ◽  
Body Packing ◽  
Radiological Features ◽  
International Airport ◽  
Accident And Emergency ◽  
Accident And Emergency Department ◽  
Body Packers ◽  
Solid Form ◽  
Hong Kong International Airport

Background: Body packing is a frequently used method for drug trafficking. Local information about the clinical and radiological features of body packing is lacking. Objectives: To evaluate the radiological features of body packers presenting to a hospital near to the Hong Kong International Airport and to compare the radiological features of solid form versus liquid cocaine. Methods: This was a retrospective cohort study. Medical notes of 269 suspected body packers, presenting to the Accident and Emergency Department of North Lantau Hospital under the detention by the law enforcement personnel from 1st January 2015 to 28th February 2017, were reviewed. The radiological features of body packing were retrospectively evaluated. Results: Sixty-nine cases were confirmed body packers radiographically. Majority of them (81%, 56/69) were cocaine packers. Powder form cocaine (67%, 49/69) was the most popular drug packed, followed by liquid cocaine (15%, 10/69). There was a trend of increasing incidence of liquid cocaine packers. The classical ‘double condom’, ‘tic tac’ and ‘halo’ signs were present in 94%, 72.5% and 42% of cases with radiologically confirmed body packing respectively. The ‘rosette’ sign was only identified in 1 case. Three new radiological signs, the ‘bag of eggs’, ‘lucent triangle’ and ‘black crescent’ sign, were suggested to aid identification of drug packets. The classical ‘tic tac’ sign was absent in all liquid cocaine packing cases (p<0.05). The liquid cocaine packets appeared irregular with indistinct border in majority of cases (p<0.05). The solid form packets were mostly opaque to faeces while liquid cocaine had variable density (p<0.05). Most solid form packets had homogeneous content which was in contrast to the heterogeneous content in liquid cocaine (p<0.05). Conclusion: Failure in detecting drug body packing may result in medicolegal consequences. Emergency physicians need to be aware of subtle radiological signs of liquid cocaine packets in the plain abdominal radiography.

On the Thermo-electric Properties of Solid and Liquid Mercury

1902 ◽  
Vol 23 ◽  
pp. 15-15 ◽  
Author(s):  
W. Peddie ◽  
A. B. Shand
Keyword(s):  
Carbonic Acid ◽  
Large Mass ◽  
Electric Properties ◽  
Considerable Time ◽  
Chemical Laboratory ◽  
Thermo Electric ◽  
Liquid Mercury ◽  
Usual Manner ◽  
Solid Form ◽  
The University

AbstractBy means of a large quantity of solid carbonic acid, obtained from the University Chemical Laboratory, it was found possible to solidify, and maintain in the solid form for a considerable time, a large mass of mercury. Preliminary experiments made about a year ago, in the usual manner, by means of a triple circuit (iron, german silver, mercury), did not give results of a satisfactory kind. This was apparently due to the difficulty of maintaining steady, or steadily varying, temperatures.

scholarly journals Acemetacin cocrystals and salts: structure solution from powder X-ray data and form selection of the piperazine salt

IUCrJ ◽  
2014 ◽  
Vol 1 (2) ◽  
pp. 136-150 ◽  
Author(s):  
Palash Sanphui ◽  
Geetha Bolla ◽  
Ashwini Nangia ◽  
Vladimir Chernyshev
Keyword(s):  
Hydrogen Bonds ◽  
Dissolution Rate ◽  
Aqueous Medium ◽  
Acid Amide ◽  
Three Dimensional ◽  
X Ray Diffraction ◽  
Reference Drug ◽  
X Ray ◽  
Time Period ◽  
Solid Form

Acemetacin (ACM) is a non-steroidal anti-inflammatory drug (NSAID), which causes reduced gastric damage compared with indomethacin. However, acemetacin has a tendency to form a less soluble hydrate in the aqueous medium. We noted difficulties in the preparation of cocrystals and salts of acemetacin by mechanochemical methods, because this drug tends to form a hydrate during any kind of solution-based processing. With the objective to discover a solid form of acemetacin that is stable in the aqueous medium, binary adducts were prepared by the melt method to avoid hydration. The coformers/salt formers reported are pyridine carboxamides [nicotinamide (NAM), isonicotinamide (INA), and picolinamide (PAM)], caprolactam (CPR),p-aminobenzoic acid (PABA), and piperazine (PPZ). The structures of an ACM–INA cocrystal and a binary adduct ACM–PABA were solved using single-crystal X-ray diffraction. Other ACM cocrystals, ACM–PAM and ACM–CPR, and the piperazine salt ACM–PPZ were solved from high-resolution powder X-ray diffraction data. The ACM–INA cocrystal is sustained by the acid...pyridine heterosynthon and N—H...O catemer hydrogen bonds involving the amide group. The acid...amide heterosynthon is present in the ACM–PAM cocrystal, while ACM–CPR contains carboxamide dimers of caprolactam along with acid–carbonyl (ACM) hydrogen bonds. The cocrystals ACM–INA, ACM–PAM and ACM–CPR are three-dimensional isostructural. The carboxyl...carboxyl synthon in ACM–PABA posed difficulty in assigning the position of the H atom, which may indicate proton disorder. In terms of stability, the salts were found to be relatively stable in pH 7 buffer medium over 24 h, but the cocrystals dissociated to give ACM hydrate during the same time period. The ACM–PPZ salt and ACM–nicotinamide cocrystal dissolve five times faster than the stable hydrate form, whereas the ACM–PABA adduct has 2.5 times faster dissolution rate. The pharmaceutically acceptable piperazine salt of acemetacin exhibits superior stability, faster dissolution rate and is able to overcome the hydration tendency of the reference drug.

scholarly journals Novel solid forms of the analgesic drug ethenzamide

2014 ◽  
Vol 70 (a1) ◽  
pp. C995-C995
Author(s):  
Duane Choquesillo-Lazarte ◽  
Cristóbal Verdugo-Escamilla ◽  
Juan Manuel García-Ruiz
Keyword(s):  
Polycrystalline Material ◽  
X Ray Diffraction ◽  
Analgesic Drug ◽  
X Ray ◽  
Solution Methods ◽  
Additional Stability ◽  
Ft Ir ◽  
Model Drug ◽  
Solid Form ◽  
Ir And Raman

The interest in multicomponent solid forms has increased in the last years within the pharmaceutical industry and also the solid-state community due to the possibility of obtaining materials with new properties [1]. Crystallization strategies, supported by solvent- and solid-based techniques, have also received attention in the search and development of methodologies for the screening of multicomponent crystals. In this work, ethenzamide, an anti-inflammatory and analgesic drug, was selected as a model drug to develop cocrystals on the basis of the synthon types using a series of phenolic coformers. Ethenzamide cocrystals and cocrystal solvates have been reported recently [2,3]. Liquid Assisted Grinding (LAG) and solution methods were used as synthetic tools. Attempts to produce cocrystals by LAG and Reaction Crystallization led to the formation of polycrystalline material. The solids obtained were then characterized by powder X-ray diffraction (PXRD), FT-IR and Raman spectroscopy. Recrystallization by slow solvent evaporation was carried out when the above-referred techniques strongly suggest the formation of a new solid form. The structure of five new multicomponent solids has been determined by single crystal X-ray diffraction. Additional stability studies have been performed at controlled relative humidity conditions and followed by PXRD.

Sign in / Sign up

Export Citation Format

Share Document